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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease whose diagnosis relies on clinical presentation and history due to the absence of definitive diagnostic tests or biomarkers. The Korean Atopic Dermatitis Association (KADA) recently updated its diagnostic criteria to enhance accuracy and applicability.

Objective: This study validates the updated KADA criteria by assessing their diagnostic performance in a clinical setting and comparing them with the previous KADA and Japanese Dermatological Association (JDA) criteria.

Methods: A multicenter, cross-sectional study was conducted with 231 AD patients and 81 non-AD controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden’s index, and error rates for the criteria and individual clinical features included were analyzed. Results: The updated KADA criteria demonstrated the highest sensitivity (63.20%) compared to the previous KADA (61.04%) and JDA criteria (47.62%), enabling better identification of a broader range of AD phenotypes. While its specificity (82.72%) was slightly lower than that of the previous KADA (88.89%) and JDA criteria (95.06%), the updated criteria maintained a strong PPV of 91.01% and a comparable NPV of 44.10%. The Youden’s index for the updated criteria was 0.459, indicating a balanced trade-off between sensitivity and specificity, and the error rate was the lowest (31.41%), underscoring its enhanced overall diagnostic accuracy.

Conclusion: The updated KADA criteria provide a practical and intuitive diagnostic tool, effectively addressing the limitations of previous criteria and improving the efficient and comprehensive diagnosis of AD, especially in those with diverse presentations.

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기사명 저자명 페이지 원문 목차
Microbiome-based interventions for skin aging and barrier function : a comprehensive review Ji Yeon Hong, Doyeon Kwon, Kui Young Park p. 259-268

Botulinum toxin A modulates keratinocyte proliferation and inflammatory and pruritic mediators in wound healing Dayeon Jung, SunMee Shin, Kwang Ho Kim, Kwang Joong Kim, Eun Joo Park p. 269-275

Differential modulation of skin barrier proteins and lipid synthesis by Staphylococcus aureus, Staphylococcus hominis, and Cutibacterium acnes Haivin Kim, Aram Kim, Hanyoung Kim, Dahye Seo, Suji Son, DongHyun Kim, Jung U Shin p. 276-285

Para-phenylenediamine sensitization and polysensitization : TNF-α, CXCL11, and immune-regulatory gene polymorphisms Jin Ju Lee, Heera Lee, Ji Yeon Byun, You Won Choi, Joo Young Roh, Hae Young Choi p. 286-293

Efficacy and safety of a PTPD-12–containing cream on improvement in hyperpigmentation : a randomized, split-face clinical trial Yu Jeong Bae, Shinwon Hwang, Il Joo Kwon, Jamal Mohammed Alqahtani, Eun Jung Lee, Ji Young Kim, Seohyun Park, Sang Ho Oh p. 294-299

Clinical validation of the updated Korean atopic dermatitis diagnostic criteria in a hospital setting in South Korea Seungah Yoo, Jaeeun Song, Jung Eun Kim, Ji Hae Lee, Hyun Ji Lee, Kyung Ho Lee, Yu Ri Woo, Young Bok Lee, Ji Hyun Lee, Sang Hyun Cho p. 300-306

Clinical efficacy and safety of baricitinib in patients with alopecia areata in Korea Jae Won Lee, Hyun-Tae Shin, Young Lee, Do-Young Kim, Jin Park, Gwang Seong Choi p. 307-313

Integrating anatomical site information into vision transformer models for skin cancer classification Dae-Lyong Ha, Sungmoon Jeong, Dongwon Woo, Jungrae Cho, Weon Ju Lee p. 314-316

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