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The phosphatidylinositol-3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway and microRNA (miRNA) regulation have been implicated in the initiation and progression of acute leukemia. Despite significant progress in the understanding of leukemogenic mechanisms, current therapies remain limited by relapse, drug resistance, and poor long-term survival, underscoring the need for novel targeted strategies. This review provides the current evidence regarding the molecular interplay between PI3K/AKT/mTOR signaling and miRNA dysregulation in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). We highlight key oncogenic and tumorsuppressive miRNAs, discuss their regulatory impact on critical genes (PIK3CA, AKT1, PTEN, and FMS-like tyrosine kinase 3 [FLT3]), and evaluate therapeutic approaches, including PI3K/AKT inhibitors and miRNA-based interventions. Furthermore, we identified existing controversies, methodological limitations, and unresolved research gaps. Finally, we emphasize the translational potential of miRNA-targeted therapies and pathway-specific inhibitors, providing insights into their integration into personalized treatment strategies for acute leukemia.

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Molecular spectrum and carrier frequency of deletional hereditary persistence of fetal hemoglobin and delta-beta thalassemia in Malaysia Faidatul Syazlin Abdul Hamid, Sabariah Md Noor, Mei I Lai, Samsol Kamal Mohd Bahari, Ezalia Esa, Ermi Neiza Mohd Sahid, Norafiza Mohd Yasin, Yuslina Mat Yusoff p. 1-8
Novel agents and evolving strategies for anemia management in lower-risk myelodysplastic syndromes Junshik Hong p. 1-7
Treatment of transplant-ineligible multiple myeloma Jongheon Jung p. 1-7
Tandem autologous stem cell transplant in multiple myeloma patients with minimal residual disease : an explorative study Sieun Oh, Sung-Soo Park, Jung Yeon Lee, Jae-Ho Yoon, Sung-Eun Lee, Hee-Je Kim, Seung-Hwan Shin, Young-Woo Jeon, Seung-Ah Yahng, Jin Jung, Ari Ahn, Myungshin Kim, Chang-Ki Min p. 1-10
Aggressive natural killer cell leukemia therapy in the L-asparaginase era : why are we failing? Sang Eun Yoon, Junhun Cho, Hyun-Young Kim, Seok Jin Kim, Won Seog Kim p. 1-13
Unveiling the role of microRNAs, the PI3K/AKT pathway, and their associations in various types of leukemia : a comprehensive review Amir Modarresi Chahardehi, Esfandiar Mali, Arya Afrooghe, Amirmasoud Asadi, Amirreza Khalaji, Hamed Soleimani Samarkhazan, Hananeh Esmaeil Beygi, Amirhossein Mohagheghi, Maryam Khanbabaei, Heliya Haghani, Reza Arefnezhad, Fatemeh RezaeiTazangi p. 1-13
Early CD4 + T cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou p. 1-10
Beyond anemia : unraveling neutrophil defects and infection susceptibility in β-Thalassemia Chingiz Asadov, Gunay Aliyeva p. 1-10
(Correspondence) Durable responses and favorable cost-effectiveness of rituximab‑based chemoimmunotherapy for primary cold agglutinin disease Kenichi Ito, Tomoko Kitagawa, Saya Motohashi, Kazuhiko Hirano, Naohiro Sekiguchi p. 1-6
(Correspondence) Current immunotherapeutic approaches for relapsed/refractory follicular lymphoma : bispecific antibodies and CAR T-Cell therapies So Yeon Park, Gi-June Min p. 1-6
(A) comparative study of hematologic response to ropeginterferon alfa-2b in hydroxyurea-resistant or intolerant polycythemia vera : a real-world data-based analysis Sung-Eun Lee, Seug Yun Yoon, Sung-Yong Kim, Soo-Mee Bang, Insoo Lee, Jihyuk Lee, Junshik Hong p. 1-7
Plasma interleukin : 12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia Wadhera Sarthak, Jain Arihant, Sahni Aarushi, Swain Rudra Narayan, Singh Charanpreet, Jandial Aditya, Aggarwal Ritu, Hans Rekha, Prakash Gaurav, Khadwal Alka, Grover Sandeep, Das Reena, Malhotra Pankaj p. 63-63
Brentuximab vedotin combined with cisplatin, cytarabine, and dexamethasone treatment in transplant : eligible Korean patients with relapsed or refractory Hodgkin’s lymphoma Yi Jun Ho, Park Young Hoon, Lee Myung-won, Yoo Kwai Han, Hong Junshik, Eom Hyeon-Seok p. 62-62
Insights into Treatment : Free Remission (TFR) outcomes in Chronic Myeloid Leukaemia (CML) – a tertiary centre experience in Malaysia Liam Christopher Chin Keong, Boo Yang Liang, Lim Li Min, Chong Siew Lian, Sharif Azizan, Wong Yih Seong, Selvaratnam Veena, Tan Sen Mui, Lim Soo Min p. 64-64
Invasive fungal infections in hematologic diseases : evidence, challenges, and clinical practice Cho Sung-Yeon, Lee Chae Eun, Nho Dukhee, Lee Dong-Gun p. 65-65
Measurable residual disease monitoring after hematopoietic stem cell transplantation Shin Saeam p. 66-66
Translational investigation of tolinapant (ASTX660) in acute myeloid leukemia by integrating clinical, bioinformatic and pharmacological approaches Lima Keli, Nogueira Frederico Lisboa, Reis-Silva Catarina Sofia Mateus, de Cássia Cavaglieri Rita, Costa-Lotufo Leticia Veras, Machado-Neto João Agostinho, Rego Eduardo Magalhães p. 67-67

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