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The maintenance of glucose homeostasis is fundamental for survival and health. Diabetes develops when glucose homeostasis fails. Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell failure. The failure of β-cells to compensate for insulin resistance results in hyperglycemia, which in turn drives altered lipid metabolism and β-cell failure. Thus, insulin secretion by pancreatic β-cells is a primary component of glucose homeostasis. Impaired β-cell function and reduced β-cell mass are found in diabetes. Both features stem from a failure to maintain β-cell identity, which causes β-cells to dedifferentiate into nonfunctional endocrine progenitor-like cells or to trans-differentiate into other endocrine cell types. In this regard, one of the key issues in achieving disease modification is how to reestablish β-cell identity. In this review, we focus on the causes and implications of β-cell failure, as well as its potential reversibility as a T2D treatment.

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기사명 저자명 페이지 원문 목차
AIVariant : a deep learning-based somatic variant detector for highly contaminated tumor samples Hyeonseong Jeon, Junhak Ahn, Byunggook Na, Soona Hong, Lee Sael, Sun Kim, Sungroh Yoon, Daehyun Baek p. 1-9

Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder Gaeun Park, Wooyoung Eric Jang, Seoyeon Kim, Edson Luck Gonzales, Jungeun Ji, Seunghwan Choi, Yujin Kim, Ji Hwan Park, Hazara Begum Mohammad, Geul Bang ... [et al.] p. 1-12

SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways Xiaojuan Ren, Chao Feng, Yubo Wang, Pu Chen, Simeng Wang, Jianling Wang, Hongxin Cao, Yujun Li, Meiju Ji, Peng Hou p. 1-13

Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes Jinsook Son, Domenico Accili p. 1-7

Phosphoinositides and intracellular calcium signaling : novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling Byung-Chul Oh p. 1-11

Olfactory modulation of stress-response neural circuits Min-Gi Shin, Yiseul Bae, Ramsha Afzal, Kunio Kondoh, Eun Jeong Lee p. 1-13

Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair Eunhwan Kim, Seol Hwa Seo, Yumi Hwang, Yeong Chan Ryu, Heejene Kim, Kyoung-Mi Lee, Jin Woo Lee, Kwang Hwan Park, Kang-Yell Choi p. 1-13

Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy Hyun-Jun Jang, Yo Han Lee, Tam Dao, Yunju Jo, Keon Woo Khim, Hye-jin Eom, Ju Eun Lee, Yi Jin Song, Sun Sil Choi, Kieun Park ... [et al.] p. 1-14

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su ... [et al.] p. 1-14

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion : patient-derived keloid xenograft (PDKX) model A Ram Lee, Seon-Yeong Lee, Jeong Won Choi, In Gyu Um, Hyun Sik Na, Jung Ho Lee, Mi-La Cho p. 1-7

Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Kim p. 1-14

Microbiota influences host exercise capacity via modulation of skeletal muscle glucose metabolism in mice Hye Jin Kim, Youn Ju Kim, Yong Jae Kim, Ji Hyeon Baek, Hak Su Kim, Il Yong Kim, Je Kyung Seong p. 1-11

(A) single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lung Woochan Lee, Seyoon Lee, Jung-Ki Yoon, Dakyung Lee, Yuri Kim, Yeon Bi Han, Rokhyun Kim, Sungji Moon, Young Jun Park, Kyunghyuk Park ... [et al.] p. 1831-1842

(An) integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis Jong Woo Kim, Ji-Yoon Lee, Mihee Oh, Eun-Woo Lee p. 1620-1631

Mitochondria-associated programmed cell death as a therapeutic target for age-related disease Thanh T. Nguyen, Shibo Wei, Thu Ha Nguyen, Yunju Jo, Yan Zhang, Wonyoung Park, Karim Gariani, Chang-Myung Oh, Hyeon Ho Kim, Ki-Tae Ha ... [et al.] p. 1595-1619

Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis Ein Lee, Chang-Hyun Song, Sung-Jin Bae, Ki-Tae Ha, Rajendra Karki p. 1632-1643

Diversity and complexity of cell death : a historical review Wonyoung Park, Shibo Wei, Bo-Sung Kim, Bosung Kim, Sung-Jin Bae, Young Chan Chae, Dongryeol Ryu, Ki-Tae Ha p. 1573-1594

After cell death : the molecular machinery of efferocytosis Byeongjin Moon, Susumin Yang, Hyunji Moon, Juyeon Lee, Daeho Park p. 1644-1651

참고문헌 (102건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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51 Hong, H. J. et al. Mitoribosome insufficiency in beta cells is associated with type 2 diabetes-like islet failure. Exp. Mol. Med. 54, 932–945 (2022). 미소장
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55 Jonas, J. C. et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J. Biol. Chem. 274, 14112–14121 (1999). 미소장
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63 Tong, X. et al. Lipid droplet accumulation in human pancreatic islets is dependent on both donor age and health. Diabetes 69, 342–354 (2020). 미소장
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65 Gutierrez, G. D. et al. Pancreatic beta cell identity requires continual repression of non-beta cell programs. J. Clin. Invest. 127, 244–259 (2017). 미소장
66 Gao, T. et al. Pdx1 maintains beta cell identity and function by repressing an alpha cell program. Cell Metab. 19, 259–271 (2014). 미소장
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77 Xin, Y. et al. RNA sequencing of single human islet cells reveals type 2 diabetes genes. Cell Metab. https://doi.org/10.1016/j.cmet.2016.08.018 (2016). 미소장
78 Baron, M. et al. A single-cell transcriptomic map of the human and mouse pancreas reveals inter- and intra-cell population structure. Cell Syst. 3, 346–360 e344 (2016). 미소장
79 Xin, Y. et al. Pseudotime ordering of single human beta-cells reveals states of insulin production and unfolded protein response. Diabetes 67, 1783–1794 (2018). 미소장
80 Wang, Y. J. et al. Single-cell transcriptomics of the human endocrine pancreas. Diabetes 65, 3028–3038 (2016). 미소장
81 Avrahami, D. et al. Single-cell transcriptomics of human islet ontogeny defines the molecular basis of beta-cell dedifferentiation in T2D. Mol. Metab. 42, 101057 (2020). 미소장
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