본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Developmental and epileptic encephalopathies (DEEs), including Infantile Epileptic Spasms Syndrome (IESS) and Lennox-Gastaut Syndrome (LGS), are severe pediatric conditions characterized by profound developmental delays and treatment-resistant epilepsy. Although steroid therapies provide some clinical benefits, the underlying immunological mechanisms remain poorly understood. In this study, we performed comprehensive immune profiling using multi-parametric flow cytometry on PBMCs from IESS (n=25) and LGS (n=9) patients, comparing them with age-matched healthy controls (n=54). Our findings identified distinct patterns of immune dysregulation: IESS patients exhibited reduced naïve CD4+ T cells, an altered CD4/CD8 ratio, and diminished TNFα production in CD4+ T cells. Conversely, LGS patients demonstrated an increase in central memory CD4+ T cells, marked dysfunction of Tregs, and heightened activation of CD8+ T cells. Notably, elevated activated CD8+ T cells in IESS patients correlated significantly with clinical severity and demonstrated enhanced responsiveness to viral peptides, suggesting prior viral infections may exacerbate disease progression. Collectively, our findings demonstrate distinct immune signatures associated with disease severity and progression in DEE, suggesting their potential utility as biomarkers. Further studies are necessary to determine whether targeting these immune pathways could provide clinical benefits.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Pathotype-specific expression of granzyme-perforin pathway genes and their association with clinical disease activity in early rheumatoid arthritis and in a randomized clinical trial Francisco G. La Rosa, Larry W. Moreland, Luigi Nibali, Mike Curtis, Kevin D. Deane, Colin Strickland, Jennifer Seifert, Carson Keeter, Dmitri Simberg, Robert I. Scheinman, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers, Nirmal K. Banda p. 1-25
Pediatric atopic dermatitis exhibits distinctive patterns in JAK/STAT pathway activation and CD6-ALCAM signaling Soyoung Jeong, Sanghee Shin, Hyun Seung Choi, So-Jung Choi, Sehun Jang, Jeongmin Song, Ji Su Lee, Dong Hun Lee, Hyun Je Kim, Jihyun Kim, Kangmo Ahn p. 1-16
(A) novel approach of T cell receptor classification reveals dynamic interactions amongst diet, microbiota, and host T cells Jisun Jung, Jaeu Yi p. 1-11
Distinct T cell dysregulation reflects disease severity and progression in infantile epileptic spasms syndrome and Lennox-Gastaut syndrome Leechung Chang, Yeo-Jin Jeong, Haeun Chang, Hyeon Deok Sang, Ki-Nam Kwon, Su-Bin Lee, Si-Yoon Kim, You Min Kang, Sungji Ha, Se Hee Kim, Keun-Ah Cheon, Ho-Keun Kwon p. 1-18
Adoptive cellular therapies in pediatric leukemia patients after allogeneic-hematopoietic stem cell transplants Leanne Palichuk, Enoch Tin, Jongbok Lee p. 1-17
Arginine metabolism in cancer biology and immunotherapy DingYuan Bai, YuXuan Zhou, LingJie Jing, Cheng Guo, QuanJun Yang p. 1-17
Enigmatic roles of complement anaphylatoxin signaling in health and disease Anthony Shadid, Kathryn D. Hok, Aleksey Y. Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K. Banda, Marcos I. Restrepo, Pooja Shivshankar p. 1-46

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기