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Tissue engineering approaches aim to overcome the limitations of organ transplants and facilitate tissue repair and regeneration, with demand now at a worldwide high for advanced therapies due to our global aging population. Neural tissue engineering is challenging with tissue dynamics and cellular complexity constraints necessary for tissue function. Here, a conductive, highly aligned, fibrous polycaprolactone/gelatin/polypyrrole/graphene scaffold is demonstrated for potential nerve tissue repair. A simple and efficient electrospinning technique with a rotating drum fabrication approach is utilized to create aligned fibrous structures with a diameter of 380 ± 37 nm (no graphene) to 265 ± 30 nm (up to 3 wt% graphene). The conductivity of the scaffold in wet conditions was found range from 0.76 ± 0.1 S m-1 with no graphene, to 3.96 ± 0.2 S m-1 with 3% wt graphene, with corresponding ultimate tensile strengths measuring 2.6 ± 0.1-5.5 ± 0.4 MPa, respectively. Samples were found to biodegrade during incubation in saline solution over 42 days by ~ 48.5%. Fibroblasts were used as a cell model to test for scaffold toxicity, with all samples presenting good cell adhesion and limited cytotoxicity. Overall, the results demonstrated an aligned fibrous platform with good mechanical and electrically conductive properties useful for tissue engineering applications, particularly for nerve tissue. Development of novel materials with a range of properties enabling optimization of cell adhesion through to tissue development will further support the development of regenerative medicine approaches.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Polycaprolactone/gelatin/polypyrrole/graphene conductive aligned fibrous scaffold with ferulic acid encapsulation for tissue engineering applications Alireza Talebi, Pegah Madani Nasab, Sheyda Labbaf, Paul Roach p. 2995-3006
Effects of KBrO3 on chemical, aggregation and morphological structure of polyacrylonitrile (PAN) precursor fibers Yatian Chen, Bin He, Qiufei Chen, Hamza Malik, Hongqiang Zhu, Yuhang Wang, Jian He, Bomou Ma, Xueli Wang, Hui Zhang, Yong Liu p. 3007-3017
Facile, dip coating fabrication of polymeric electropositive membrane filter exploiting electrostatic interactions Dalsu Choi, Yeojin Ahn, KyungYoul Baek, SoHye Cho, Han Bi Lee, Min Wook Lee, Seong Mu Jo p. 3019-3026
Preparation and characterization of sisal cellulose nanocrystals‑assembled film Yaqian Peng, Yu Zhang, Zunyan Li, Helan Xu, Xiuliang Hou p. 3027-3036
Mechanical properties, morphological characteristics and microstructural changes of poly(glycolide‑co‑ε‑caprolactone‑co‑L‑lactide) suture during in vitro degradation Min Ho Jee, Song Yeon Choi, Chan Sol Kang, Doo Hyun Baik p. 3037-3045
(An) adsorptive membrane based on electrospun graphene oxide/poly(vinylidene) fluoride fiber coated with chitosan for removal of manganese ions from aqueous solutions using a simple filtration process Le Thi Le, Phan Ngoc Vu, Huu The Nguyen, Manh Van Nguyen, Hieu Trung Bui, Huy Quang Tran, Thuy Thi Thu Nguyen p. 3047-3060
Flexibility and thermal storage properties of polyurethane adhesive supported phase change composites based on polyurethane phase change materials Jiankun Dong, Wenzhao Shi, Jinshu Liu, Shaofeng Lu, Hongjuan Zhou, Shanshan Cui, Manyan Zhang, Guoxin Su p. 3061-3074
Batch preparation and characterization of anthocyanin/CS/PEO nanofiber membranes for food packages Adnan Ahmed, Meng Zhang, Siqi Li, Lan Xu p. 3075-3084
Microstructure, mechanical, and in vitro performance of a novel combination of layered double hydroxides and polycaprolactone electrospun/3D printed scaffolds for bone tissue engineering Ghazal Belgheisi, Masoumeh Haghbin Nazarpak, Mehran SolatiHashjin p. 3085-3099
Crystallization and mechanical properties of the polylactide melt blown nonwovens Lin Meng, Fangdong Zou, Mingjing Chen, Yifei Li, Yingying Wang, Xiaoxia Sun, Xinhou Wang p. 3101-3114
Anti-infective knitted surgical mesh for stress urinary incontinence applications : synthesis, characterization, and investigation of its in vitro biocompatibility Ogün Bozkaya p. 3115-3127
