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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Purpose The role of allogeneic stem cell transplantation (alloSCT) in multiple myeloma (MM) treatment remains controversial. We conducted a retrospective, multicenter, nationwide study in Korea to evaluate the outcomes of alloSCT in Asian patients with MM.

Materials and Methods Overall, 109 patients with MM who underwent alloSCT between 2003 and 2020 were included in this study. Data were collected from the Korean Multiple Myeloma Working Party Registry.

Results The overall response rate and stringent complete response plus complete response (CR) rates were 67.0 and 46.8%, respectively, after alloSCT. At a median follow-up of 32.5 months, the 3-year probability of progression-free survival (PFS) and overall survival (OS) rates were 69.3% and 71.8%, respectively. The 3-year probabilities of OS rates in the upfront alloSCT, tandem auto-alloSCT, and later alloSCT groups were 75.0%, 88.9%, and 61.1%, respectively. Patients who achieved CR before or after alloSCT had significantly longer OS (89.8 vs. 18 months and 89.8 vs. 15.2 months, respectively). Even though patients who did not achieve CR prior to alloSCT, those who achieve CR after alloSCT had improved PFS and OS compared to those who had no achievement of CR both prior and after alloSCT. Patients who underwent alloSCT with 1-2 prior treatment lines had improved PFS (22.4 vs. 4.5 months) and OS (45.6 vs. 15.3 months) compared to those with three or more prior treatment lines.

Conclusion AlloSCT may be a promising therapeutic option especially for younger, chemosensitive patients with earlier implementation from relapse.

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(The) role of early and delayed surgery for infants with congenital brain tumors Jong Seok Lee, Ji Yeoun Lee, Kyung Hyun Kim, Sung-Hye Park, Eun Jung Koh, Seung-Ki Kim, Ji Hoon Phi p. 909-919

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참고문헌 (28건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 J Korean Med Sci. 2007 Apr;22(2):227-34 미소장
2 Biol Blood Marrow Transplant. 2016 Oct;22(10):1893-1899 미소장
3 Bone Marrow Transplant. 2015 Apr;50(4):505-10 미소장
4 Bone Marrow Transplant. 2014 Mar;49(3):416-21 미소장
5 J Clin Oncol. 2010 Oct 10;28(29):4521-30 미소장
6 Biol Blood Marrow Transplant. 2013 Jun;19(6):860-6 미소장
7 Bone Marrow Transplant. 2017 Dec;52(12):1602-1608 미소장
8 Cancer. 2006 Mar 1;106(5):1084-9 미소장
9 Blood. 2005 Nov 1;106(9):2969-76 미소장
10 Bone Marrow Transplant. 2008 Jun;41(11):953-60 미소장
11 Blood. 2008 Nov 1;112(9):3591-3 미소장
12 Leukemia. 2006 Sep;20(9):1467-73 미소장
13 Transplantation. 1974 Oct;18(4):295-304 미소장
14 Haematologica. 2007 Nov;92(11):1513-8 미소장
15 Blood. 2009 Apr 2;113(14):3383-91 미소장
16 Transfus Apher Sci. 2016 Feb;54(1):63-70 미소장
17 Bone Marrow Transplant. 2009 Sep;44(5):325-6 미소장
18 Biol Blood Marrow Transplant. 2018 Jul;24(7):1392-1398 미소장
19 Blood. 2008 Mar 1;111(5):2516-20 미소장
20 Br J Haematol. 2001 Apr;113(1):209-16 미소장
21 N Engl J Med. 2011 Mar 17;364(11):1046-60 미소장
22 Bone Marrow Transplant. 2013 Nov;48(11):1395-400 미소장
23 Biol Blood Marrow Transplant. 2015 Dec;21(12):2039-2051 미소장
24 Biol Blood Marrow Transplant. 2007 Aug;13(8):925-31 미소장
25 Biol Blood Marrow Transplant. 2013 Oct;19(10):1453-8 미소장
26 Blood. 2004 Jan 1;103(1):20-32 미소장
27 Biol Blood Marrow Transplant. 2012 Apr;18(4):617-26 미소장
28 Leukemia. 2014 Mar;28(3):525-42 미소장

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