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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Early pregnancy bleeding and recurrent miscarriage are common obstetric challenges associated with significant maternal anxiety and adverse pregnancy outcomes. Progesterone plays a central role in implantation, immune tolerance, and maintenance of early pregnancy. Recent large-scale randomized trials, including Progesterone in Recurrent Miscarriages and Progesterone in Spontaneous Miscarriage, have clarified the clinical utility of vaginal micronized progesterone in specific patient populations. This review summarizes the physiological role of progesterone, pharmacologic characteristics of vaginal micronized progesterone, and current evidence regarding its use in threatened and recurrent miscarriage, with emphasis on recent randomized trials and guideline recommendations.

A narrative review was conducted based on major clinical trials, meta-analyses, and international guidelines including National Institute for Health and Care Excellence, Cochrane, and recent Lancet publications. Vaginal micronized progesterone does not improve live birth rates in women with unexplained recurrent miscarriage alone. However, in women with early pregnancy bleeding and a history of one or more previous miscarriages, progesterone significantly increases live birth rates.

Safety data demonstrate no increased risk of congenital anomalies or neonatal complications.Vaginal micronized progesterone is recommended for women with early pregnancy bleeding and at least one prior miscarriage. Evidence supports its safety and clinical benefit in this subgroup. Further welldesigned trials are needed to refine optimal dosing and treatment duration.

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기사명 저자명 페이지 원문 목차
Factors affecting neonatal intensive care unit length of stay in preterm infants receiving dysphagia rehabilitation therapy : a retrospective study Kyung Nam Kim, Cheong Jun Moon, Bo Young Hong, Jung Hyun Lee p. 97-106
Kabuki syndrome presenting with congenital hyperinsulinemic hypoglycemia : the first neonatal case reports in Korea Eun Yeong Chang, Misun Yang, So Yoon Ahn, Se In Sung, Yun Sil Chang, Ja-Hyun Jang, Hyung-Doo Park p. 107-111
Clinical application of vaginal micronized progesterone for prevention of miscarriage : a recent comprehensive review Iseul Kim, Sujin Bae, Hyeju Han, Sunghun Na p. 91-96
Nephrotoxicity due to acyclovir in chickenpox (varicella) with pregnant woman : a case report Hyeju Han, Iseul Kim, Sujin Bae, Heejoo Hong, M Sejin Lee, Sunghun Na p. 112-114

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