Fabrication and characterization of polypropylene/aluminum fibers for wearable applications in the infrared region Elham Tavakkol, Sedigheh Borhani, Abolghasem Zeidaabadi Nezhad, Mohsen Shanbeh, Mohammad Ali Alsharif p. 3129-3137
Ultrathin polymer fibers coated with an amorphous SiO2–CaO–P2O5 bioactive powders for biomedical applications Lilian de Siqueira, Verônica Ribeiro dos Santos, Juliani Caroline Ribeiro de Araújo, Hugo Gutemberg Patiño de Oliveira Filho, Luana Marotta Reis de Vasconcellos, Eliandra de Sousa Trichês, Alexandre Luiz Souto Borges p. 3139-3150
Polycrystalline nanograin formation in uniform‑sized silicon carbide fibers derived from aluminum‑containing polycarbosilane Yeeun Song, Young Jun Joo, Yangyul Ju, Byungwook Youn, Dong Geun Shin, Kwang Youn Cho, Doojin Lee p. 3151-3161
Multi‑objective optimisation of antibacterial activity and comfort of knitted fabrics made from polyester‑silver nanocomposite fibres Prakash Khude, Abhijit Majumdar, Bhupendra Singh Butola, Rajib Bhattacharyya p. 3163-3173
Application of Achillea millefolium as a natural antibacterial agent in finishing of textile Fazlıhan Yılmaz p. 3175-3182
Aqueous sol–gel nano‑coating of titanium dioxide on cotton and silk fabrics for self‑cleaning and UV protection finish Subhankar Maity, Sandeep Tiwari, Prashant Vishnoi p. 3183-3193
Use of Bixa orellana and Curcuma longa L. as a natural protection factor for cotton fabrics Arielma Marques dos Santos, Itamara Farias Leite p. 3195-3209
Removal of reactive blue 49 (RB) onto untreated peanut shell (UPS) waste : kinetic study, modeling, mechanism, and regeneration of the adsorbent Moussa Abbas, Mohamed Trari p. 3211-3220
Color shade extension of Reseda luteola L. natural colorant on wool textiles via binary combination of metal salts : colorimetric and fastness studies Siyamak Safapour, Majid Mazhar, Saiedeh Abedinpour p. 3221-3233
Radar absorbing capability and fatigue properties of unidirectional carbon fabric-reinforced composites Gulsah Pamuk, Ugur Kemiklioglu p. 3235-3244
Analysis of honeycomb and sandwich structure compression property and the damage of double cell wall Lihong Xu, Can Ni, Gang Liu, Junli Li p. 3245-3260
Influence of active SMA fibre on deflection recovery characteristics of damaged laminated composite theoretical and experimental analysis Erukala Kalyan Kumar, Subrata Kumar Panda, S.R. Mahmoud, Mohammed Balubaid p. 3261-3277
Bioinspired hard–soft interface management for superior performance in carbon fibre composites Ben Newman, James D. Randall, Russell J. Varley, Filip Stojcevski, Luke C. Henderson p. 3279-3288
Numerical and experimental investigations on the low velocity impact properties of glass fiber reinforced epoxy composites : effects of radius of curvature Erfan Avazpoor, Amir Hossein Kazemian, Hossein Rahmani p. 3289-3298
Effect of thread count on the shear mechanical properties and dynamic mechanical properties of shape memory polymer reinforced by single-ply weave fabric Peng Qu, Guangqiang Fang, He Kong, Zhengli Cao, Jia Ma, Zhiyi Wang, Anfu Guo, Shaoqing Wang, Xunjin Li, Xinran Shan p. 3299-3317
(A) new cell modeling method to calculate the mechanical properties of 3D braided composites Vivek Kumar Dhimole, Da Ea Lee, Chongdu Cho p. 3319-3332
Finite element analysis and performance comparison of leaf spring based on unidirectional sisal fiber‑reinforced epoxy composite against woven fiber‑reinforced composite Mohammed Irfan Khan, Chitresh Nayak p. 3333-3343
Synthesis and characterization of compound coupling agent-modified hollow glass microspheres/epoxy composites Zhaolin Zhu, Yin Liu, Guiyang Xian, Yan Wang, Chongmei Wu, Xiaobo Peng, Lingbing Kong p. 3345-3353
(A) green dual function engineering material : sound absorption and heat insulation based on water hyacinth fiber and waste palm oil Jiratti Tengsuthiwat, Sittichai Limrungruengrat, Nathapong Sukhawipat p. 3355-3368

참고문헌 (46건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Nanofiber Yarn/Hydrogel Core–Shell Scaffolds Mimicking Native Skeletal Muscle Tissue for Guiding 3D Myoblast Alignment, Elongation, and Differentiation 미소장
2 Graphene-based nanomaterials for drug delivery and tissue engineering 미소장
3 Development and characterization of novel electrically conductive PANI–PGS composites for cardiac tissue engineering applications 미소장
