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Melanoma, the most lethal form of skin cancer, is closely associated with tyrosinase activity, making it a critical biomarker for early diagnosis. In this study, we developed a dual-mode biosensing platform integrating multicolorimetric and ratio-metric fluorometric detection for ultra-sensitive tyrosinase quantification. This platform leverages localized surface plas-mon resonance (LSPR) modulation of gold nanobipyramids (AuNBPs) alongside a fluorescence resonance energy transfer (FRET)-based mechanism using upconversion nanoparticles (UCNPs). The tunable LSPR of AuNBPs provided a bidirec-tional ratiometric multicolor emission improving sensitivity and selectivity. Tyrosinase-mediated oxidation of catechol to quinone inhibits silver (Ag) deposition on AuNBPs, inducing a distinct concentration-dependent color shift for precise visual quantification. This dual-modality assay achieves an exceptional limit of detection (LOD) of 4.13 × 10–5 and 2.71 × 10–5 U/ mL for colorimetric and fluorometric sensors, respectively, demonstrating high selectivity, robustness in complex biological samples. Additionally, the assay proved effective in screening tyrosinase inhibitors, using kojic acid as a model, and achieved an IC50 value of 61.45 µM, validating its inhibition efficiency.

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기사명 저자명 페이지 원문 목차
Design strategies for mechanically conformal electrical and electrochemical biosensors in integrated bioelectronic applications Philip Kim, Hye Min Seo, Hak Yong Kim, Haneul Kim, Myeong Jin Jeon, Jong Uk Lee, Hye Jin Kim p. 659-679
Recent advances in electrochemical and optical point-of-care testing for marine biotoxin detection Muniyandi Maruthupandi, Nae Yoon Lee p. 680-704
Fab2-SARAH : an Escherichia coli-based antibody fragment platform for scalable, cost-effective in vitro diagnostics Young Su Kim, Seo Yeong Oh, Hye‑Jeong Lee, Seong Uk Son, Hwabong Jeong, Hyeran Kim, Juyeon Jung, Young-Phil Kim, Eun-Kyung Lim, Jungoh Ahn p. 705-721
Nanopore fabrication using conventional 3D printer Sungyeol Kwak, Seongjun Hong, Bonggyo Seo, Yonghoon Cho, Howon Lee, Beomjoon Kim, Sungjae Ha, Sung Jae Kim p. 722-732
(A) robust, solvent-resistant paper-based platform for discriminative detection of organic solvents Gong Qian, Eun‑Bi Kim, Heon-Ho Jeong p. 733-740
Colorimetric detection of DDAC based on aggregation of gold nanoparticles modified with phage-displayed affinity peptides Ping Xu, Ruth Stephanie, Subhadeep Ghosh, Jong Pil Park, Chan Yeong Park, Tae Jung Park p. 741-750
Electrokinetic paper-based ion pre-concentrator for on-site detection of ionic water contaminants Yeonuk Yu, Junbeom Lim, Jina Choi, Rhokyun Kwak p. 751-760
Establishment and evaluation of immunocolloidal gold chromatography method in the sandwich mode for novel coronavirus double-antibody detection Hai Li, Han Wu, Changyan Yang, Jiayi Shu, Jianglong Wang, Haitao Li, Hefeng Zhou, Min Shao p. 761-770
Label-free impedance monitoring of the protective effect of salviae miltiorrhizae radix on glutamate-induced neurotoxicity Sungho Park, Do Hwi Park, Junhyung Cho, Ki Sung Kang, Sungbo Cho p. 771-781
Giga-ohm sealed 3D artificial cell membranes in microfluidic chips for advanced electrophysiology study Dong‑Hyun Kang, Bong Kyu Kim, Seok Chung, Tae Song Kim p. 782-793
Integrated colorimetric and fluorescent assay using gold nanobipyramids and UCNPs for tyrosinase-based melanoma diagnostics Mohamed R. Elmasry, Samy M. Shaban, Murad M.A. Abualrejal, Eslam Hafez, Ahmed Y. Elbalaawy, Siqi Sun, Dong-Hwan Kim p. 794-806
Development of a 3D vascularized skeletal muscle model using bi-layered seeding methods In U Kim, Jaesang Kim, Jessie S. Jeon p. 807-817
SARS-CoV-2 S1-inducing reactive astrocyte and proteinopathies via TANK-binding Kinase 1 in human neuroglia model Huyen Ngo, You Jung Kang, Yen N. Diep, Van Thi Ai Tran, Sein Kim, Sungsu Park, Luke P. Lee, Hansang Cho p. 818-835
(A) 3D microfluidic model of initial lymphatic vessels for investigating dendritic cell chemotaxis under inflammatory condition Hyeonsu Jo, Somin Lee, Inae Park, Mikang Shim, James Yu, Young Sun Oh, Junsang Doh, Young‑Kwon Hong, Noo Li Jeon p. 836-848
Fabrication of a contraction-free full-thickness human skin equivalent using skin-on-a-chip with silk fibroin scaffold Yoojin Na, Yunchul Kim, Jung Heon Lee, Gun Yong Sung p. 849-858

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