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Collagenases (MMP-1, MMP-8, and MMP-13) play significant roles in the pathophysiology of osteoarthritis. Among these proteins, MMP-13 and MMP-8 are known for their catabolic roles in the degradation of the articular cartilage matrix. Using computational studies, we had previously observed that a metabolite of curcumin, Curcumin monoglucuronide (CMG), binds to MMPs involved in cartilage matrix destruction. The purpose of this study was to confirm the ability of CMG to protect cartilage by blocking the activity of these enzymes. The ability of CMG to bind and block the activities of MMP-13 and MMP-8 was established using several physicochemical methods. First, the protective effect of CMG on MMP-mediated cartilage destruction was demonstrated using cartilage explants in vitro. Second, the in vivo efficacy of CMG was tested by comparison with BI-4394, a specific MMP-13 inhibitor, using a rat anterior cruciate ligament transection (ACLT) model. These studies demonstrated that CMG was more effective than BI-4394 at preventing cartilage degeneration. In separate in vitro studies, CMG did not affect chondrocyte proliferation or the expression of NF-κB-mediated proinflammatory genes. Together, these findings demonstrate the therapeutic potential of CMG and emphasize the importance of inhibiting both MMP-13 and MMP-8 to achieve improved clinical outcomes.

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기사명 저자명 페이지 원문 목차
Targeting NF-κB in diabetic nephropathy : exploring the therapeutic potential of phytoconstituents Beena Levakumar Abhirami, Anithakumari Aswathy Krishna, Alaganandam Kumaran, Chun-Hui Chiu p. 577-637
Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications Anis Najwa Abdul Rani, Anand Gaurav, Vannajan Sanghiran Lee, Nadiah Mad Nasir, Sharifuddin Md Zain, Vaishali M. Patil, Ming Tatt Lee p. 638-675
NRF2 activation in cancer and overview of NRF2 small molecule inhibitors Hoang Hai Ngo, Bo-Yeong Yu, Jeong-Eun Lee, Hyunwoo Kim, Young-Sam Keum p. 676-705
Enhancer regulation in cancer : from epigenetics to m6A RNA modification Arathy Vasukutty, Poshan Yugal Bhattarai, Hong Seok Choi p. 706-735
9H-carbazole derivatives from a Streptomyces species under potassium iodide stress and their anti-inflammatory properties Pengcheng Yan, Yunlong Liu, Jibin Liu, Linmeng Chen, Ning Li, Weiming Zhu p. 736-744
(A) novel multi-target compound mitigates amyloid plaques, synaptic deficits, and neuroinflammation in Alzheimer’s disease models Yeongyeong Lee, Sukmin Han, Jeongmi Lee, Yongeun Cho, Jun-Sik Kim, Yeji Jeon, Heewon Cho, Heejin Yoo, Yujung Byun, Tai Kyoung Kim ... [et al.] p. 745-764
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13 Himadri Shekhar Roy, Chirag Kulkarni, K.M. Neethu, Anand Babu, Malika Arora, Govindasamy Jayamurugan, Dipankar Mandal, Rajdeep Guha, Naibedya Chattopadhyay, Deepa Ghosh p. 765-781
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis Xule Yang, Yunge Lou, Huan Li, Yuanyuan Ma, Zihan Wang, Jiye Aa, Guangji Wang, Yuan Xie p. 782-797
Sphingolipid modulation and anti-tumor activity of Jaspine B in HepG2 bearing mice Jihoon Lee, Ji-Hyeon Jeon, Minyeong Pang, Min-Koo Choi, Dongjoo Lee, Im-Sook Song p. 798-813
Neuroprotective effects of taurine in a rodent model of Parkinson’s disease involve modulating astrocyte-mediated inflammation Sung Min Moon, Jaehoon Kim, Jaeheon Seol, Seonguk Yang, Duwon Jung, Chang Yup Kim, Chang Seok Kim, Ki Wung Chung, Young-Suk Jung, Seung-Cheol Chang, Hae Young Chung, Jaewon Lee p. 814-829

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