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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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This study aimed to elucidate the anti-colon cancer mechanism of ginsenoside Rg1 in vitro and in vivo. Cell viability rate was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tetrazolium assay. The inhibitory effect of ginsenoside Rg1 against CT26 cell proliferation gradually increased with increasing concentration. The in vivo experiments also demonstrated an antitumor effect. The monodansylcadaverine (MDC), transmission electron microscopy (TEM), and expression of autophagy marker proteins confirmed that ginsenoside Rg1 induced autophagy in vitro. Ginsenoside Rg1 induced autophagy death of CT26 cells, but this effect could be diminished by autophagy inhibitor (3-methyladenine, 3-MA). Additionally, in a xenograft model, immunohistochemical analysis of tumor tissues showed that the LC3 and Beclin-1 proteins were highly expressed in the tumors from the ginsenoside Rg1-treated nude mice, confirming that ginsenoside Rg1 also induced autophagy in vivo. Furthermoer, both in vivo and in vitro, the protein expressions of p-Akt, p-mTOR, and p-p70S6K were inhibited by ginsenoside Rg1, which was verified by Akt inhibitors. These results indicated that the mechanism of ginsenoside Rg1 against colon cancer was associated with autophagy through inhibition of the Akt/mTOR/p70S6K signaling pathway.

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기사명 저자명 페이지 원문 목차
Diet-induced gut dysbiosis and leaky gut syndrome Yu-Rim Chae, Yu Ra Lee, Young-Soo Kim, Ho-Young Park p. 747-756

Advances in culturomics research on the human gut microbiome : optimizing medium composition and culture techniques for enhanced microbial discovery Hye Seon Song, Yeon Bee Kim, Joon Yong Kim, Seong Woon Roh, Tae Woong Whon p. 757-764

Ozonated sunflower oil (OSO) alleviates inflammatory responses in oxazolone-induced atopic dermatitis (AD)-like mice and LPS-treated RAW 264.7 cells Su-Young Kim, Jung Ok Lee, Sue Lee, Jihye Heo, Kyung-Hyun Cho, Ashutosh Bahuguna, Kwang-Ho Yoo, Beom Joon Kim p. 765-773

Ginsenoside Rg1 induces autophagy in colorectal cancer through inhibition of the Akt/mTOR/p70S6K pathway Ruiqi Liu, Bin Zhang, Shuting Zou, Li Cui, Lin Lin, Lingchang Li p. 774-782

Fisetin-mediated perturbations of membrane permeability and intracellular pH in Candida albicans Younhee Kim p. 783-794

Autolysis of Pseudomonas aeruginosa quorum-sensing mutant is suppressed by Staphylococcus aureus through iron-dependent metabolism Shin-Yae Choi, In-Young Chung, Hee-Won Bae, You-Hee Cho p. 795-803

Establishment of a dual-vector system for gene delivery utilizing prototype foamy virus Soo-Yeon Cho, Yoon Jae Lee, Seong-Mook Jung, Young Min Son, Cha-Gyun Shin, Eui Tae Kim, Kyoung-Dong Kim p. 804-811

Phloroglucinol enhances anagen signaling and alleviates H2O2-induced oxidative stress in human dermal papilla cells Seokmuk Park, Ye Jin Lim, Hee Su Kim, Hee-Jae Shin, Ji-Seon Kim, Jae Nam Lee, Jae Ho Lee, Seunghee Bae p. 812-827

Efficacy assessment of the co-administration of vancomycin and metronidazole in clostridioides difficile-infected mice based on changes in intestinal ecology Saiwei Zhong, Jingpeng Yang, He Huang p. 828-837

Oral administration of alcohol-tolerant lactic acid bacteria alleviates blood alcohol concentration and ethanol-induced liver damage in rodents Misun Yun, Hee Eun Jo, Namhee Kim, Hyo Kyeong Park, Young Seo Jang, Ga Hee Choi, Ha Eun Jo, Jeong Hyun Seo, Ji Ye Mok, Sang Min Park, Hak-Jong Choi p. 838-845

Optimization of ultrasound-assisted pretreatment for accelerating rehydration of adzuki bean (Vigna angularis) Hyengseop Kim, Changgeun Lee, Eunghee Kim, Youngje Jo, Jiyoon Park, Choongjin Ban, Seokwon Lim p. 846-853

Lactobacillus persisters formation and resuscitation Hyein Kim, Sejong Oh, Sooyeon Song p. 854-862

Taxonomic variations of bacterial and fungal communities depending on fermentation temperature in traditional Korean fermented soybean food, doenjang Eunhye Jo, Hyeyoung Lee, Younshil Song, Jaeho Cha p. 863-870

Genomic characterization and safety assessment of Bifidobacterium breve BS2-PB3 as functional food Kristin Talia Marbun, Marcelia Sugata, Jonathan Suciono Purnomo, Dikson, Samuel Owen Mudana, Tan Tjie Jan, Juandy Jo p. 871-879

