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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Purpose: Biologic therapies have revolutionized the management of severe asthma (SA), yet the variability in patient responses necessitates identification/verification of predictive biomarkers. Siglec-8, a sialic acid-binding immunoglobulin-like lectin 8 selectively that is expressed on eosinophils, could serve as a biomarker for predicting responsiveness to biologics in patients with SA. It is necessary to evaluate the predictive value of baseline serum Siglec-8 levels compared to other parameters, including blood eosinophil counts, in determining clinical responses to anti-interleukin 5 (IL-5) therapies in patients with SA.

Methods: This study included 68 patients with SA from the Precision Medicine Intervention in Severe Asthma study, who had initiated anti-IL-5 therapies and whose baseline serum Siglec-8 levels were measured. Clinical outcomes were assessed at 6 and 12 months following treatment. Excellent responders were defined as patients with zero exacerbations during follow-up. Multivariable logistic regression and receiver operating characteristic curve analyses were performed to compare the predictive performance of serum Siglec-8 levels versus that of other parameters.

Results: Data from 29 patients treated with mepolizumab and 39 patients treated with reslizumab were analyzed. Baseline serum Siglec-8 levels showed a trend toward better diagnostic performance compared to blood eosinophil counts for predicting 6- and 12-month clinical responses (area under the curve, 0.931 vs. 0.836; P = 0.08 for 6-month responders; and 0.811 vs. 0.628, P = 0.05 for 12-month excellent responders). Additionally, the ratio of serum Siglec-8 levels to blood eosinophil counts significantly increased after 6 months of anti-IL-5 therapy (P < 0.001).

Conclusions: Baseline serum Siglec-8 levels showed a trend toward better predictive performance than other parameters for predicting 6- and 12-month responses to anti-IL-5 therapies in patients with SA. These findings suggest that Siglec-8 may have the potential as a biomarker for guiding treatment decisions, although further validation in larger, prospective studies is warranted.

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기사명 저자명 페이지 원문 목차
Update on tree nut and seed allergies : prevalence, clinical characteristics, diagnosis, and management Kyunguk Jeong, Sooyoung Lee p. 672-691
Efficacy of a combination therapy of montelukast and antihistamines in allergic rhinitis : a systematic review and network meta-analysis Ji-Sun Kim, Gulnaz Stybayeva, Se Hwan Hwang p. 692-708
Impact of biologics on nasal symptoms in severe asthmatics : findings from the PRISM study Ji-Su Shim, Hyunkyoung Kim, Jae-Woo Kwon, So-Young Park, Sujeong Kim, Byung-Keun Kim, Young-Hee Nam, Min-Suk Yang, Mi-Ae Kim, Sae-Hoon Kim ... [et al.] p. 709-725
Triglyceride-glucose body mass index predicts asthma exacerbations : a prospective study Fan Gao, Jiahui Lei, Yingjie Guo, Limin Zhao p. 726-741
Siglec-8 as a biomarker for predicting anti-IL-5 response in severe asthma Youngsoo Lee, Hyunkyung Kim, Chae Eun Lee, Byung-Jae Lee, Min-Hye Kim, So-Young Park, Byung Keun Kim, Sae-Hoon Kim, Sang Hoon Kim, Hye-Kyung Park ... [et al.] p. 742-753
Association between obstructive sleep apnea and atopic dermatitis in the Korean adult population : results from the 2019–2022 Korea National Health and Nutrition Examination Survey Jung Min Lee, Wanhyung Lee p. 765-774
Impact of antibiotic exposure on pediatric drug eruption : a nationwide cohort study in Korea Soo Min Jeon, Junwoo Jo, Juhee Ryu, Jin-Won Kwon, Jiung Jeong p. 775-786
Bronchodilator response of TEV/FEV3 and its implications in pediatric asthma Hamin Kim, Yoon Hee Kim, Jae Hwa Jung, Mireu Park, Yun Young Roh, Jong Deok Kim, Min Jung Kim, Yong Ju Lee, Kyung Won Kim, Myung Hyun Sohn, Soo Yeon Kim p. 787-796
(The) prevalence of allergic rhinitis in Korean children : nationwide surveys in the periods 1995-2022 Yong Ju Lee, Hye Mi Jee, Gitae Seo, Chae Hyun Im, Eun Lee, Dong In Suh, Jihyun Kim, You Hoon Jeon, So-Yeon Lee, Hyeon-Jong Yang, Kee-Jae Lee, Woo Kyung Kim, Kangmo Ahn, Hyo-Bin Kim p. 754-764

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