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With a rapidly aging population and increasing use of antiresorptive agents, medication-related osteonecrosis of the jaw (MRONJ) represents a growing clinical challenge worldwide. To address the need for tailored clinical guidance, a multidisciplinary task force was convened. Five Korean academic societies—the Korean Society for Bone and Mineral Research, the Korean Association of Oral and Maxillofacial Surgeons, the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons, the Korean Society of Osteoporosis, and the Korean Endocrine Society—collaborated to develop this position statement. The consensus was formulated through comprehensive reviews of literature, combined with three rounds of formal surveys to consolidate expert opinion on controversial topics. This position paper provides evidence-based clinical guidelines for the prevention, diagnosis, and management of MRONJ tailored to the Korean healthcare environment. The diagnostic criteria affirm the standard definition but add a provision for diagnosis based on clinical or radiographic evidence of necrotic bone, even if the traditional 8-week timeframe has not been met. The committee advocates for retaining Stage 0 in the staging system to emphasize early detection and preventive intervention. Key recommendations include prescriptive, drug-specific guidelines for prophylactic drug holidays (e.g., a 2-month pause for oral bisphosphonates; timing surgery 3-4 months after the last denosumab injection) to minimize MRONJ risk from dental procedures. This statement also provides a clear framework for therapeutic drug holidays in established MRONJ, carefully balancing the need for jaw healing against systemic fracture risk. For treatment, this statement advocates for early and active surgical intervention across all MRONJ stages, supported by evidence of superior long-term outcomes compared to conservative management.

This position statement offers a unique, evidence-based Korean clinical practice guideline for managing MRONJ. It is intended to standardize care, reduce clinical confusion, and ultimately improve patient outcomes by providing a clear framework for decision-making.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Medication-related osteonecrosis of the jaw : an evidence-based 2025 position statement from a Korean multidisciplinary task force Jin-Woo Kim, Sung-Hye Kong, Jae-Young Kim, Mi Kyung Kwak, Jun-Young Kim, Ji-Hyeon Oh, Hyung-Youl Park, BeomTaek Kim, Young-Kyun Lee, Jeong Joon Han ... [et al.] p. 333-353

Prolotherapy for temporomandibular joint disorders : an updated comprehensive review Yesel Kim, Min-Joong Kim, Pil-Young Yun, Jeong-Kui Ku p. 354-361

(A) three-year retrospective study of pediatric and adolescent oral and maxillofacial trauma and infections at emergency department in a tertiary care medical hospital Changwoo Park, Hyeonjin Kim, Junghwan Bae, Jihye Ryu, Chiho Moon, Na-Rae Choi, Jae-Min Song, Jae-Yeol Lee, Dae-Seok Hwang, Yong-Deok Kim, Sang-Hun Shin, Uk-Kyu Kim p. 362-368

Evaluating the antimicrobial efficacy, growth factor release drug kinetics of titanium platelet-rich fibrin loaded with amoxiclav, metronidazole and neem gel : an in vitro study Shiva Shankar Gummaluri, Trinath Kishore Damera, Viswa Chandra Rampalli, Ramanarayana Boyapati, Kaarthikeyan Gurumoorthy p. 369-383

Applications of leukocyte platelet-rich fibrin in oral and maxillofacial surgery : case series Déborah Rocha Seixas, Isadora Molina Sanches, Alessandra Mazzo, Paulo Sergio da Silva Santos, Eduardo Sanches Gonçales p. 384-396

Functional outcomes of total temporomandibular joint replacement with customized prostheses : a clinical case series Gonzalo Martinovic Guzmán, Josefina Silva Radnic, Sofía Escobar Riquelme, Juan Pablo Salinas Cazenave, Paola Lillo Gómez, Jaime Mayorga Maldonado, Carlos Plaza Álvarez, Karen Danke Hausdorf p. 397-403

Advantages of the upper eyelid approach with lateral canthotomy in the resolution of complex fronto-orbito-zygomatic fractures : bibliographic review of conventional approaches and a case report Pedro Tapia, Fernanda Díaz, Jessica Zeballos, Sofía Díaz, Florencia Jollán, Benjamín Ossandón-Zúñiga p. 404-409

Tunneling of facial approaches for resection and reconstruction of benign mandibular lesions : a report of two cases Pedro Tapia, Christopher Reyes, Jessica Zeballos, Micaela Schälchli, Benjamín Ossandón-Zúñiga, María-José Flores, Camilo Barrientos, Enrique Steffens p. 410-416

Two-stage mandibular setback employing modified Dingman’s mandibular body osteotomy with step for large antero-posterior dentofacial deformity correction : a report of two cases Nithish Sankepally, Mrunalini Ramanathan, Masako Fujioka-Kobayashi, Rie Sonoyama-Osako, Elavenil Panneerselvam, Takahiro Kanno p. 417-425

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