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국회도서관 홈으로 정보검색 소장정보 검색

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동의어 포함

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Interferon regulatory factors (IRF) are transcription factors that are crucial in various physiological processes, including cell growth, viral infection, and tumor suppression. Among these, IRF1 is activated by interferon-alpha/beta (IFN-α/β) and interferon-gamma (IFN-γ), and it regulates antiviral gene ex- pression via its DNA-binding domain (DBD). In this study, we identified the IRF1 gene in the seven- band grouper, Hyporthodus septemfasciatus, Hse_IRF1, analyzed its expression level across different tissues, and assessed its antiviral activity. The results showed that the open reading frame of the HHse_IRF1 cDNA was 906 bp long and encoded 301 amino acids. The Hse_IRF1 protein possesses a DNA-binding domain typical of the IRF family, containing six conserved tryptophan residues. Previous studies demonstrates that IRF1 lacking the DBD exhibits weakened intrinsic antiviral activity. Therefore, in this study, we designated the IRF1 variant without the DBD as Hse_dIRF1. In vivo experiments revealed that under normal physiological conditions, Hse_IRF1 transcription was highest in the spleen. Moreover, in fish infected with Nervous Necrosis Virus (NNV), IRF1 expression sig- nificantly increased in the spleen from days 2 to 4 post-infection. Furthermore, in SSN-1 cells, Hse_IRF1 expression reduced viral RNA2 replication by approximately 4.64-fold, while the expressing Hse_dIRF1 resulted in only 2.00-fold decrease compared to the control group. These findings suggest that Hse_IRF1 may play an antiviral role in NNV infection, with the DBD of IRF1 contributing to this process. However, further studies are needed to elucidate its association with other immune-re- lated genes involved in the innate immune response of sevenband grouper.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Parasitic diseases in salmonid aquaculture : a comprehensive review of major threats and management strategies for Korea Jeong-Ho Kim p. 221-244
Systemic hematological and metabolic shifts in grey mullet (Mugil cephalus) during low-grade lymphocystis disease virus (LCDV) infection : insights from viral kinetics, whole blood biochemistry, and PCA Edirimuni Ruwani Kaushalya De Silva, Su-Mi Shin, Myung-Hwa Jung p. 245-259
넙치에서 체중별 VHSV 최소 감염 농도와 환경 요인별 생존능 분석을 통한 수평 전파 위험 평가 = Minimum infectious dose and transmission risk of VHSV in olive flounder (Paralichthys olivaceus) under different body weights and environmental conditions 강효영, 이주엽, 박지연, 허영웅, 이윤항, 노형진, 김재옥, 권문경, 김도형 p. 261-270
불활화 참돔이리도바이러스병(RSIVD) 백신의 효능 평가를 위한 MN50 및 ROC 분석 기반 면역 보호 기준 설정 = Establishment of MN50-based immune protection threshold using ROC analysis for efficacy evaluation of inactivated RSIVD vaccine 김국현, 권우주, 김정한, 민준규, 김광일 p. 271-281
수온 변화가 넙치(Paralichthys olivaceus)의 VHSV 감염성 및 스트레스 반응에 미치는 영향 = Influence of water temperature changes on VHSV infectivity and stress responses in olive flounder (Paralichthys olivaceus) 이주연, 윤수영, 오명주 p. 283-294
전염성조혈기괴사증바이러스(infectious hematopoietic necrosis virus)에 대한 emamectin benzoate의 항바이러스 효과 = Antiviral effect of emamectin benzoate against infectious hematopoietic necrosis virus 이승준, 김한을, 이은섭, 권세련 p. 295-305
Histopathological changes associated with coccidia infection in Pearlscale goldfish (Carassius auratus) = 진주비늘 금붕어(Carassius auratus)에서 콕시디아 감염 시 나타나는 조직병리학적 변화 Su-Bhin Jeong, Min-Young Sohn, Ha-jeong Son, Ji Hye Jin, Gyoungsik Kang p. 307-317
넙치 주요 세균성 병원체 4종의 동시 검출을 위한 Multiplex PCR 기법 개발 = Development of multiplex PCR for detecting four bacterial pathogens in olive flounder (Paralichthys olivaceus) 이주엽, 김윤재, 강효영, 박지연, 허영웅, 이윤항, 김도형 p. 319-327
