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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a curative potential for high-risk patients with leukemia following first-line therapies, driven by potent immune cell-dependent anti-tumour activities. Although deep remission can be achieved, many patients relapse after allo-HSCT, and further treatment options are scarce. Given the potent immune cell-mediated anti-leukemic effects of allo-HSCT, adoptive cellular therapies (ACTs) have been explored as an adjunctive therapy to enhance the efficacy of allo-HSCT or to treat patients who relapse after allo-HSCT. Interestingly, evidence suggests a stratified therapeutic approach is warranted between pediatric and adult leukemic cases, due to differences in genetic mutations and treatment tolerability. However, pediatric-specific investigations are limited, especially in the cellular therapeutic landscape to treat relapse after allo-HSCT. Known severe toxicities attributed to ACTs need to be addressed for this younger population to ensure prolonged quality of life. This review summarizes the current landscape of ACTs, including donor lymphocyte infusion, chimeric Ag receptor-T cell, NK cell, and double-negative T cell therapies, for treating pediatric leukemia post allo-HSCT, highlighting efficacy, safety, and gaps in pediatric-specific data to guide future research.

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권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Pathotype-specific expression of granzyme-perforin pathway genes and their association with clinical disease activity in early rheumatoid arthritis and in a randomized clinical trial Francisco G. La Rosa, Larry W. Moreland, Luigi Nibali, Mike Curtis, Kevin D. Deane, Colin Strickland, Jennifer Seifert, Carson Keeter, Dmitri Simberg, Robert I. Scheinman, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers, Nirmal K. Banda p. 1-25
Pediatric atopic dermatitis exhibits distinctive patterns in JAK/STAT pathway activation and CD6-ALCAM signaling Soyoung Jeong, Sanghee Shin, Hyun Seung Choi, So-Jung Choi, Sehun Jang, Jeongmin Song, Ji Su Lee, Dong Hun Lee, Hyun Je Kim, Jihyun Kim, Kangmo Ahn p. 1-16
(A) novel approach of T cell receptor classification reveals dynamic interactions amongst diet, microbiota, and host T cells Jisun Jung, Jaeu Yi p. 1-11
Distinct T cell dysregulation reflects disease severity and progression in infantile epileptic spasms syndrome and Lennox-Gastaut syndrome Leechung Chang, Yeo-Jin Jeong, Haeun Chang, Hyeon Deok Sang, Ki-Nam Kwon, Su-Bin Lee, Si-Yoon Kim, You Min Kang, Sungji Ha, Se Hee Kim, Keun-Ah Cheon, Ho-Keun Kwon p. 1-18
Adoptive cellular therapies in pediatric leukemia patients after allogeneic-hematopoietic stem cell transplants Leanne Palichuk, Enoch Tin, Jongbok Lee p. 1-17
Arginine metabolism in cancer biology and immunotherapy DingYuan Bai, YuXuan Zhou, LingJie Jing, Cheng Guo, QuanJun Yang p. 1-17
Enigmatic roles of complement anaphylatoxin signaling in health and disease Anthony Shadid, Kathryn D. Hok, Aleksey Y. Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K. Banda, Marcos I. Restrepo, Pooja Shivshankar p. 1-46

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