본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Background: White adipose tissue (WAT) browning can promote thermogenesis and could be a promising targetfor treating obesity. Rare ginsenosides transformed from stems and leaves of Panax ginseng (T-GSSL) exhibitnumerous biological activities. However, its potential anti-obesity effects and underlying mechanism remainlargely unknown.

Methods: Five amino acids were selected as the catalysts for the transformation of ginsenosides into rare ginsenosides.

An obese mouse model was established by feeding mice a high-fat diet (HFD) for 14 weeks. The effectsof T-GSSL on obese mice were assessed by measuring body weight, fat mass, energy expenditure (EE), andglucose tolerance. The 3T3-L1 cells were differentiated into mature adipocytes and incubated with T-GSSL.

Immunohistochemistry, co-immunoprecipitation (Co-IP), enzyme-linked immunosorbent assays (ELISA), westernblotting (WB), real-time polymerase chain reaction (PCR), and other methods were used to investigate the targetsand mechanisms of action of T-GSSL.

Results: Ginsenosides in GSSL were hydrolyzed using glutamic acid as a catalyst and 12 rare ginsenosides wereproduced, with a total conversion rate of 95 %. T-GSSL ameliorated metabolic disorders, lipid ectopic deposition,and obesity, and maintained glucose homeostasis in obese mice. T-GSSL treatment promoted adipose browningand enhanced EE in both HFD mice and 3T3-L1 cells. These effects were decreased in cells treated with a proteinkinase A (PKA) antagonist or subjected to PKAcα knockdown, whereas they were increased in REGγ􀀀 /􀀀 mice. Theinhibition of REGγ alongside the activation of the PKA/CREB pathway elucidates the mechanism through whichT-GSSL reverses obesity by promoting the browning of adipose tissue.

Conclusions: T-GSSL attenuates diet-induced obesity by promoting adipose browning through the inhibition ofREGγ and subsequent activation of the PKA/CREB pathway.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Antiviral potential of ginseng : targeting human pathogenic viruses with compounds derived from ginseng Chen Huo, Jihye Baek, Ki Hyun Kim p. 105-117
(A) narrative review of Panax notoginseng : unique saponins and their pharmacological activities Wenbiao Li, Hailian Shi, Xiaojun Wu p. 118-133
Total saponins from Panax Japonicus regulate the ferritin heavy chain to reduce inflammation in aging adipose tissue by mediating iron metabolism Leiqi Zhu, Jihong Zhang, Yaqi Hu, Yifan Zhang, Shuwen Wang, Rui Wang, Qi Yuan, Yiyang Luo, Ding Yuan, Yumin He, Chengfu Yuan p. 134-144
Synergistic effects of ginsenoside Rb1 and peroxiredoxin 6 in enhancing myocardial injury treatment through anti-inflammatory, anti-oxidative, and anti-apoptotic mechanisms Runhong Mu, Yupeng Li, Yunhe Cui, Chuanbo Feng, Tingyu Li, Tengda Liu, Mingzhu Chang, Xiao Guo, Xingcheng Yi p. 145-155
Rare ginsenosides transformed from stems and leaves of Panax ginseng reverse obesity by promoting browning of white fat through PKA/CREB pathway via REGγ negative regulation Jianbo Chen, Jiyue Sha, Xiaohui Huo, Zhiman Li, Di Qu, Xueqing Li, Meijia Li p. 156-165
Korean red ginseng relieves the inflammation and oxidative stress induced by pseudo-typed SARS-CoV-2 Hyeon Jin Kim, Yena Oh, Sohee Moon, Jieun Oh, Ji Hye Kim, Seung Ho Lee, Sun Hee Hyun, Ji Hye Park, Hun-kun Ko, Jaehyeon Hwang, Han Gyung Kim, Dae-Hyuk Kweon, Jae Youl Cho p. 166-178
Ginsenoside Rg1 exerts antidepressant effect by regulating hepatic kynurenine metabolism through promoting the interaction between HNF4α and PGC1α Keke Jia, Shuman Pan, Wenyuan Wu, Yiming Sun, Qingyu Zhang p. 179-188
Korean red ginseng-induced astrocytic HIF-1α : a key regulator of neuroglobin derived from neural stem cell differentiation in physiologic retina and brain Sunhong Moon, Jinseo Park, Sueun Kim, Minsu Kim, Hui Su Jeon, Hyungsu Kim, Young-Myeong Kim, Ji-Yoon Kim, Yoon Kyung Choi p. 189-196
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways Honglin Xu, Mingjie Pang, Changlei Hu, Tong Xu, Guanghong Chen, Guoyong Zhang, Xin Han, Yue Hua, Yuting Wu, Jiayi Zhang, Yiming Bi, Bin Liu, Yingchun Zhou p. 197-207
(The) molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on antiangiogenesis in cancer treatment : the battle between PI3K and ROS Qi-Rui Hu, Xin-Yi Zhong, Hua Feng, Xu-Chu Li, Zhi-Hong Zhang, Yao Pan, Ting Luo, Ze-Yuan Deng, Fang Chen p. 208-222

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기