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β-Thalassemia is characterized by defective β-globin synthesis and chronic transfusion dependence. Beyond anemia and iron overload, patients with β-thalassemia display heightened susceptibility to infections. Neutrophil granulocytes (NGs) are crucial innate immune cells that protect against bacteria through phagocytosis, degranulation, generation of reactive oxygen species (ROS), and neutrophil extracellular trap (NET) formation. Neutrophils in patients with thalassemia exhibit impaired functions, including defective chemotaxis, reduced phagocytic killing, attenuated respiratory burst, and abnormal NET formation. Chronic immune activation and iron overload, with consequent oxidative stress, are key contributors to these defects. Iron accumulation leads to excess free iron and heme, catalyzing ROS production that damages neutrophil membranes and enzymes and induces heme oxygenase-1 (HO-1), which suppresses immune responses. Neutrophils from patients with thalassemia often show an immature phenotype and increased apoptosis, further compromising innate immunity. A growing body of evidence confirms that systemic iron overload is inversely correlated with neutrophil bactericidal activity. These neutrophil defects contribute to the high risk of infection in thalassemia. Therapeutic strategies such as intensive iron chelation, antioxidants, and modulation of the HO-1 pathway hold promise for restoring neutrophil function. A deeper understanding of these mechanisms may guide the development of new interventions to reduce infectious complications and improve patient outcomes.

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기사명 저자명 페이지 원문 목차
Molecular spectrum and carrier frequency of deletional hereditary persistence of fetal hemoglobin and delta-beta thalassemia in Malaysia Faidatul Syazlin Abdul Hamid, Sabariah Md Noor, Mei I Lai, Samsol Kamal Mohd Bahari, Ezalia Esa, Ermi Neiza Mohd Sahid, Norafiza Mohd Yasin, Yuslina Mat Yusoff p. 1-8
Novel agents and evolving strategies for anemia management in lower-risk myelodysplastic syndromes Junshik Hong p. 1-7
Treatment of transplant-ineligible multiple myeloma Jongheon Jung p. 1-7
Tandem autologous stem cell transplant in multiple myeloma patients with minimal residual disease : an explorative study Sieun Oh, Sung-Soo Park, Jung Yeon Lee, Jae-Ho Yoon, Sung-Eun Lee, Hee-Je Kim, Seung-Hwan Shin, Young-Woo Jeon, Seung-Ah Yahng, Jin Jung, Ari Ahn, Myungshin Kim, Chang-Ki Min p. 1-10
Aggressive natural killer cell leukemia therapy in the L-asparaginase era : why are we failing? Sang Eun Yoon, Junhun Cho, Hyun-Young Kim, Seok Jin Kim, Won Seog Kim p. 1-13
Unveiling the role of microRNAs, the PI3K/AKT pathway, and their associations in various types of leukemia : a comprehensive review Amir Modarresi Chahardehi, Esfandiar Mali, Arya Afrooghe, Amirmasoud Asadi, Amirreza Khalaji, Hamed Soleimani Samarkhazan, Hananeh Esmaeil Beygi, Amirhossein Mohagheghi, Maryam Khanbabaei, Heliya Haghani, Reza Arefnezhad, Fatemeh RezaeiTazangi p. 1-13
Early CD4 + T cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou p. 1-10
Beyond anemia : unraveling neutrophil defects and infection susceptibility in β-Thalassemia Chingiz Asadov, Gunay Aliyeva p. 1-10
(Correspondence) Durable responses and favorable cost-effectiveness of rituximab‑based chemoimmunotherapy for primary cold agglutinin disease Kenichi Ito, Tomoko Kitagawa, Saya Motohashi, Kazuhiko Hirano, Naohiro Sekiguchi p. 1-6
(Correspondence) Current immunotherapeutic approaches for relapsed/refractory follicular lymphoma : bispecific antibodies and CAR T-Cell therapies So Yeon Park, Gi-June Min p. 1-6
(A) comparative study of hematologic response to ropeginterferon alfa-2b in hydroxyurea-resistant or intolerant polycythemia vera : a real-world data-based analysis Sung-Eun Lee, Seug Yun Yoon, Sung-Yong Kim, Soo-Mee Bang, Insoo Lee, Jihyuk Lee, Junshik Hong p. 1-7
Plasma interleukin : 12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia Wadhera Sarthak, Jain Arihant, Sahni Aarushi, Swain Rudra Narayan, Singh Charanpreet, Jandial Aditya, Aggarwal Ritu, Hans Rekha, Prakash Gaurav, Khadwal Alka, Grover Sandeep, Das Reena, Malhotra Pankaj p. 63-63
Brentuximab vedotin combined with cisplatin, cytarabine, and dexamethasone treatment in transplant : eligible Korean patients with relapsed or refractory Hodgkin’s lymphoma Yi Jun Ho, Park Young Hoon, Lee Myung-won, Yoo Kwai Han, Hong Junshik, Eom Hyeon-Seok p. 62-62
Insights into Treatment : Free Remission (TFR) outcomes in Chronic Myeloid Leukaemia (CML) – a tertiary centre experience in Malaysia Liam Christopher Chin Keong, Boo Yang Liang, Lim Li Min, Chong Siew Lian, Sharif Azizan, Wong Yih Seong, Selvaratnam Veena, Tan Sen Mui, Lim Soo Min p. 64-64
Invasive fungal infections in hematologic diseases : evidence, challenges, and clinical practice Cho Sung-Yeon, Lee Chae Eun, Nho Dukhee, Lee Dong-Gun p. 65-65
Measurable residual disease monitoring after hematopoietic stem cell transplantation Shin Saeam p. 66-66
Translational investigation of tolinapant (ASTX660) in acute myeloid leukemia by integrating clinical, bioinformatic and pharmacological approaches Lima Keli, Nogueira Frederico Lisboa, Reis-Silva Catarina Sofia Mateus, de Cássia Cavaglieri Rita, Costa-Lotufo Leticia Veras, Machado-Neto João Agostinho, Rego Eduardo Magalhães p. 67-67

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