Unveiling immunomodulatory effects of Euglena gracilis in immunosuppressed mice : transcriptome and pathway analysis Seon Ha Jo, Kyeong Ah Jo, Soo-yeon Park, Ji Yeon Kim p. 880-890

Improving the three-dimensional printability of potato starch loaded onto food ink Yourim Oh, Seungmin Lee, Nam Keun Lee, Jin-Kyu Rhee p. 891-901

Heat-killed Enterococcus faecium KU22001 having effective anti-cancer effects on HeLa cell lines at a lower temperature Jun-Su Ha, Na-Kyoung Lee, Hyun-Dong Paik p. 902-910

1-kestose blocks UVB-induced skin inflammation and promotes type Ⅰ procollagen synthesis via regulating MAPK/AP-1, NF-κB and TGF-β/Smad pathway Jihye Baek, Jong-Hwa Kim, Jiwon Park, Do Hyun Kim, Soonok Sa, Jung-Sook Han, Wonyong Kim p. 911-919

Transcription factor E2F7 hampers the killing effect of NK cells against colorectal cancer cells via activating RAD18 transcription Bingdong Jiang, Binghua Yan, Hengjin Yang, He Geng, Peng Li p. 920-929

Secretory production of the Hericium erinaceus Laccase from Saccharomyces cerevisiae Jin Kang, Thuat Van La, Mi-Jin Kim, Jung-Hoon Bae, Bong Hyun Sung, Seonghun Kim, Jung-Hoon Sohn p. 930-939

In vitro anti-inflammatory and skin protective effects of Codium fragile extract on macrophages and human keratinocytes in atopic dermatitis A-yeong Jang, JeongUn Choi, Weerawan Rod-in, Ki Young Choi, Dae-Hee Lee, Woo Jung Park p. 940-948

Melanin inhibitory effect of Tuber himalayense isolated in Incheon, Korea Byeong Min Choi, Minkyeong Kim, Hyehyun Hong, Tae-Jin Park, Changmu Kim, Jin-Soo Park, Won-Jae Chi, Seung-Young Kim p. 949-957

Prognostic value of an immune long non-coding RNA signature in liver hepatocellular carcinoma Rui Kong, Nan Wang, Chun Li Zhou, Jie Lu p. 958-968

Tryptophan-based hyperproduction of bioindigo by combinatorial overexpression of two different tryptophan transporters Hyun Jin Kim, Sion Ham, Nara-Shin, Jeong Hyeon Hwang, Suk Jin Oh, Tae-Rim Choi, Jeong Chan Joo, Shashi Kant Bhatia, Yung-Hun Yang p. 969-977

Intracellular flux prediction of recombinant Escherichia coli producing gamma-aminobutyric acid Sung Han Bae, Myung Sub Sim, Ki Jun Jeong, Dan He, Inchan Kwon, Tae Wan Kim, Hyun Uk Kim, Jong-il Choi p. 978-984

참고문헌 (24건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition 미소장
2 Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κB-dependent MMP-9 expression 미소장
3 Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2 미소장
4 Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway 미소장
5 Oncogenic Roles of the PI3K/AKT/mTOR Axis 미소장
6 Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells 미소장
7 Dual role of autophagy in hallmarks of cancer 미소장
8 Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition 미소장
9 Detection of 13 Ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg3, Rh2, F1, Compound K, 20(S)-Protopanaxadiol, and 20(S)-Protopanaxatriol) in Human Plasma and Application of the Analytical Method to Human Pharmacokinetic Studies Following Two Week-Repeated Administration of Red Ginseng Extract 미소장
10 PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside 미소장
11 Targeting autophagy-related protein kinases for potential therapeutic purpose 미소장
12 At a glance: A history of autophagy and cancer 미소장
13 Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells 미소장
14 Targeted antitumor activity of Ginsenoside (Rg1) in paclitaxel-resistant human nasopharyngeal cancer cells are mediated through activation of autophagic cell death, cell apoptosis, endogenous ROS production, S phase cell cycle arrest and inhibition of m-TOR/PI3K/AKT signalling pathway. 미소장
15 RETRACTED: Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway 미소장
16 Babaodan inhibits cell growth by inducing autophagy through the PI3K/AKT/mTOR pathway and enhances antitumor effects of cisplatin in NSCLC cells. 미소장
17 Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis 미소장
18 Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII‐Induced Anticancer Effects in Human Osteosarcoma Cells 미소장
19 Ginsenoside Rg1 prevent and treat inflammatory diseases: A review 미소장
20 Ginsenoside Rg3 Suppresses Epithelial-Mesenchymal Transition via Downregulating Notch-Hes1 Signaling in Colon Cancer Cells 미소장
21 E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer 미소장
22 Machinery, regulation and pathophysiological implications of autophagosome maturation 미소장
23 Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? 미소장
24 Colorectal cancer 미소장

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