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B16F10.OVA cell에서 Atorvastatin에 의한 Ferroptosis 유도 규명 ＝ Identification of ferroptosis induction by treating atorvastatin in B16F10.OVA cells / 김민석 ; 임인호 ; 정윤화 ; 김승현 ; 조영창 ; 최정욱 1

Abstract 1

서론(Introduction) 1

방법(Methods) 2

결과(Results) 3

고찰(Discussion) 6

결론(Conclusion) 6

References 7

초록보기

In this study, we identified whether atorvastatin could induce ferroptosis or not in B16F10.OVA cells, whichis being used to treat hypercholesterolemia. To demonstrate this, we treated the mouse melanoma cell line B16F10.OVAwith atorvastatin at varying concentrations, spanning from low to high, followed by a 24-hour culture period. In the grouptreated with atorvastatin in our experiment, we observed a decrease in cell viability that was dependent on theconcentration of the treatment, when compared to the control group. The IC50 value of atorvastatin in B16F10.OVA cellswas determined to be 49.89 μM. Compared to the control group, treatment with atorvastatin resulted in a concentrationdependentincrease in the generation of reactive oxygen species and the accumulation of iron ions. Moreover, atorvastatintreatment exhibited a concentration-dependent increase in the population of apoptotic cells and the expression ofcalreticulin, significantly surpassing that of the control group. The analysis of ferroptosis-related protein expression levelsrevealed a notable decrease in the expression of GPX4 in the group treated with atorvastatin, as compared to the controlgroup. These findings strongly suggest that atorvastatin holds promise as a potent anti-cancer agent capable of inducingferroptosis in melanoma cells.

In this study, we identified whether atorvastatin could induce ferroptosis or not in B16F10.OVA cells, whichis being used to treat hypercholesterolemia. To demonstrate this, we treated the mouse melanoma cell line B16F10.OVAwith atorvastatin at varying concentrations, spanning from low to high, followed by a 24-hour culture period. In the grouptreated with atorvastatin in our experiment, we observed a decrease in cell viability that was dependent on theconcentration of the treatment, when compared to the control group. The IC50 value of atorvastatin in B16F10.OVA cellswas determined to be 49.89 μM. Compared to the control group, treatment with atorvastatin resulted in a concentrationdependentincrease in the generation of reactive oxygen species and the accumulation of iron ions. Moreover, atorvastatintreatment exhibited a concentration-dependent increase in the population of apoptotic cells and the expression ofcalreticulin, significantly surpassing that of the control group. The analysis of ferroptosis-related protein expression levelsrevealed a notable decrease in the expression of GPX4 in the group treated with atorvastatin, as compared to the controlgroup. These findings strongly suggest that atorvastatin holds promise as a potent anti-cancer agent capable of inducingferroptosis in melanoma cells.

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B16F10.OVA cell에서 Atorvastatin에 의한 Ferroptosis 유도 규명 = Identification of ferroptosis induction by treating atorvastatin in B16F10.OVA cells 김민석, 임인호, 정윤화, 김승현, 조영창, 최정욱 p. 261-267

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참고문헌 (22건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
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2 Yu D, Liao JK (2022) Emerging views of statin pleiotropy and cholesterol lowering. Cardiovasc Res 118(2): 413-423. 미소장
3 Xu H, Zhou S, Tang Q, Xia H, Bi F (2020). Cholesterol metabolism: New functions and therapeutic approaches in cancer. Biochim Biophys Acta Rev Cancer 1874(1): 188394. 미소장
4 Subedi L, Pandey P, Khadka B, Shim JH, Cho SS, Kweon S, Byun Y, Kim KT, Park JW (2022) Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids. Drug Deliv 29(1): 3397-3413. 미소장
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8 Abolghasemi R, Ebrahimi-Barough S, Bahrami N, Ai J (2022) Atorvastatin Inhibits Viability and Migration of MCF7 Breast Cancer Cells. Asian Pac J Cancer Prev 23(3): 867-875. 미소장
9 Zhang X, Coker OO, Chu ES, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J (2021) Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut 70(4): 761-774. 미소장
10 Cai S, Gao Z (2021) Atorvastatin inhibits proliferation and promotes apoptosis of colon cancer cells via COX-2/PGE2/β-Catenin Pathway. J BUON 26(4): 1219-1225. 미소장
11 Longo J, van Leeuwen JE, Elbaz M, Branchard E, Penn LZ (2020) Statins as Anticancer Agents in the Era of Precision Medicine. Clin Cancer Res 26(22): 5791-5800. 미소장
12 Wang Y, Liu T, Li X, Sheng H, Ma X, Hao L (2021) Ferroptosis-Inducing Nanomedicine for Cancer Therapy. Front Pharmacol 12: 735965. 미소장
13 Wen J, Chen H, Ren Z, Zhang P, Chen J, Jiang S (2021) Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway. Nano Converg 8(1): 10. 미소장
14 Zhu L, You Y, Zhu M, Song Y, Zhang J, Hu J, Xu X, Xu X, Du Y, Ji J (2022) Ferritin-Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy. Adv Mater 34(51): e2207174. 미소장
15 Yang WS, Stockwell BR (2016) Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol 26(3): 165-176. 미소장
16 Lee JY, Kim WK, Bae KH, Lee SC, Lee EW (2021) Lipid Metabolism and Ferroptosis. Biology (Basel) 10(3): 184. 미소장
17 Li FJ, Long HZ, Zhou ZW, Luo HY, Xu SG, Gao LC (2022) System X(c) (-)/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy. Front Pharmacol 13: 910292. 미소장
18 Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G (2020) Ferroptosis: past, present and future. Cell Death Dis 11(2): 88. 미소장
19 Du Y, Guo Z (2022) Recent progress in ferroptosis: inducers and inhibitors. Cell Death Discov 8(1): 501. 미소장
20 Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P, Vandenabeele P (2012) Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer 12(12): 860-875. 미소장
21 Kielbik M, Szulc-Kielbik I, Klink M (2021) Calreticulin-Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients. Cells 10(1):130. 미소장
22 Zheng X, Jin X, Ye F, Liu X, Yu B, Li Z, Zhao T, Chen W, Liu X, Di C, Li Q (2023) Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy. Exp Hematol Oncol 12(1): 65. 미소장

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