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Ischemic stroke (IS) has emerged as one of the leading causes of mortality and disability in adults worldwide. Hypoxia-inducible factor 1α (HIF-1α) signaling pathway plays a critical role in endogenous neuroprotective mechanisms following IS. Sargassum fusiforme is a significant marine algal resource. In previous research, we isolated bioactive fucoidan from acid-processed S. fusiforme, and demonstrated its anti-inflammatory and antioxidant efficacy. This study aimed to elucidate the role of S. fusiforme polysaccharides (SFPS) in promoting angiogenesis via the HIF 1α/vascular endothelial growth factor (VEGF) pathway following IS and to investigate the underlying mechanisms involved. In this study, we employed a hypoxia model in human cerebral microvascular endothelial cells (hCMECs/ D3) and a zebrafish IS model to elucidate the therapeutic mechanisms of SFPS in mitigating cerebral ischemic injury. Cellular assays confirmed the ability of fucoidan to prevent apoptosis and promote neovascularization in hCMEC/D3 cells under hypoxic stress. Furthermore, in a zebrafish IS model, fucoidan increased blood flow velocity and locomotor activity, while reducing neuronal apoptosis. Mechanistically, fucoidan activated the HIF-1α/VEGF signaling pathway in both cellular and animal models, thereby ameliorating hypoxic injury and stimulating angiogenesis. Results demonstrated the angiogenic activity of fucoidan in both in vitro and in vivo models, and revealed its key targets and associated pathways underlying its anti-ischemic effects. Findings collectively highlight the prospective utility of fucoidan as a marine-derived therapeutic agent from traditional Chinese medicine for neurovascular repair.

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기사명 저자명 페이지 원문 목차
In situ isolation of haloalkaliphilic microalga from the Yellow River delta : enhancing legume crop resilience under saline-alkali stresses Xiaoli Zhu, Minmin Xu, Jiahao Liang, Shenkun Liu, Xiao Yu, Yanpeng Pan, Guangwen Zhu, Xiaojing Wang, Jianchao Yang, Kang Wang, ZhiHai Zhong, Chenggang Ren, Hongli Cui, Song Qin p. 295-307
Spatiotemporal variations of phytoplankton functional groups and environmental drivers over the past two decades in the Bohai, Yellow and East China Sea Muhsan Ali Kalhoro, Veeranjaneyulu Chinta, Muhammad Tahir, Yujie Sheng, Chunli Liu, Zhiyuan He, Zhenlin Liang, Jun Song, Tony Song p. 309-334
Optimizing fucoxanthin production in the diatom Phaeodactylum tricornutum using ARTP-evolved mutant consortia and a multifaceted approach in LED-driven photobioreactors Wen Liu, Jing Liu, Song Zou, Jijian Long, Qin Zhang, Yue He, Hong Chen, Yan Liu, Yawen Fan, Qiang Hu p. 335-352
Lipidomic analysis exposes the role of lipids in the maturation of conchocelis of Pyropia haitanensis (Bangiales, Rhodophyta) Lin Liu, Yinghui Lin, Yan Xu, Dehua Ji, Chaotian Xie, Wenlei Wang p. 353-370
(A) brown seaweed Sargassum fusiforme polysaccharides protect against ischemic stroke by mediating angiogenic factors through the modulation of the HIF-1α/VEGF pathway Likun Chen, Xingyue He, YuXin Bai, Meijun Liu, Ying Meng, Mingdian Wu, Peng Zheng, Yulin Dai p. 371-386
Review of Sargassum thunbergii (Fucales, Phaeophyta) : phycology, chemistry, bioactivity, and application Xueyu Wang, Dandan Xiao, In-Kyu Yeo, Lei Wang, Yiqiao Li, Jia Fu, Yunhua Fu, Suengmok Cho, You-Jin Jeon, Fengqi Yang p. 387-426

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