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Background: The survival impact of bisphosphonates (BPs) remains uncertain, particularly in East Asian populations, where new-user analyses have been limited. Methods: This was a retrospective, new-user cohort study using the Korean National Health Insurance Service–National Sample Cohort (2002–2011). We identified new users of BPs (N=41,854), and a 1:1 age-matched control group (N=41,854) among women aged ≥ 50 years. Participants were followed for all-cause mortality for up to 10 years. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs), adjusting for age and the Charlson Comorbidity Index. Results: A total of 83,708 women were included. Compared with the control group, the risk of all-cause mortality was lower in BP group. BP users showed adjusted HR of 0.47 (95% confidence interval, 0.44–0.49; P<0.001) compared to controls. Conclusions: In this large, nationwide Korean cohort, initiating BPs was associated with a reduced risk of all-cause mortality in women aged 50 and older. These findings suggest that BPs may have survival benefits beyond fracture prevention.

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Endocrine regulation of osteoporosis : insights from the brain-bone axis theory Xin Chen, Jialing Wang, Tingting Deng, Qing Ni, Fanjie Liu p. 247-262
Emerging role of myostatin inhibitors in the management of glucagon-like peptide-1-associated sarcopenia and metabolic disorders Jongmin Baik, Yun-Sil Lee p. 263-275
Myostatin function during in vitro myogenesis : considerations for knockout-based mechanistic analysis Joonho Suh, Jongmin Baik, Yun-Sil Lee p. 276-284
Nano calcium from marine fish bones via high-energy ball milling : a potential natural supplement for bone health Devy N.A. Hasanuddin, Safira Prisya Dewi, Sri Fatmawati, Annis Catur Adi, Heni Rachmawati p. 285-296
Association between diet quality and knee osteoarthritis : insights from the Korea National Health and Nutrition Examination Survey 2013 Hyunmi Han, Clara Yongjoo Park p. 297-305
Determinants of bone mineral density in postmenopausal women : the role of lean and fat mass by dual energy X-ray absorptiometry assessment Luis A. Ramírez Stieben, Lucas R. Brun, Silvana Di Gregorio, Luis Miguel Del Río Barquero, María Lorena Brance p. 306-314
Challenges in evaluation and management in tumor-induced osteomalacia : a retrospective institutional and literature-based scoping review in Korean patients Seyoun Park, Sung Joon Cho, Jin Ah Park, Namki Hong, Yumie Rhee p. 315-322
Bisphosphonate use and reduced all-cause mortality in Korean women older than 50 years : a nationwide sample cohort study Soon Young Park, Jisoo Lee, Youjin Lee, Jung-Wee Park, Young-Kyun Lee p. 323-330
Impact of bone graft type on spinal fusion outcomes in adolescent idiopathic scoliosis : updated meta-analysis Eunseo Joung, Ki-Tae Park, Naye Kang, Suyeon Park, Nah Yon Kim, Young Hak Roh, Byung-Ho Yoon p. 331-343

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