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초록보기

DNA methylation is one of the most extensively studied epigenetic regulatory mechanisms, known to play crucial roles in various organisms. It has been implicated in the regulation of gene expression and chromatin changes, ranging from global alterations during cell state transitions to locus-specific modifications. 5-hydroxymethylcytosine (5hmC) is produced by a major oxidation, from 5-methylcytosine (5mC), catalyzed by the ten-eleven translocation (TET) enzymes, and is gradually being recognized for its significant role in genome regulation. With the development of state-of-the-art experimental techniques, it has become possible to detect and distinguish 5mC and 5hmC at base resolution. Various techniques have evolved, encompassing chemical and enzymatic approaches, as well as third generation sequencing techniques. These advancements have paved the way for a thorough exploration of the role of 5hm Cacross a diverse array of cell types, from embryonic stem cells (ESCs) to various differentiated cells. This review aims to comprehensively report on recent techniques and discuss the emerging roles of 5hmC.

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기사명 저자명 페이지 원문 목차
Whole-genome doubling is a double-edged sword : the heterogeneous role of whole-genome doubling in various cancer types Eunhyong Chang, Joon-Yong An p. 125-134

Detecting DNA hydroxymethylation : exploring its role in genome regulation Sun-Min Lee p. 135-142

Genistein alleviates pulmonary fibrosis by inactivating lung fibroblasts Seung-hyun Kwon, Hyunju Chung, Jung-Woo Seo, Hak Su Kim p. 143-148

Stomach clusterin as a gut-derived feeding regulator Cherl NamKoong, Bohye Kim, Ji Hee Yu, Byung Soo Youn, Hanbin Kim, Evonne Kim, So Young Gil, Gil Myoung Kang, Chan Hee Lee, Young-Bum Kim, Kyeong-Han Park, Min-Seon Kim, Obin Kwon p. 149-154

Calnexin as a dual-role biomarker : antibody-based diagnosis and therapeutic targeting in lung cancer Soyeon Lim, Youngeun Ha, Boram Lee, Junho Shin, Taiyoun Rhim p. 155-160

Exploring the DNA methylome of Korean patients with colorectal cancer consolidates the clinical implications of cancer-associated methylation markers Sejoon Lee, Kil-yong Lee, Ji-Hwan Park, Duck-Woo Kim, Heung-Kwon Oh, Seong-Taek Oh, Jongbum Jeon, Dongyoon Lee, Soobok Joe, Hoang Bao Khanh Chu ... [et al.] p. 161-166

참고문헌 (48건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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