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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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An effective respiratory syncytial virus (RSV) vaccine should elicit neutralizing Abs and confer protection without causing vaccine-enhanced disease. Virus-like particle (VLP) is a safe vaccine platform that can display multivalent Ags similar to a virus and induce potent neutralizing Abs without adjuvant. We investigated the impact of mutations in the furin cleavage site, fusion (F) peptide, and change in the transmembrane (TM) domain of RSV F protein in VLPs on inducing RSV neutralizing Abs and efficacy in a cotton rat model. Palivizumab-binding antigenic site II epitope was preferentially exposed by combination mutations in the furin cleavage sites and F peptide together with a change in the TM domain. A single dose of mutant F protein VLP containing these combination mutations effectively induced IgG Ab responses to post-F and pre-F proteins, neutralizing activities, and protection without apparent lung histopathology. The VLP also induced the highest level of INF-γ, indicating the Th1-skewed immune response against the virus infection. A single dose of RSV F mutant exposing an antigenic site II on VLP vaccine could induce RSV-neutralizing Abs, conferring protection without causing vaccine-enhanced disease in cotton rats.

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TXNIP suppresses lung cancer progression by inhibiting TRAF6-mediated NF-κB activation and autophagy Ji Young Kim, Mi-Jeong Kim, Ji Hye Shin, Kyung-Hwa Baik, Yeeun Kang, Yoolim Sung, Seo Hyun Kim, Ha-Jeong Lee, Chaeeun Lee, Jae-Hyuck Shim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee p. 1-21
IL-22 exacerbates coxsackievirus type B3-induced pancreatitis by elevating viral replication through STAT3 activation Dae-Joon Kim, Jae-Hyoung Song, Jae-Hyeon Jeong, Jae-Hee Ahn, Jaewon Cho, Seo-Hyeon Mun, Eun-Hye Hong, Sungchan Cho, Sun-Young Chang, Dae Hee Kim, Hyun-Jeong Ko p. 1-18
Intestinal dysbiosis caused by epithelial Fabp6 gene disruption exacerbates gut inflammatory disease Kyeongeun Kwon, Minyoung Kim, Youngrak Jung, Mi Young Yoon, June-Yong Lee, Sang Sun Yoon, Mina Rho, Youn Wook Chung, Ji-Hwan Ryu p. 1-24
Unlocking IL-33 : new insights into tumor immunity Byeong Hoon Kang, Heung Kyu Lee p. 1-15
Virus-like particle vaccines containing RSV fusion protein cleavage mutations are immunogenic and protective in cotton rats with a prime dose Hye Suk Hwang, Young-Man Kwon, Ki-Hye Kim, Young-Tae Lee, Eun-Ju Ko, Arun Meas, Sang-Moo Kang p. 1-17
Comprehensive analysis of scRNA-seq and bulk RNA-seq identified TIMP1 as a prognostic marker in colorectal cancer Qian-Wen Luo, Yuan-Chao Shi, Wang-Qiang Jia, Xiao-Hai Zhou, Zheng-Rong Yang, Yan Wang, Quan-Lin Guan p. 1-22

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