본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Background The clinical application of miR210, which possesses the capability to effectively alleviate renal interstitial fibrosis (RIF), is greatly constrained by its poor stability and lack of targeting abilities.

Methods A hyaluronic acid-modified N,N,N-trimethyl chitosan-poly (β-amino ester) nanoparticle encapsulating miR210 (HTP@miR210) was constructed. The serum stability, microscopic morphology, particle size, and zeta potential were characterized through gel electrophoresis, transmission electron microscopy, and dynamic light scattering. Subsequently, the cellular uptake capacity and targeting ability of the NPs were evaluated through fluorescence imaging. Furthermore, the biosafety was assessed via CCK-8 experiment, hemolysis test, and comprehensive blood chemistry examinations. Additionally, a TGF-β1-induced RIF cell model was established, and the therapeutic potential of HTP@miR210 against RIF in vitro was evaluated through qRT-PCR, Transwell assays, tube formation experiments, and Western blot (WB). Finally, a unilateral ureteral obstruction (UUO) rat model was constructed, and the therapeutic activity of HTP@miR210 against RIF was further verified using qRT-PCR, H&E staining, Masson's trichrome staining, immunohistochemistry, Flow cytometry (FCM), and WB.

Results HTP@miR210 exhibited a regular spherical shape. It demonstrated good stability in serum, as well as excellent biocompatibility and hemocompatibility. Additionally, it showed favorable renal targeting and promoted cell proliferation and angiogenesis. In animal experiments, HTP@miR210 effectively improved renal function and alleviated RIF. Specifically, it upregulated the expression of CD31 to promote angiogenesis and effectively inhibited the expression of α-SMA and fn1.

Conclusions This study underscored the tremendous potential of HTP@miR210 as an effective therapeutic approach for the treatment of RIF.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Clinical efficacy of stem cell therapy in neurotraumatic and neurodegenerative conditions : a comparative review Jun Beom Ku, Ray J. Pak, Sarah S. Ku, Robert D. Holland, Han-Soo Kim p. 1051-1066
Three-dimensional bioprinting and infertility-related female reproductive system diseases : a review of current and future applications Yanyan Liu, Yuanyuan Ma, Lihong Wang, Congmei Liu, Xianghua Huang, Jingkun Zhang p. 1067-1085
Hyaluronic acid-modified N,N,N-trimethyl chitosan-poly (β-aamino[i.e. amino] ester) nanocarriers loaded with miR210 for targeted inhibition of renal fibrosis Qin-ke Lv, Mou-ying Du, Ai-mei Gong, Yong-hua Zhu, Jia-yuan Li, Chun Yao, Jian Zhong p. 1087-1101
Fabrication and characterization of electrospun PCL/GelMA composite scaffolds for muscle tissue engineering Min Ji Hong, Goeun Bae, Won-Gun Koh, Karthika Muthuramalingam, Hyun Jong Lee p. 1103-1118
Mulberry silk worm pupae oil and prussian blue nanoparticle enriched multi-faceted polyvinyl alcohol nanofiber for infectious full thickness skin wound healing Manish Kumar, Dilip Kumar Arya, Salem Salman Almujri, Kumarappan Chidambaram, Prashant Pandey, Anit Kumar, Giriraj Pandey, Akash Sharma, Mohini Chaurasiya, M. Arockia Babu, R. Venkatesh Kumar, Ravi Kr. Gupta, Saurabh Srivastava, P.S. Rajinikanth p. 1119-1140
(A) novel scaffold-free engineered cartilage using combined chondrocyte pellets and sheets in chondrogenic differentiation medium Sopita Wongin-Sangphet, Pinprapha Sribenjarat, Pojchong Chotiyarnwong, Ekasame Vanitcharoenkul, Kwanchanok Viravaidya-Pasuwat p. 1141-1157
Human mesenchymal stem cell-derived skeletal muscle cell spheroids for treating dexamethasone-induced sarcopenia Yoonji Yum, Juhee Yoon, Yu Hwa Nam, Duk-Hee Kang, Sung-Chul Jung, Saeyoung Park p. 1159-1172
(The) effects of mesenchymal stem cell-derived exosomes on the attenuation of dry eye disease in sjögren syndrome animal model Youngseo Jeon, Soojung Shin, Eun Jeong Cheon, Yongmin Kwon, Jin Uk Beak, Hyun Jung Lee, Jaesung Park, So-Hyang Chung p. 1173-1183
Mycophenolic acid induces osteogenesis in tonsil-derived mesenchymal stem cells through inhibition of IMPDH and HDAC3 Young Min Choi, Yeseul Jang, Saeseul Choi, Yoon Shin Park, Se-Young Oh, Inho Jo p. 1185-1198
Derivation of granulosa-like cells from human endometrial iPSCs for autologous estradiol production Hyun Kyung Kim, Eun Jung Suh, SiHyun Cho, Young Sik Choi, Sinyoung Kim, Joo Hyun Park p. 1199-1210
Keratin scaffold formulation impacts rhBMP-2 biodistribution and bone regeneration in a rat femur defect model Justin M. Saul, Judy S. Bohnert, Molly O’Brien, Saif Alnuaimi, Troy P. Carnwath, Quinn Dunivan, Douglas W. Coffin, Thomas L. Smith p. 1211-1225
Human nasal olfactory stem cell-derived extracellular vesicles improve the repair of rat nerves Maxime Bonnet, Mostafa Seblani, Marie Witters, Tanguy Marqueste, Charlotte Jaloux, Philippe Morando, Patrick Decherchi, François Féron, Gaëlle Guiraudie-Capraz p. 1227-1240

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기