권호기사보기
| 기사명 | 저자명 | 페이지 | 원문 | 기사목차 |
|---|
결과 내 검색
동의어 포함
Contents
Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis / Yijie Li ; Jing Liu ; Yimin Zhu ; Chunying Peng ; Yao Dong ; Lili Liu ; Yining He ; Guoping Lu ; Yingjie Zheng 1
[요약] 1
Introduction 1
Materials and Methods 2
Results 3
Discussion 7
References 8
The role of oral microbiota in viral encephalitis and/or viral meningitis (VEVM) remains unclear. In this hospital-based, frequency-matched study, children with clinically diagnosed VEVM (n = 68) and those with other diseases (controls, n = 68) were recruited. Their oral swab samples were collected and the oral microbiota was profiled using 16S rRNA gene sequencing. The oral microbiota of children with VEVM exhibited different beta diversity metrics (unweighted UniFrac distance: P < 0.001, R2 = 0.025, Bray-curtis dissimilarity: P = 0.045, R2 = 0.011, and Jaccard dissimilarity: P < 0.001, R2 = 0.017) and higher relative abundances of taxa identified by Linear discriminant analysis (LDA) with effect size (Enterococcus, Pedobacter, Massilia, Prevotella_9, Psychrobacter, Butyricimonas, Bradyrhizobium, etc., LDA scores > 2.0) when compared with the control group. The higher pathway abundance of steroid hormone biosynthesis predicted by oral microbiota was suggested to be linked to VEVM (q = 0.020).
Further, a model based on oral microbial traits showed good predictive performance for VEVM with an area under the receiver operating characteristic curve of 0.920 (95% confidence interval: 0.834–1.000). Similar results were also obtained between children with etiologically diagnosed VEVM (n = 43) and controls (n = 68). Our preliminary study identified VEVM-specific oral microbial traits among children, which can be effective in the diagnosis of VEVM.*표시는 필수 입력사항입니다.
| 전화번호 |
|---|
| 기사명 | 저자명 | 페이지 | 원문 | 기사목차 |
|---|
| 번호 | 발행일자 | 권호명 | 제본정보 | 자료실 | 원문 | 신청 페이지 |
|---|
도서위치안내: 정기간행물실(524호) / 서가번호: 국내17
2021년 이전 정기간행물은 온라인 신청(원문 구축 자료는 원문 이용)
우편복사 목록담기를 완료하였습니다.
*표시는 필수 입력사항입니다.
저장 되었습니다.