본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis are characterized by a progressive loss of neurons driven by protein aggregation, neuroinflammation, and oxidative stress. Additionally, the blood–brain barrier (BBB) severely restricts the delivery of most therapeutics to the brain. In this context, cellulose and nanocellulose have emerged as sustainable drug delivery systems (DDSs) owing to their renewable biomass-based origin, excellent biocompatibility and biodegradability, high mechanical strength, and abundant surface hydroxyl groups that enable versatile chemical functionalization.

This review summarizes the structural and physicochemical properties of bulk, nanocrystal, nanofibril, and bacterial celluloses that are crucial for designing DDSs that can target the brain. These include a high specific surface area, as well as tunable network formation, surface charge, and hydrophilicity. The review highlights representative preclinical applications in major neurodegenerative diseases, such as cellulose ether-based oral formulations that modulate amyloid-β pathology, mucoadhesive carboxymethyl cellulose nasal nanocrystals for nose-to-brain delivery of dopaminergic agents, trehalose–cellulose systems targeting mutant huntingtin aggregation, and chitosan–nanocellulose hydrogels that support neural tissue repair.

Finally, it critically discusses the current relevance and limitations of cellulose-based DDSs compared with liposomal and polymeric nanoparticles and outlines future design strategies involving advanced surface func-tionalization, hybrid and multilayer architectures, integration with neural tissue engineering, and processes for regulatory standardization to enable clinical translation in neurodegenerative disease therapy.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Recent trends in life cycle assessment studies on pulp- and paper-based materials Seokmin Hong, Junhyeok Park, Semin Kang, Kyudeok Oh, Soojin Kwon p. 5-24
퇴행성뇌질환 치료를 위한 셀룰로오스 기반 약물전달시스템의 응용과 설계전략 = Applications and design strategies of cellulose-based drug delivery systems for the treatment of neurodegenerative diseases 우한웅, 서진호, 김지은 p. 25-40
Optimization of bacterial nanocellulose production from sweet potato waste via response surface methodology Lili Melani, Grace Brigitta Gunawan, Reso Aji Saputra Wicaksono, Gilang Mahendra Pratama p. 41-55
Preparation and characterization of methyl cellulose/pullulan/montmorillonite nanocomposite film for packaging applications Jungeon Lee, Jae Hoon Jung, Sabina Yeasmin, Neul-Sae-Rom Kim, Seong Baek Yang, Dong-Jun Kwon, Jung Wan Kim, Jeong Hyun Yeum p. 56-65
Study on the valorization of oak bark biomass. 1, Extraction and characterization of tannins Sa Rang Choi, Jung Myoung Lee p. 66-74
Study on the valorization of oak bark biomass. 2, Organosolv pulping of bark residue after tannin extraction Sa Rang Choi, Jung Myoung Lee p. 75-84
Effect of lignin recovery conditions from hardwood kraft black liquor on lignin characteristics Sa Rang Choi, Eon Jin Park, Jung Myoung Lee p. 85-93
(The) first record of cleistothecial Thermoascus crustaceus isolated from dried hardwood pulp in Korea Sunirmal Sheet, Marma Mamaching, Yang Soo Lee p. 94-102
오픈 헤드박스형 파일럿 초지기의 섬유 배향 분석 = Analysis of fiber orientation of paper using pilot machine with open headbox. 3, Effect of stock concentration and feeding speed. 3, 지료 농도 및 사출 속도에 따른 영향 최경화, 이광섭, 류정용 p. 103-110
AKD 및 PAE 복합화를 통한 나노셀룰로오스 기반 코팅지의 차단성 향상 = Enhancement of barrier properties of nanocellulose-based coated paper via AKD and PAE incorporation 채소영, 이학명, 김혜인, 박승욱, 유성민, 이건희, 윤혜정 p. 111-120
버섯 폐배지를 활용한 복합시트의 강도 및 표면 특성 향상 = Enhancement of mechanical and surface properties of composite sheets prepared using spent mushroom substrate 한승민, 최윤혁, 임완희, 정재훈, 전초현, 오지연, 이상수 p. 121-129

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기