4 Patterning of Polymeric Materials for Biological Applications 미소장
5 Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering 미소장
6 Investigation of cell–surface interactions using chemical gradients formed from plasma polymers 미소장
7 A bio-inspired neural environment to control neurons comprising radial glia, substrate chemistry and topography 미소장
8 Biomimetic electrospun nanofibrous structures for tissue engineering 미소장
9 Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues 미소장
10 Effects of unidirectional permeability in asymmetric poly(DL‐lactic acid‐co‐glycolic acid) conduits on peripheral nerve regeneration: An in vitro and in vivo study 미소장
11 A potent inhibition of oxidative stress induced gene expression in neural cells by sustained ferulic acid release from chitosan based hydrogel 미소장
12 Optimization of fully aligned bioactive electrospun fibers for “in vitro” nerve guidance 미소장
13 Flat polymer ribbons and other shapes by electrospinning 미소장
14 In vitroevaluation of random and aligned polycaprolactone/gelatin fibers via electrospinning for bone tissue engineering 미소장
15 Manifestation of intermolecular interactions in FTIR spectra of methylene blue molecules 미소장
16 Nanotechnology and 3D Bioprinting for Neural Tissue Regeneration 미소장
17 Electrospinning and mechanical properties of polymeric fibers using a novel gap-spinning collector 미소장
18 Myosin phosphorylation on stress fibers predicts contact guidance behavior across diverse breast cancer cells 미소장
19 Cell-free artificial implants of electrospun fibres in a three-dimensional gelatin matrix support sciatic nerve regeneration in vivo 미소장
20 Influence of random and oriented electrospun fibrous poly(lactic‐co‐glycolic acid) scaffolds on neural differentiation of mouse embryonic stem cells 미소장
21 Graphene and functionalized graphene: Extraordinary prospects for nanobiocomposite materials 미소장
22 Design considerations when engineering neural tissue from stem cells 미소장
23 Conductive 3D structure nanofibrous scaffolds for spinal cord regeneration 미소장
24 Conducting Polymers for Tissue Engineering 미소장
25 Fabrication of Biocompatible PLGA/PCL/PANI Nanofibrous Scaffolds with Electrical Excitability 미소장
26 Soft Conducting Polymer Hydrogels Cross-Linked and Doped by Tannic Acid for Spinal Cord Injury Repair 미소장
27 Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo 미소장
28 Current and novel polymeric biomaterials for neural tissue engineering 미소장
29 A conductive film of chitosan-polycaprolcatone-polypyrrole with potential in heart patch application 미소장
30 Polyurethane/Gelatin Nanofiber Neural Guidance Conduit in Combination with Resveratrol and Schwann Cells for Sciatic Nerve Regeneration in the Rat Model 미소장
31 Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering 미소장
32 The advances in nerve tissue engineering: From fabrication of nerve conduit toin vivonerve regeneration assays 미소장
33 3D-Printed PCL/PPy Conductive Scaffolds as Three-Dimensional Porous Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair 미소장
34 Current progress in application of polymeric nanofibers to tissue engineering 미소장
35 Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve 미소장
36 Electroconductive Graphene-Containing Polymeric Patch: A Promising Platform for Future Cardiac Repair 미소장
37 Polypyrrole-Incorporated Conducting Constructs for Tissue Engineering Applications: A Review 미소장
38 Application of conductive PPy/SF composite scaffold and electrical stimulation for neural tissue engineering 미소장
39 Electrospun bioactive composites for neural tissue engineering applications 미소장
40 Conductive Composite Fiber with Optimized Alignment Guides Neural Regeneration under Electrical Stimulation 미소장
41 Natural and synthetic polymeric scaffolds used in peripheral nerve tissue engineering: Advantages and disadvantages 미소장
42 Simulation of precipitates evolution driven by non-isothermal cyclic thermal history during wire and arc additive manufacturing of IN718 superalloy 미소장
43 Design Challenges in Polymeric Scaffolds for Tissue Engineering 미소장
44 Biomaterials for Neural Tissue Engineering 미소장
45 Nanobioglass enhanced polyurethane/collagen conduit in sciatic nerve regeneration 미소장
46 Conductive hydrogels for tissue repair 미소장

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