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Serum and glucocorticoid-regulated kinases (SGKs) are members of the AGC kinase family and consist of three isoforms: SGK1, SGK2, and SGK3. SGK1 is a potential target for cancer therapy because the overexpression of SGK1 has caused irregular cell proliferation, leading to solid human tumors. This study has investigated the structure-activity relationship (SAR) of a series of novel pyrrolo[2,3-b]pyridine derivatives with potential anticancer activity. Eighteen compounds were synthesized and evaluated for their inhibitory activities against SGK1, 2 and 3. SAR analysis was performed in order to identify the key structural features influencing the bioactivity of the compounds.

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기사명 저자명 페이지 원문 목차
Implementation of an air quality monitoring system and prediction using LSTM ensemble modeling for the availability of multi-use facilities of health-vulnerable groups : a preliminary study Kwang Hyeon Kim, Hae-Won Koo, Jae-Keun Cho, Je-Hyeon Song, Se-Hyeong Jeon p. 11-22

Kyobo Book Center customer segmentation using K-means cluster analysis Suji Kang, Yonghyeok Lee, Sunghwan Kim, Changha Hwang p. 1-9

Generalized additive model using deep neural networks with self-attention module Jooyong Shim, Changha Hwang, Hyejung Park, Heesoo Kim, Kyungha Seok p. 23-27

Exploration and advancements in synthetic control method Heesoo Kim, Jooyong Shim, Kyungha Seok p. 29-37

Analysis of dough structure changes induced by polyphenols via FTIR spectroscopy Bong Kyung Koh p. 39-43

Investigation of the relationship between anticonvulsants for seizures and genes using artificial intelligence modeling and topic analysis Kwang Nam Kim, Kwang Hyeon Kim p. 45-52

Synthesis and characterization of 5,5-disubstituted-5H-dibenzo[b,d]siloles Min Kyoung Kim, Young Tae Park p. 53-60

Novel pyrrolo[2,3-b]pyridine derivatives as SGK1 inhibitors Mingyu Jeon, Dagyu Kang, Jieun Kim, Victor Sukbong Hong, Jinho Lee p. 61-69

Analysis of Russia-Ukraine war dynamics via local identification Byeongseon Jeong p. 71-78

Time fractional reaction-diffusion system with Caputo-Fabrizio derivative using Mellin transform Sihun Jo, Ana Yun p. 79-85

From time series to topology : advancing League of Legends win prediction with vietoris-rips persistents homology Daewon Chung p. 87-93

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