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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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초록보기

Sarcopenia starts around age 40, with individuals losing more than 30% of muscle mass by age 70. Due to the absence of approved pharmacological treatments, current management primarily relies on exercise and protein supplementations.

Schizonepeta tenuifolia

is a medicinal plant commonly found in Korea, China, Japan and is traditionally used for headaches, colds and allergies. However, its preventive effect against sarcopenia have not yet been explored. This study to investigate whether the ethanol extract of

Schizonepeta tenuifolia

(DKB138) enhances muscle strength in a dexamethasone (DEX)-muscle atrophy mice model. The preventive effects of DKB138 against muscle atrophy were evaluated in DEX-induced models both in vitro and in vivo. In vitro, DEX-induced myotubes were assessed for cell viability to determine cytoprotective effects. In vivo, a DEX-induced muscle atrophy mouse model was used evaluate muscle strength and functional performance. Using UPLC and comparison with reference standards, seven components of DKB138 were identified. DKB138 effectively prevented DEX-induced death in C2C12 skeletal muscle cells. In vivo, mice treated with DKB138 exhibited 28.5% increase in grip strength (***

p

 < 0.001) and a threefold significant increase in running distance (**

p

 < 0.01) compared to the DEX-induced mice. Additionally, DKB138 treatment resulted in downregulation of Murf-1 and Atrogin mRNA while upregulating of MyoD mRNA expression. These finding demonstrate that DKB138 protects against DEX-induced muscle atrophy by suppressing muscle degradation factors and enhancing muscle strength. These results suggest that DKB138 has potential as functional food against muscle dysfunction and atrophy.

Graphical Abstract

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Salvianolic Acid B Prevents Bone Loss in Prednisone-Treated Rats through Stimulation of Osteogenesis and Bone Marrow Angiogenesis 미소장
2 Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome 미소장
3 Atrogin-1, MuRF-1, and sarcopenia 미소장
4 Dexamethasone-induced skeletal muscle atrophy was associated with upregulation of myostatin promoter activity 미소장
5 Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy 미소장
6 Validation of Edible Taste Strips for Assessing PROP Taste Perception 미소장
7 Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise 미소장
8 Morphology of glandular trichomes of Japanese catnip ( Schizonepeta tenuifolia Briquet) and developmental dynamics of their secretory activity 미소장
9 Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification 미소장
10 Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway 미소장
11 Master control: transcriptional regulation of mammalian Myod 미소장
12 Chondroprotective Effect of Cynaroside in IL-1β-Induced Primary Rat Chondrocytes and Organ Explants via NF-κB and MAPK Signaling Inhibition 미소장
13 Effect of Jakyakgamcho-Tang Extracts on H2O2-Induced C2C12 Myoblasts 미소장
14 Mechanisms of muscle atrophy and hypertrophy: implications in health and disease 미소장
15 Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes 미소장
16 Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis 미소장
17 Review on Chemical Constituents of Schizonepeta tenuifolia Briq. and Their Pharmacological Effects 미소장
18 Inflammation: Roles in Skeletal Muscle Atrophy 미소장
19 Salvia plebeia R.Br. and Rosmarinic Acid Attenuate Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes 미소장
20 Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice 미소장
21 Linoleic Acid Induced Changes in SZ95 Sebocytes—Comparison with Palmitic Acid and Arachidonic Acid 미소장
22 Hesperidin Ameliorates Sarcopenia through the Regulation of Inflammaging and the AKT/mTOR/FoxO3a Signaling Pathway in 22–26-Month-Old Mice 미소장
23 Ubiquitin-proteasome pathway in skeletal muscle atrophy 미소장
24 Biomarkers of Hepatic Toxicity: An Overview 미소장
25 Luteolin alleviates muscle atrophy, mitochondrial dysfunction and abnormal FNDC5 expression in high fat diet-induced obese rats and palmitic acid-treated C2C12 myotubes 미소장

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