본문 바로가기 주메뉴 바로가기
국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

초록보기

Amyloid beta (Aβ) peptides, known for their involvement in neurodegenerative diseases like Alzheimer's, have recently been recognized as significant contributors to metabolic disorders, including type 2 diabetes. This study examined the effects of Aβ40 and Aβ42 peptides on cell viability and glucose-stimulated insulin secretion in rat insulinoma (INS-1) cells. Aβ40 treatment demonstrated no significant toxicity at lower concentrations; however, it did reduce cell viability at higher concentrations and with prolonged exposure. Conversely, Aβ42 exhibited notable cytotoxicity even at lower concentrations within 24 hours. The combined treatment of Aβ40 and Aβ42 at a 10:1 ratio further accelerated the decline in cell viability, indicating a synergistic toxic effect. Importantly, Aβ40/42 treatment did not impair glucose-stimulated insulin secretion in INS-1 cells under the conditions tested. These findings suggest that Aβ peptides may contribute to β-cell loss in type 2 diabetes through their cytotoxic effects, although the direct impact on insulin secretion requires further study. Nutritional interventions aimed at reducing Aβ aggregation and associated oxidative stress could offer promising strategies to protect β-cell viability, warranting further research to clarify the underlying mechanisms of such dietary modulation.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
캠벨얼리 주정 강화 와인의 숙성 온도와 기간에 따른 품질 특성 및 기능성 = Quality characteristics and functionality of campbell early fortified wine according to aging temperature and period 차정문, 윤동규, 박의광, 이윤정, 윤향식 p. 257-272
반응표면분석법을 이용한 에틸락테이트 용매 기반 주황색 고구마 기능성 성분 추출 최적화 연구 = Optimization of functional compound extraction from orange-fleshed sweet potato using ethyl lactate as a green solvent through response surface methodology 장가은, 유경단, 박유진, 김태화, 이교휘, 박원, 안종욱, 남상식, 우관식, 이형운, 정미남, 황엄지 p. 273-284
근적외선분광법을 활용한 고구마의 폴리페놀, 플라보노이드 함량 및 항산화활성 비파괴 분석 방법 확립 = Establishment of a non-destructive analysis method for the polyphenol, flavonoid content and antioxidant activity of sweetpotato using near-infrared reflectance spectroscopy 안종욱, 황엄지, 김태화, 박원, 이교휘, 남상식, 이형운, 정미남, 우관식 p. 285-293
효소처리에 따른 자색고구마 기능성 성분 추출 특성 = Effect of enzymatic treatment on the extraction of functional compounds from purple sweetpotato 황엄지, 장가은, 유경단, 박유진, 김태화, 박원, 이교휘, 안종욱, 정미남, 이형운, 우관식 p. 294-305
국내 육성 검은콩(Glycine max(L.) Merr.) 품종의 구조적, 열적, 수화 및 기능적 특성 비교 분석 = Comparative analysis of structural, thermal, hydration, and functional characteristics of black soybean (Glycine max (L.) Merr.) cultivars 예상진, 박현진, 최유찬, 함현미, 심은영, 박지영, 오현아, 강문석, 전원태, 천아름 p. 306-319
Dual enzymatic inhibition of tyrosinase and α-glucosidase by Petasites japonicus flavonoids and their skin-whitening potential Hyun-Suk Choi, DuBok Choi p. 320-330
약지도 학습을 활용한 AI 기반 한국 음식 재료 인식 의미론적 분할 모델 = AI-based weakly supervised semantic segmentation for Korean food ingredient recognition : bulgogi case study : 불고기 사례 연구 박영훈, 김영금, 최은영 p. 331-342
한국 성인에서 지속가능한 식생활 인식 및 실천 요인 분석 = Analysis of factors influencing perception and practice of sustainable diet among Korean adults 유현진, 정복미, 최미경, 배윤정 p. 343-353
(A) comparative analysis of the quality and instrumental flavor profiles of seasoned soy sauce prepared with different sub-ingredients Hye Kyung Cho, Kyung Tae Jang p. 354-369
말레이시아 소비자가 인식한 한국의 국가이미지가 한국 가정간편식(HMR) 제품태도와 구매의도에 미치는 영향 = The effect of Korea's national image on attitudes toward Korean home meal replacement (HMR) products and purchase intention among Malaysian consumers : the mediating effect of Korea's crisis response measures : 한국의 위기대응 조치의 매개효과 최승균, 박주현, 홍완수 p. 370-387
쪽파 뿌리 추출물의 항산화 및 항염증활성 = Anti-oxidant and anti-inflammatory activities of Allium wakegi Araki root extract 이윤성, 김지용, 서영호 p. 388-396
Nutritional perspectives on amyloid beta-mediated beta cell viability Eun-Young Park, Yoon Sin Oh p. 397-404