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Streptococcus mutans

mediates enamel demineralization through acid production via glycolysis, while

Streptococcus salivarius

, as a commensal bacterium, promotes caries progression by enhancing biofilm formation. Their synergistic interaction amplifies cariogenicity. Therefore, developing strategies to inhibit both bacterial species is imperative. This study investigated the extraction and characterization of a polysaccharide from mangosteen scarfskin (MSP) and its antimicrobial potential against cariogenic bacteria. Using ultrasonic-assisted extraction, MSP was obtained with a yield of (9.93 ± 0.5696)%, presenting light brown coloration. Antimicrobial assays demonstrated strong anti-efficacy activity against

Streptococcus mutans

and

Streptococcus salivarius

, showing a MIC of 1 mg/mL and significant bactericidal effects at 1×MIC and 2×MIC concentrations. Biofilm metabolism analysis showed that MSP caused dose-dependent suppression of bacterial metabolism, while its inhibitory effect on EPS production increased proportionally with concentration. Molecular docking identified specific hydrogen-bond interactions between arabinose (the primary component of MSP) and key residues (THR-315, SER-10, and SER-247) of glucosyltransferase-C (GTF-C), while molecular dynamics simulations demonstrated that arabinose disrupted the structural stability of GTF-C. These findings collectively suggest MSP’s promising application as a novel food additive for caries prevention through oral

streptococcal

control.

Graphical abstract

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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참고문헌 (37건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Insights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation 미소장
2 Oral switch versus standard intravenous antibiotic therapy in left-sided endocarditis due to susceptible staphylococci, streptococci or enterococci (RODEO): a protocol for two open-label randomised controlled trials 미소장
3 Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions 미소장
4 Activity of quercetin and kaemferol against Streptococcus mutans biofilm 미소장
5 Exopolysaccharides Produced by Streptococcus mutans Glucosyltransferases Modulate the Establishment of Microcolonies within Multispecies Biofilms 미소장
6 Oral Biofilm Architecture on Natural Teeth 미소장
7 Gartanin as an Isoprenylated Xanthone from Mangosteen ( Garcinia mangostana L .): Insights into Its Synthesis, Extraction, Determination, and Bioactivity 미소장
8 The origin of cultivated mangosteen ( Garcinia mangostana L. var. mangostana ): Critical assessments and an evolutionary‐ecological perspective 미소장
9 Improving preservation of bioactive compounds in mangosteen peel flour through pre-treatment with bleaching, ethanol, and vacuum pulse 미소장
10 Ultrasonic-assisted extraction, analysis and properties of purple mangosteen scarfskin polysaccharide and its acetylated derivative 미소장
11 Recent evidence on prominent anti-bacterial capacities of compounds derived from the mangosteen fruit 미소장
12 Biomolecules of Fermented Tropical Fruits and Fermenting Microbes as Regulators of Human Hair Loss, Hair Quality, and Scalp Microbiota 미소장
13 Antimicrobial Efficacy of Mangosteen (Garcinia mangostana) Peel Extracts in Airborne Microbial Control within Livestock Farming Environments 미소장
14 Preparation and Analysis of Pueraria lobata Polysaccharides 미소장
15 Composition and antioxidant activity of polysaccharides from jujuba by classical and ultrasound extraction 미소장
16 Synergistic effects of colistin–rifampin-based triple antimicrobial combination therapy against Carbapenem-resistant Pseudomonas aeruginosa: a time-kill assay 미소장
17 pH-FISH: coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples 미소장
18 Statistical Optimization of Exopolysaccharide and Biomass Production by Mangrove Fungi Fusarium equiseti ANP2 and its Potential Application as Bioemulsifier and Chelator 미소장
19 Potential effects of Psidium sp., Mangifera sp., Mentha sp. and its mixture (PEM) in reducing bacterial populations in biofilms, adherence and acid production of S. sanguinis and S. mutans 미소장
20 PubChem Substance and Compound databases 미소장
21 AutoDockFR: Advances in Protein-Ligand Docking with Explicitly Specified Binding Site Flexibility 미소장
22 Application of the molecular dynamics simulation GROMACS in food science 미소장
23 Additive CHARMM36 Force Field for Nonstandard Amino Acids 미소장
24 A CGenFF‐based force field for simulations of peptoids with both cis and trans peptide bonds 미소장
25 Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind 미소장
26 Structural and functional benefits of Ganoderma lucidum polysaccharides due to space mutagenesis 미소장
27 Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver 미소장
28 Characterization of Nanohybridosomes from Lipids and Spruce Homogenate Containing Extracellular Vesicles 미소장
29 Novel films of pectin extracted from ambarella fruit peel and jackfruit seed slimy sheath: Effect of ionic crosslinking on the properties of pectin film 미소장
30 Microbial response to acid stress: mechanisms and applications 미소장
31 Resistance Mechanisms to Antimicrobial Peptides in Gram-Positive Bacteria 미소장
32 Targeting glucosyltransferases to combat dental caries: Current perspectives and future prospects 미소장
33 Effect of Rubusoside, a Natural Sucrose Substitute, on Streptococcus mutans Biofilm Cariogenic Potential and Virulence Gene Expression In Vitro 미소장
34 Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans 미소장
35 Hydrogen bonds vs RMSD: Geometric reaction coordinates for protein folding 미소장
36 Conformational difference between two subunits in flavin mononucleotide binding protein dimers from Desulfovibrio vulgaris (MF): molecular dynamics simulation 미소장
37 Step‐Growth Polymerized Systems of type “A3 + A1”: a Method to Calculate the Bivariate (Molecular size) × (Square Radius of Gyration) Number Distribution 미소장