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Purpose: This study aimed to evaluate the efficacy and safety of ginseng berry extract (GBE) (SIRTBERRYTM) in treating andropause symptoms in aging men.

Materials and Methods: In this randomized, double-blind, placebo-controlled trial, 116 men with andropause symptoms were assigned to receive either 700 mg/day GBE or placebo for 8 weeks. The primary efficacy variables included changes in the aging male symptoms (AMS) scale and improvement rate as per the androgen deficiency in aging male (ADAM) questionnaire, from the baseline. Secondary efficacy measurements included changes in the total and free testosterone levels, serum lipid levels, International Index of Erectile Function (IIEF) scores, International Prostate Symptom Score (IPSS), and various hormonal and metabolic markers.

Results: The GBE group exhibited significant improvements in AMS scores, ADAM improvement rates, and IIEF scores compared to the placebo group. Specifically, the GBE group showed a 70% improvement in ADAM scores versus a 47.83% improvement in the placebo group (p=0.0376), and a greater reduction in AMS scores (p=0.0205). Significant enhancements were observed in erectile function, with the IIEF scores improved more in the GBE group (p=0.0334), particularly in the erectile function domain (p=0.0290). No serious adverse event was reported, and the safety profile of GBE was found to be comparable to that of placebo.

Conclusions: GBE significantly improved andropause symptoms, including sexual function, and demonstrated a favorable safety profile, suggesting its potential as a safe and effective alternative treatment for testosterone deficiency syndrome. Further research regarding its long-term benefits and applicability to broader populations is warranted.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
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Testosterone replacement therapy in hypogonadal men with a prostate cancer diagnosis : a British Society for Sexual Medicine consensus statement Marie Alexandra Edison, Michael Kirby, Geoffrey Ian Hackett p. 5-22
Clinical effects and safety outcomes of platelet-rich plasma therapy in patients with vasculogenic erectile dysfunction : a systematic review and meta-analysis Marco Falcone, Mirko Preto, Hakan Keskin, Jesus Fernando Solorzano Vazquez, Ravi Banthia, Tara Mahendran, Muslim Dogan Deger, Vinod K.V., Rosadi Putra, Tamilselvi Sethupathy ... [et al.] p. 23-35
Nocturia, sleep quality, and mortality : a systematic review and meta-analysis Alvin Christopher Lavadia, Jae Heon Kim, Seong Woo Yun, Tae Il Noh p. 36-48
Efficacy and tolerability outcomes of minimally invasive surgical treatments for benign prostatic hyperplasia : a random-effects network meta-analysis Brian Ng Hung Shin, Rebekah Maksoud, Samuel Tan, Handoo Rhee, Hyun Jun Park, Eric Chung p. 49-63
Global Andrology Forum (GAF) clinical guidelines on the management of infertile men with varicocele Selahittin Çayan, Germar-M. Pinggera, Widi Atmoko, Taha Hamoda, Rupin Shah, Armand Zini, Eric Chung, Giovanni Maria Colpi, Amarnath Rambhatla, Hiva Alipour ... [et al.] p. 64-77
Global andrology forum clinical guidelines on the relevance of sperm DNA fragmentation in reproductive medicine Selahittin Çayan, Ala'a Farkouh, Ashok Agarwal, Widi Atmoko, Christine Wyns, Mohamed Arafa, Armand Zini, Rupin Shah, Hiva Alipour, Eric Chung ... [et al.] p. 78-89
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Single-cell analysis combined with Mendelian randomization identifies genes associated with prostate cancer cells Weizhuo Wang, Kaiyu Lu, Xi Zhang, Kai Wei, Gang Cheng, Zheng Tang, Mingwei Zhan, Caibin Fan, Xu Fu p. 136-149
Robot-assisted versus open radical prostatectomy in the treatment of localized prostate cancer : 3-year results from a prospective cohort study Chang Wook Jeong, Sang Hyun Yoo, Jang Hee Han, Seung-hwan Jeong, Hyeong Dong Yuk, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak p. 150-160
Does the quality and readability of information related to varicocele obtained from ChatGPT 4.0 remain consistent across different models of inquiry? Zhao Luo, Sung Chul Kam, Ji Yong Kim, Wenhao Hu, Chuan Lin, Hyun Jun Park, Yu Seob Shin p. 161-170
Trends in medical traveling for radical prostatectomy in the era of robotic surgery : a nationwide cohort study in Korea Jinhyung Jeon, Jee Soo Ha, Hye Sun Lee, Soyoung Jeon, Jae Heon Kim, Kang Su Cho p. 171-181
Efficacy and safety of ginseng berry extract (SIRTBERRY™) in treating andropause symptoms : a randomized, double-blind, placebo-controlled clinical trial Sun-Young Park, Yong Seong Lee, In Heo, Soon Chul Myung, Sang Jun Lee, Jin Wook Kim p. 182-193
Characteristics of germline and somatic mutations of DNA repair genes in Korean men with prostate cancer Hakmin Lee, Jin-Nyoung Ho, Sang Hun Song, Jong Jin Oh, Jung Sik Huh, Hak-Min Kim, Kwang Hyun Kim, Sunghan Kim, Seok-Soo Byun p. 194-202
Identification of a novel biallelic CFAP119 variant in an infertile man with asthenoteratozoospermia Jun Ma, Tiechao Ruan, Chuan Jiang, Xiang Wang, Yingteng Zhang, Yunchuan Tian, Xinyao Tang, Yihong Yang, Ying Shen p. 203-215

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