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Patients with acute leukemia, particularly those undergoing allogeneic hematopoietic stem cell transplantation, are at a high risk of contracting invasive fungal infections (IFIs). These IFIs substantially increase morbidity and mortality.

Over the past decade, the paradigm of IFI management has shifted markedly, with an increased emphasis on prevention and treatment. Expanded use of antifungal agents and advances in novel therapies have prolonged survival in patients with hematologic malignancies. This progress also allows subsequent lines of chemotherapy to be administered while maintaining antifungal therapy once IFIs are controlled. However, these shifts have introduced new challenges, including a rising incidence of breakthrough infections despite prophylaxis, the emergence of infections caused by rare fungi, and growing concerns regarding azole resistance. Although Aspergillus species remain the predominant pathogens, infections by uncommon molds and yeasts are increasingly encountered. This phenomenon complicates the diagnosis and necessitates diagnostic tools beyond galactomannan testing alone. Integration of novel biomarkers and antifungal susceptibility testing is essential for timely and accurate diagnosis. Current guidelines provide relatively well-defined recommendations for the definitive management of invasive aspergillosis, candidiasis, and mucormycosis.

Individualized care and multidisciplinary collaboration are essential to optimize patient outcomes. In addition to prevention, diagnosis, and treatment, a deeper understanding of host immunity and its interactions with IFIs is critical for improving patient outcomes and guiding the next generation of management strategies.

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Novel agents and evolving strategies for anemia management in lower-risk myelodysplastic syndromes Junshik Hong p. 1-7
Treatment of transplant-ineligible multiple myeloma Jongheon Jung p. 1-7
Tandem autologous stem cell transplant in multiple myeloma patients with minimal residual disease : an explorative study Sieun Oh, Sung-Soo Park, Jung Yeon Lee, Jae-Ho Yoon, Sung-Eun Lee, Hee-Je Kim, Seung-Hwan Shin, Young-Woo Jeon, Seung-Ah Yahng, Jin Jung, Ari Ahn, Myungshin Kim, Chang-Ki Min p. 1-10
Aggressive natural killer cell leukemia therapy in the L-asparaginase era : why are we failing? Sang Eun Yoon, Junhun Cho, Hyun-Young Kim, Seok Jin Kim, Won Seog Kim p. 1-13
Unveiling the role of microRNAs, the PI3K/AKT pathway, and their associations in various types of leukemia : a comprehensive review Amir Modarresi Chahardehi, Esfandiar Mali, Arya Afrooghe, Amirmasoud Asadi, Amirreza Khalaji, Hamed Soleimani Samarkhazan, Hananeh Esmaeil Beygi, Amirhossein Mohagheghi, Maryam Khanbabaei, Heliya Haghani, Reza Arefnezhad, Fatemeh Rezaei-Tazangi p. 1-13
Early CD4 + T cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou p. 1-10
Beyond anemia : unraveling neutrophil defects and infection susceptibility in β-Thalassemia Chingiz Asadov, Gunay Aliyeva p. 1-10
(Correspondence) Durable responses and favorable cost-effectiveness of rituximab‑based chemoimmunotherapy for primary cold agglutinin disease Kenichi Ito, Tomoko Kitagawa, Saya Motohashi, Kazuhiko Hirano, Naohiro Sekiguchi p. 1-6
(Correspondence) Current immunotherapeutic approaches for relapsed/refractory follicular lymphoma : bispecific antibodies and CAR T-Cell therapies So Yeon Park, Gi-June Min p. 1-6
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Plasma interleukin‑12 levels as a potential biomarker of fatigue and quality of life in patients with primary immune thrombocytopenia Sarthak Wadhera, Arihant Jain, Aarushi Sahni, Rudra Narayan Swain, Charanpreet Singh, Aditya Jandial, Ritu Aggarwal, Rekha Hans, Gaurav Prakash, Alka Khadwal, Sandeep Grover, Reena Das, Pankaj Malhotra p. 1-8
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Invasive fungal infections in hematologic diseases : evidence, challenges, and clinical practice SungYeon Cho, Chae Eun Lee, Dukhee Nho, DongGun Lee p. 1-7
(Correspondence) Measurable residual disease monitoring after hematopoietic stem cell transplantation Saeam Shin p. 1-3
(Correspondence) Translational investigation of tolinapant (ASTX660) in acute myeloid leukemia by integrating clinical, bioinformatic and pharmacological approaches Keli Lima, Frederico Lisboa Nogueira, Catarina Sofia Mateus Reis‑Silva, Rita de Cássia Cavaglieri, Leticia Veras Costa‑Lotufo, João Agostinho Machado‑Neto, Eduardo Magalhães Rego p. 1-5

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