국내 대서양연어(Salmo salar)에서 분리된 Flavobacterium 균주의 다중유전자 기반 종 동정 = Multigene-based species identification of Flavobacterium strain isolated from domestic Atlantic salmon (Salmo salar) 고성재, 이시윤, 백지우, 신순범, 홍수희 p. 329-341
국내 담수 자연산 어류와 양식 무지개송어에서의 세균성신장병(BKD) 모니터링 = Monitoring of bacterial kidney disease (BKD) in wild freshwater fish and farmed rainbow trout in Korea 김용운, 주민수, 김석렬 p. 343-350
전사체 분석을 통한 Streptococcus parauberis 상시 고발현 프로모터 발굴 및 재조합 단백질 발현 최적화 = Transcriptome-guided identification of novel constitutive promoters in Streptococcus parauberis and their application to recombinant protein expression 박지원, Abdellaoui Najib, 김민선 p. 351-360
넙치(Paralichthys olivaceus)에서 분리된 Vibrio tapetis에 대한 주사 백신의 개발 및 평가 = Development and evaluation of an injectable vaccine against Vibrio tapetis isolated from olive flounder (Paralichthys olivaceus) 김나혜, 김진영, 정성주 p. 361-373
Molecular cloning and characterization of interferon regulatory factor 1 (IRF1) in Sevenband grouper, Hyporthodus septemfasciatus Jaeyoung-Pe, Han-Gyeol Kim, Jeongmin Seo, Myung-Joo Oh, Jong-Oh Kim p. 375-387
Propyl gallate disrupts the intricate network of biofilm formation and quorum sensing in fish pathogens Eun-Seop Lee, Hyeon-Ju Lee, Si-Heon Song, Chae-Min Kim, Eon-Bee Lee p. 389-400
암모니아 노출이 흰다리새우, Litopenaeus vannamei의 혈림프 성분 및 면역반응에 미치는 독성 영향 = Effects of ammonia exposure on survival and physiology of white leg shrimp, Litopenaeus vannamei 임재현, 김수경, 김석렬 p. 401-410
수인성 구리 노출에 따른 넙치, Paralichthys olivaceus의 혈액학적 성상 및 혈장성분의 변화 = Changes in the hematological parameters and plasma components of olive flounder, Paralichthys olivaceus exposed to waterborne copper 이소연, 김민정, 조아현, 강예재, 김준환 p. 411-421
흑마늘 껍질이 무지개송어(Oncorhynchus mykiss)의 성장 및 생리활성에 미치는 영향 = Effects of black garlic peel on the growth and physiological parameters of rainbow trout (Oncorhynchus mykiss) 임새연, 김광혁, 정다현, 박영진 p. 423-433
제주도 건천 주변 연안해역 해수에 대한 미생물학적 오염도 조사 = Microbiological pollution investigation of coastal regions near ephemeral streams in Jeju Island 문영건, 이찬미, 김준환, 허문수 p. 435-445
넙치(Paralichthys olivaceus) 혈청 및 근육에서 세프티오퍼 및 대사체 분석을 위한 HPLC-MS/MS 방법 개발 및 검증 = HPLC-MS/MS method development and validation for ceftiofur and metabolites in serum and muscle of olive flounder (Paralichthys olivaceus) 김가원, 홍주원, 권문경, 서정수 p. 447-456
광주기 조절 및 calcitriol 투여가 무지개송어(Oncorhynchus mykiss)의 포도당 대사와 골 성장에 미치는 영향 = Effects of photoperiod and calcitriol on the glucose metabolism and bone growth in rainbow trout, Oncorhynchus mykiss 박상협, 김정의, 김이경 p. 457-474
CRISPR/dCas9-mediated interference of HIF-1α expression and its effect on VHSV infection in Epithelioma papulosum cyprini cells Min Jun Shin, Eun Gyeong Lee, Ki Hong Kim p. 475-481
봄철 및 가을철에 생산된 넙치 치어의 viral hemorrhagic septicemia virus (VHSV)에 대한 감염성 검토 = Susceptibility of olive flounder (Paralichthys olivaceus) juveniles produced in spring and autumn to viral hemorrhagic septicemia virus (VHSV) 이주연, 윤수영, 오명주 p. 483-488
양식 미꾸라지(Misgurnus mizolepis)로부터 분리된 Gentamicin-Resistant Aeromonas의 다제내성 분석 = Multiple antibiotic resistance analysis of gentamicin-resistant Aeromonas isolates from farmed loach (Misgurnus mizolepis) 임창용, 신기욱 p. 489-495
양식 동남아산 뱀장어(Anguilla bicolor)의 Lactococcus garvieae와 Aeromonas jandaei 복합감염 증례 = A case report of co-infection of Lactococcus garvieae and Aeromonas jandaei in cultivated shortfin eel (Anguilla bicolor) 허민도, 진지혜, 노을빛, 윤수영, 김보성 p. 497-502
Molecular characterization and genetic divergence of Ichthyophthirius multifiliis Fouquet, 1876 (Ciliophora) isolates from Korea Han-Seul Cho, Jeong-Ho Kim p. 503-509
Monitoring of parasitic and bacterial pathogens in farmed olive flounder in Wando, South Korea Yo-Seb Jang, Jeong-Hyeon Cho, Soo-Jin Kim, Han-Kyu Lim p. 511-516
두 가지 수온에서 약욕 투여 후 뱀장어(Anguilla japonica)에서의 oxolinic acid 혈청 약동학 = Serum pharmacokinetics of oxolinic acid in Japanese eel (Anguilla japonica) after bath treatment at two different water temperatures 정은하, 배준성, 이채원, 양찬영, 이지훈 p. 517-526