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국회도서관 홈으로 정보검색 소장정보 검색

초록보기

The nucleus, a highly organized and dynamic organelle, plays a crucial role in regulating cellular processes. During cell differentiation, profound changes occur in gene expression, chromatin organization, and nuclear morphology. This review explores the intricate relationship between nuclear architecture and cellular function, focusing on the roles of the nuclear lamina, nuclear pore complexes (NPCs), sub-nuclear bodies, and the nuclear scaffold. These components collectively maintain nuclear integrity, organize chromatin, and interact with key regulatory factors. The dynamic remodeling of chromatin, its interactions with nuclear structures, and epigenetic modifications work in concert to modulate gene accessibility and ensure precise spatiotemporal control of gene expression. The nuclear lamina stabilizes nuclear shape and is associated with inactive chromatin regions, while NPCs facilitate selective transport. Sub-nuclear bodies contribute to genome organization and gene regulation, often by influencing RNA processing. The nuclear scaffold provides structural support, impacting 3D genome organization, which is crucial for proper gene expression during differentiation. This review underscores the significance of nuclear architecture in regulating gene expression and guiding cell differentiation. Further investigation into nuclear structure and 3D genome organization will deepen our understanding of the mechanisms governing cell fate determination.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Nuclear structures and their emerging roles in cell differentiation and development Hye Ji Cha p. 381-387

Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy Seon Ah Lim p. 388-399

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Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway Jiwon Ko, Soyoung Jang, Soyeon Jang, Song Park, Junkoo Yi, Dong Kyu Choi, Seonggon Kim, Myoung Ok Kim, Su-Geun Lim, Zae Young Ryoo p. 417-423

Development of a highly effective recombinant protein from human collagen type Ⅲ alpha 1 (COL3A1) to enhance human skin cell functionality Young Un Kim, HyunJoon Gi, Eun Kyung Jeong, Seokwon Han, Woo-Young Seo, Young Jun Kim, Sang Bae Lee, KyeongJin Kim p. 424-429

참고문헌 (70건) : 자료제공( 네이버학술정보 )

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