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BACKGROUND/OBJECTIVES: This study evaluated the beneficial effects of an ethanol extract of Boswellia serrata gum resin (FJH-UBS) in osteoporosis.

MATERIALS/METHODS: MC3T3-E1 osteoblastic cells and RAW 264.7 osteoclastic cells were treated with FJH-UBS. The alkaline phosphatase (ALP) activity, mineralization, collagen synthesis, osteocalcin content, and Runt-related transcription factor 2 (RUNX2) and Osterix expression were measured in MC3T3-E1 cells. The actin ring structures, tartrate-resistant acid phosphatase (TRAP) activity, and the nuclear factor of activator T-cells, cytoplasm 1 (NFATc1) expression were evaluated in RAW 264.7 cells. Ovariectomized ICR mice were orally administered FJH-UBS for eight weeks. The bone mineral density (BMD) and the serum levels of osteocalcin, procollagen 1 N-terminal propeptide (P1NP), osteoprotegerin, and TRAP 5b were analyzed.

RESULTS: FJH-UBS increased the ALP activity, collagen, osteocalcin, mineralization, and RUNX2 and osterix expression in MC3T3-E1 osteoblastic cells, whereas it decreased the TRAP activity, actin ring structures, and NFATc1 expression in RAW 264.7 osteoclastic cells. In ovariectomy-induced osteoporosis mice, FJH-UBS positively restored all of the changes in the bone metabolism biomarkers (BMD, osteocalcin, P1NP, osteoprotegerin, and TRAP 5b) caused by the ovariectomy.

CONCLUSION: FJH-UBS has anti-osteoporotic activity by promoting osteoblast activity and inhibiting osteoclast activity in vitro and in vivo, suggesting that FJH-UBS is a potential functional food ingredient for osteoporosis.

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기사명 저자명 페이지 원문 목차
Anti-osteoporotic effects of Boswellia serrata gum resin extract in vitro and in vivo Hyun Sook Lee, Jae In Jung, In-Kee Hong, YoungSun Jang, Hye-Bin Kim, Eun Ji Kim p. 309-324

Kaempferol ameliorates metabolic syndrome by inhibiting inflammation and oxidative stress in high-fat diet-induced obese mice Su-Kyung Shin, Eun-Young Kwon p. 325-344

Hypoglycemic and hypolipidemic effects of unsaponifiable matter from okra seed in diabetic rats Dongyeon Seo, Naeun Kim, Ahyeong Jeon, Jihyun Kwon, In-hwan Baek, Eui-Cheol Shin, Junsoo Lee, Younghwa Kim p. 345-356

Liquid collagen from freshwater fish skin ameliorates hydration, roughness and elasticity in photo-aged skin : a randomized, controlled, clinical study Joong Su Lee, Yeo Cho Yoon, Ju Myung Kim, Yun-Ho Kim, Young-Hee Kang, Yong Chul Shin p. 357-371

Development of a frailty prevention program including nutrition and exercise interventions for older adults in senior daycare centers in South Korea using a mixed methods research design Jiwon Sim, Jongguk Lim, Eunji Ko, Eunjin Jang, Minjeong Jeong, Sohyun Park p. 372-386

Relationships among tooth loss, prefrailty, and dietary patterns in community-dwelling older Japanese females : a cross-sectional study Tatsumi Hayashi, Rumi Sato, Kazuo Tamura p. 387-399

Malnutrition and its associated factors among community-dwelling older men living alone Gahye Kim, Minhwa Hwang, Seonghyeon Lee, Yeon-Hwan Park p. 400-411

Iodine intake from brown seaweed and the related nutritional risk assessment in Koreans Sung Ok Kwon, Kwang-Il Kwon, Mi-Young Lee, Hye Young Lee, Cho-il Kim p. 412-424

(A) study on the relationship between purchases of meal kits and home meal replacements Jong-Youn Rha, Haerang Lee, Sohyun Kim, Youngwon Nam p. 425-435

(A) combination of myokines and genistein suppresses cancer stemness in MCF-7 human breast cancer cells Hyeji Kwon, Yuri Kim, Jung Hyun Kim p. 436-445

참고문헌 (42건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
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