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AbstractAim The aim of the present study was to evaluate condylar volume and mandibular ramus in patients undergoingorthognathic surgery.

Method Relevant keywords were searched in the international databases Cochrane, Embase, and MEDLINEup to February 2025. Study selection criteria were based on the PICOS strategy; randomized clinical trial studies,cohort studies, cross-sectional studies, case–control studies (study (S)) that examined changes in condylar and ramusposition (Outcome (O)) in orthognathic surgery as skeletal treatment (Intervention (I)) for Class III versus Class II(Comparison (C)) in patients who had undergone orthognathic surgery (Population (P)). Data were collected basedon study findings from three-dimensional (3D) cephalometric/cone-beam computed tomographic (CBCT)analysisand measurements of condylar angle, volume, and position. The methodological index for non-randomized studies(MINORS) used to determine the quality of the studies. Mean differences were used as an effect size with fixed-effectsmodel and inverse-variance methods of 95% confidence intervals (CI). Meta-analysis was performed using Stata (asof version 17).

Result The mean differences in condylar height between Class II and Class III were 2.19 mm (MD 2.19 mm 95% CI;1.32 mm, 3.96 mm; p < 0.05). The mean differences in ramus angle between Class II and Class III were − 0.02° (MD − 0.0295% CI − 0.06, 0.03; p > 0.05).

Conclusion Based on the meta-analysis of the present study, orthognathic surgery did not significantly affectthe microstructure of the mandibular ramus in the correction of class III malocclusions. In Class II, the condyle heightwas significantly reduced after orthognathic surgery, while the condyle width did not change.

Trial registration PROSPERO CRD420251054773.

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