본문 바로가기 주메뉴 바로가기
국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

초록보기

Tissue inhibitor of metalloproteinases 1 (TIMP1) is a multifunctional molecule that acts as the primary endogenous inhibitors of metalloproteinases (MPs). The imbalance between MMPs and TIMPs can lead to various cancers. We aim to prove the clinical and prognostic value of TIMP1 gene in colorectal cancer (CRC). TIMP1 mRNA expression was examined in various cancer types. We further evaluated survival to determine the prognostic significance of TIMP1 mRNA in CRC using The Cancer Genome Atlas (TCGA) data. The patients were divided into two subgroups, based on the TIMP1 gene expression levels to assess the clinical characteristics associated with TIMP1 expression. In rectal cancer, higher TIMP1 expression was linked to venous invasion, and there was also a correlated with histological type, location, and MSI types in colon cancer. Survival analysis showed that higher TIMP1 group was statistically associated with poorer prognosis. Our findings suggest that elevated TIMP1 mRNA expression is significantly associated with aggressive clinicopathological features and poor prognosis in CRC. TIMP1 may serve as a potential biomarker for risk stratification and a therapeutic target in CRC management.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Minimizing rectal toxicity in prostate cancer radiotherapy : from anatomical understanding to modern protective strategies : a narrative review Ye Won Kim, Seung Gyu Park, Euncheol Choi, Myeongsoo Kim, Byungyong Kim, Sang Jun Byun p. 273-281
한국인 시신에서 복장뼈길이를 이용한 키 추정 = Stature estimation from sternal length in Korean cadavers 김디귿, 최유진, 박광락, 조재호, 권형욱, 최윤일, 박정현 p. 283-290
Effect of cooling temperature on shrinkage and pressure-induced discomfort in thermoplastic head and neck immobilization masks for radiotherapy Yun Sung Shin, Young Min Kim, So Hyun Park, Myeongsoo Kim p. 291-302
한국인에서 칼돌기의 형태학적 분류 및 체질인류학적 특성 = Morphological classification and anthropological characteristics of the xiphoid process in Koreans 권형욱, 최유진, 조재호, 박광락, 김디귿, 최윤일, 박정현 p. 303-309
법의인류학분야 활용을 위한 사후전산화단층촬영영상 기반 위턱굴 부피 자동 계산 심층학습 모델 개발 = Development of deep learning-based model for automatic calculation of maxillary sinus volume using post-mortem computed tomograpy in forensic anthropology 이경수, Izzati Lia Wilda, 김예지, 문인경, 조병두, 윤용수 p. 311-318
조선시대 일기 쇄미록에 기록된 16세기 말 우리나라 서해안 지역 음식물 소비 양상에 대한 생물인류학적 검토 = Bioanthropological study of the late 16th-century dietary consumption pattern in the west coast region as recorded in the Joseon Dynasty diary Soemirok 신동훈, 홍종하, 신은경 p. 319-328
Clinical and prognostic value of TIMP1 in colorectal cancer Hyeok-Jun Moon, Yujoon Cha, Jae-Ho Lee, Junchae Lee p. 329-334
조선시대 회곽묘 출토 인골에서 발견된 과잉등뼈 = A case report of a supernumerary thoracic vertebra found in human remains from a lime-mortar burial of the Joseon Dynasty : 증례 보고 이성미, 김형철, 김주원, 김재현 p. 335-340
이상동기 살인사건에서 경부 예기 손상의 법의학적·해부학적 사례 분석 = Forensic and anatomical case analysis of cervical sharp-force injuries in an abnormal motive homicide 이근태 p. 341-346
Multi-breasts of Artemis of Ephesus through a plastic surgeon’s lens Kun Hwang p. 347-349