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T follicular helper (Tfh) cells are integral to the germinal center (GC) response and the development of potent humoral immunity. By priming B cells, Tfh cells can initiate both extrafollicular and GC-dependent Ab responses. The dynamic physical interactions between Tfh and B cells constitute the primary platform for Tfh cells to provide essential "help" factors to B cells, as well as for reciprocal signaling from B cells to sustain the helper state of Tfh cells. In recent years, significant advancements have been made in understanding the diverse roles of Tfh cells across various diseases, particularly in cancer. Notably, beyond the classical GC-Tfh cells, it is increasingly recognized that the Tfh cell phenotype is highly heterogeneous and dynamic, which adds complexity to their roles in disease contexts. This review aims to encapsulate progress in Tfh cell biology, with a focus on their role in cancer and immunotherapy.

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Anti-arthritis effect of anti-chitinase-3-like 1 antibody through inhibition of MMP3 Dae Hwan Kim, Ji Eun Yu, Dong Hun Lee, Min Ji Kim, Seong Hee Jeon, Jaesuk Yun, Dong Ju Son, Bongcheol Kim, Yoon Ji Yong, Young-soo Lim, Tae Hun Kim, Azizi Mohammad Khalid, Sang-Bae Han, Yong Sun Lee, Jin Tae Hong p. 1-19
Molecular biology and functions of T follicular helper cells in cancer and immunotherapy Mengyuan Xin, Antuo Wang, Minghao Ji, Jingru Wu, Bin Jiang, Mo Shi, Liang Song, Zhongwei Xin p. 1-15
Cytokines in focus : IL-2 and IL-15 in NK adoptive cell cancer immunotherapy Bryan Marr, Donghyeon Jo, Mihue Jang, Seung-Hwan Lee p. 1-33
Novel STAT3 Y360C gain-of-function variant underlies immune dysregulation and aberrancy in mitochondrial dynamics Kornvalee Meesilpavikkai, Kasiphak Kaikaew, Zijun Zhou, Virgil A.S.H. Dalm, Fabian M.P. Kaiser, Christopher Schliehe, Sigrid M.A. Swagemakers, Peter J. van der Spek, Benjamin Schrijver, Pamela Vasic ... [et al.] p. 1-20

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