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결과 내 검색 동의어 포함

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초록보기

종양 억제 유전자(TSG)는 세포 항상성을 유지하는 데 중요한 역할을 한다. 이러한 유전자의 기능이 상실되면 세포 가소성(cellular plasticity)이 유발되어 다양한 암, 특히 공격적인 성향을 가진 소세포 폐암(SCLC)이 발생할 수 있다. SCLC는 주로 후성학적 조절인자를 암호화하는 유전자에서 발생하는 다수의 기능 상실 돌연변이에 의해 유발된다. 이러한 돌연변이는 직접적으로 표적화하기 어렵기 때문에 치료제 개발이 어려운 상황이다. 그러나 이러한 돌연변이로 인한 분자적 변화를 이해하면 종양 치료 전략을 개발하는데 큰 도움이 될 수 있다. 우리는 SCLC의 이질적인 유전체 환경에도 불구하고 환자의 종양에서 발생하는 돌연변이의 영향이 악성 종양을 유발하는 몇 가지 중요한 경로로 수렴되고 있음을 확인하였다. 특히, 후성학적 변화는 전사 조절 장애를 초래하여 돌연변이 세포가 면역 회피 및 높은 전이 능력을 가진 매우 가소성이 높은 상태로 진입하게 한다. 본 논문에서는 반대 기능을 가진 후성학적 조절인자의 불균형이 면역 인식 마커의 상실로 이어져 종양 세포가 면역 체계로부터 효과적으로 회피하는 과정을 보여주는 연구들을 강조하였다. 또한 후성학적 조절인자가 신경내분비 세포 특성을 유지하는 역할과 비정상적인 전사 조절이 종양의 발달 및 진행 중 상피간엽이행(EMT)를 촉진하는 방법에 대해 서술하였다. 이 경로들은 별개의 것처럼 보이지만, 흔히 공통된 분자와 매개체를 공유하고 있음을 확인하였다. 빈번하게 변화하는 후성학적 조절인자 간의 연결을 이해하면 SCLC 및 유사한 돌연변이를 가진 다른 암의 발달과 진행의 분자적 메커니즘에 대한 귀중한 통찰력을 제공하여 예방 및 치료법 개발에 기여할 수 있을 것이다.

Tumor suppressor genes (TSGs) play a crucial role in maintaining cellular homeostasis. When the function of these genes is lost, it can lead to cellular plasticity that drives the development of various cancers, including small-cell lung cancer (SCLC), which is known for its aggressive nature. SCLC is primarily driven by numerous loss-of-function mutations in TSGs, often involving genes that encode epigenetic regulators. These mutations pose a significant therapeutic challenge as they are not directly targetable. However, understanding the molecular changes resulting from these mutations might provide insights for developing tumor intervention strategies. We propose that despite the heterogeneous genomic landscape of SCLC, the effects of mutations in patient tumors converge on a few critical pathways that drive malignancy. Specifically, alterations in epigenetic regulators lead to transcriptional dysregulation, pushing mutant cells toward a highly plastic state that makes them immune evasive and highly metastatic. This review will highlight studies showing how an imbalance of epigenetic regulators with opposing functions leads to the loss of immune recognition markers, effectively hiding tumor cells from the immune system. Additionally, we will discuss the role of epigenetic regulators in maintaining neuroendocrine features and how aberrant transcriptional control promotes epithelial-to-mesenchymal transition during tumor development. Although these pathways seem distinct, we emphasize that they often share common molecular drivers and mediators. Understanding the connection among frequently altered epigenetic regulators will provide valuable insights into the molecular mechanisms underlying SCLC development, potentially revealing preventive and therapeutic vulnerabilities for SCLC and other cancers with similar mutations.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
L-AHG-mediated suppression of M1 polarization and pro-inflammatory signaling pathways in LPS-stimulated RAW264.7 macrophages = LPS에 의해 자극된 RAW264.7 대식세포에서 L-AHG에 의한 M1 분극화 및 친염증 신호 경로의 억제 Won Young Jang, Shin Young Park, Ki Youn Kim, Do Youn Jun, Young-Seuk Bae, Young Ho Kim p. 443-452

메주의 크기에 따른 간장의 미생물 군집 변화 양상 분석 = Analysis of microbial community change in ganjang according to the size of meju 정호진, 하광수, 이란희, 정도연, 양희종 p. 453-464

Lactiplantibacillus plantarum K9 유전체 분석을 통해 필수 물질대사 경로의 탐색 = Examination of the central metabolic pathway with genomics in Lactiplantibacillus plantarum K9 김삼웅, 김영진, 최효인, 이상원, 지원재, 방우영, 김태완, 방규호, 갈상완 p. 465-475

ROS 의존적 세포사멸 유도를 통한 isoalantolactone의 인간 간세포암종 Hep3B 세포 유래 다세포 종양 spheroid 형성의 억제 = Isoalantolactone inhibits the formation of multicellular tumor spheroids derived from human hepatocellular carcinoma Hep3B cells through the induction of ROS-dependent apoptosis 김민영, 손변우, 이상엽, 박상은, 홍수현, 홍상훈, 김은정, 최영현, 황보현 p. 476-484

발효해삼의 항산화 및 면역강화 기능성 물질의 분석 = Examination of antioxidant and immune-enhancing functional substances in fermented sea cucumber 김삼웅, 김가희, 김범철, 이유빈, 이가빈, 갈상완, 김철호, 방우영, 방규호 p. 485-492

대장균에서 항균 펩타이드 stomoxyn을 생산하기 위한 형질전환 벡터 제작 = Construction of a plant chloroplast transformation vector to produce the antimicrobial peptide stomoxyn 고진규, 길현호, 김순영 p. 493-499

염촉매 전기분해 공기살균기의 효능 평가 = Efficacy and safety evaluation of an air sterilizer equipped with an electrolytic salt catalyst for the removal of indoor microbial pollutants 유선녕, 전호연, 김부경, 김애리, 정경일, 전계록, 안순철 p. 500-508

Scopolamine 유도 인지 저하 마우스 모델에서 크릴 오일의 인지 개선 효과 = Cognitive improvement effects of krill oil in a scopolamine-induced mice model 설혜민, 이정아, 황미선, 박상훈, 김형수 p. 509-519

소세포폐암의 미세환경에서 후성학적 조절인자의 역할에 대한 최신 연구 동향 = Recent findings on the role of epigenetic regulators in the small-cell lung cancer microenvironment 정민호, 김기범 p. 520-530

참고문헌 (68건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
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