본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Organoids, three-dimensional structures developed from pluripotent or adult stem cells, haveemerged as a transformative tool for modelling human tissues in vitro. These models more accuratelymimic key features of native organs than traditional cell cultures or animal models,better aiding in the understanding of human-specific physiology and disease mechanisms. Gastrointestinalorganoids have demonstrated considerable utility in drug discovery and screening,personalized medicine, and research on organ development, carcinogenesis, and host–microbiotainteractions. Their relevance in the domains of drug screening and toxicological testingcontinues to expand, especially as efforts to reduce interspecies variability and euthanasia inpreclinical research grow. This review underscores significant milestones in the developmentand application of gastrointestinal organoids, particularly those derived from colon and colorectalcancer tissues, for drug testing and toxicity assessment. Colorectal cancer organoids allowfor the capture of patient-specific heterogeneity and have facilitated personalized approaches totherapeutic assessment. Despite persistent challenges, including limited immune and stromalintegration and technical inconsistencies across laboratories, recent advancements, such as coculturetechniques, organ-on-a-chip systems, and bioengineered matrices, have broadened theapplicability of organoids. Building on these technological advancements, organoid technologyis expected to play an increasingly significant role in advancing precision medicine for colorectalcancer and in developing human-relevant toxicity assessment strategies.

Organoids, three-dimensional structures developed from pluripotent or adult stem cells, haveemerged as a transformative tool for modelling human tissues in vitro. These models more accuratelymimic key features of native organs than traditional cell cultures or animal models,better aiding in the understanding of human-specific physiology and disease mechanisms. Gastrointestinalorganoids have demonstrated considerable utility in drug discovery and screening,personalized medicine, and research on organ development, carcinogenesis, and host–microbiotainteractions. Their relevance in the domains of drug screening and toxicological testingcontinues to expand, especially as efforts to reduce interspecies variability and euthanasia inpreclinical research grow. This review underscores significant milestones in the developmentand application of gastrointestinal organoids, particularly those derived from colon and colorectalcancer tissues, for drug testing and toxicity assessment. Colorectal cancer organoids allowfor the capture of patient-specific heterogeneity and have facilitated personalized approaches totherapeutic assessment. Despite persistent challenges, including limited immune and stromalintegration and technical inconsistencies across laboratories, recent advancements, such as coculturetechniques, organ-on-a-chip systems, and bioengineered matrices, have broadened theapplicability of organoids. Building on these technological advancements, organoid technologyis expected to play an increasingly significant role in advancing precision medicine for colorectalcancer and in developing human-relevant toxicity assessment strategies.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
위암 발생과 수면장애 = Sleep disorders and gastric cancer 김진옥, 김연지 p. 93-98
Glucagon-like Peptide-1 수용체작용제와 위장관 종양 = Glucagon-like peptide-1 receptor agonists and gastrointestinal neoplasms 김유진, 배재현 p. 99-106
비침습적 검사를 이용한 대장암 검진 = Recent advances in noninvasive tests for colorectal cancer screening : 최신 연구 결과 중심으로 소재승 p. 107-111
조기 발병 대장암의 역학, 위험요인 및 예후 = Early-onset colorectal cancer : epidemiology, risk factors, and prognosis 이승범 p. 112-119
Diagnosis and management of intraductal papillary mucinous neoplasms : focusing on precancerous lesions See Young Lee, Chan Min Jung, Jung Hyun Jo, Sung Ill Jang, Jae Hee Cho p. 120-130
절제불가능한 비기능성 Grade 1–2 췌장 신경내분비종양에 대한 전신 치료 = Systemic therapy of unresectable non-functioning pancreatic neuroendocrine tumor : focusing on grade 1–2 박남영, 성민제 p. 131-142
Clinical applicability of artificial intelligence-based early detection and prognosis assessment in pancreatic cancer Youngjung Kim p. 143-149
C형간염 간세포암종에서의 Direct-acting Antivirals 치료 = Direct-acting antivirals therapy for hepatocellular carcinoma in hepatitis C patients : 최근 근거 기반 고찰 한슬기, 백순구, 김문영 p. 150-156
줄기세포 오가노이드를 이용한 소화기 암 모델링 최신 연구 동향 = Recent research trends in modeling digestive cancer using stem cell organoids 김한수, 허정훈 p. 157-167
환자 유래 세포 기반 소화기암 오가노이드 제작과 맞춤형 치료 적용 = Construction and application of patient-derived organoid models for gastrointestinal cancer precision therapy 최형록, 최수민, 왕승원, 정진웅 p. 168-179
Applications of colorectal stem cell-derived organoids in drug testing and toxicity assessment Junsik Seo, Seongwoo Jeong, Yeongju Bae, Wooyoung Jeong p. 180-193
Metastatic small cell neuroendocrine carcinoma presenting with liver metastasis Hye Yeon Chon p. 194-196
췌장암에 대한 수술 전 항암화학요법으로서 FOLFIRINOX와 Gemcitabine/Nab-paclitaxel 용법에 대한 종양학적 치료결과 = Oncologic outcomes of FOLFIRINOX versus gemcitabine with nab-paclitaxel as a preoperative chemotherapy for pancreatic cancer 이윤석 p. 197-200
소화기암 환자 철결핍 빈혈(Iron Deficiency Anemia)의 관리 = Management of iron deficiency anemia in gastrointestinal cancer patient 이우주, 김은선 p. 201-202

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기