In this study, the optimal design of a large multicopter frame for special-purpose applications was conducted using Taguchi’s design of experiments method in conjunction with finite element analysis (FEA), with the aim of reducing the weight while maintaining structural robustness and reliability. The design variables considered were the inner angle, height, widthand frame thickness. An L (34) orthogonal array from the ₉ Taguchi method was employed to establish nine experimental conditions, enabling the influence of each factor. For each condition, vibration and hard-landing impact analyses were performed FEA to assess the structural stiffness and strength of the frame. signal-to-noise ratio analysis revealed that the frame width had the greatest influence on stiffness, whereas the frame thickness was the most significant factor affecting the strength. Under the optimized design conditions, a weight reduction of approximately 15% was achieved compared with the previous designwithout compromising the structural integrity. The results demonstrate the effectiveness of the proposed methodology in achieving a lightweight design while ensuring structural performanceand its potential applicability in the development of special-purpose and industrial-grade drone.