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The Iroquois (Iro/Irx) gene family encodes transcription factors that belong to the Three-Amino-Acid Loop Extension-class homeodomain group, distinguished by a conserved Iro-box domain. Iroquois signaling is evolutionarily conserved from invertebrates to vertebrates and plays a vital role in embryonic development. In invertebrates, Iro/Irx genes control tissue compartmentalization, whereas in vertebrates, they regulate gastrulation, neural patterning, and organogenesis. These genes are typically organized in conserved genomic clusters under shared regulatory control, reflecting their coordinated expression and common evolutionary origins. Beyond development, dysregulation of Iroquois genes has been implicated in diverse human diseases. Iro/Irx genes are increasingly associated with congenital disorders, including congenital heart disease and neurodevelopmental abnormalities. Moreover, their emerging role in cancer biology has revealed context-dependent behavior, functioning as either tumor suppressors or oncogenes. Recent findings have also highlighted their potential as clinical biomarkers in neurological and neoplastic diseases. Given their broad developmental and pathological roles, Iroquois genes are gaining recognition as promising candidates for therapeutic targeting and molecular diagnostics. This review integrates their developmental functions with their disease associations to provide a comprehensive overview of the biological and clinical significance of Iroquois signaling.

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기사명 저자명 페이지 원문 목차
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Female reproductive disease, endometriosis : from inflammation to infertility Wonhyoung Park, Whasun Lim, Miji Kim, Hyewon Jang, Soo Jin Park, Gwonhwa Song, Sunwoo Park p. 1-10
Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity Mohaddeseh Ghorbani Shiraz, Janni Nielsen, Jeremias Widmann, Ka Hang Karen Chung, Thomas Paul Davis, Casper Rasmussen, Carsten Scavenius, Jan J. Enghild, Camille Martin-Gallausiaux, Yogesh Singh, Ibrahim Javed, Daniel E. Otzen p. 1-15
Exploring the multifaceted functions of APPL in metabolism and memory using Drosophila melanogaster Dharmendra Kumar Nath, Youngseok Lee p. 1-13
Genome-wide statistical evidence elucidates candidate factors of life expectancy in dogs Won Hee Ko, Sangil Kim, Alix Catry, Je-Yoel Cho, Seunggwan Shin p. 1-7
Crystal structure of γ-carbonic anhydrase from the polyextremophilic bacterium Aeribacillus pallidus Seung Hun Choi, Mi Sun Jin p. 1-9
(The) disordered effector RipAO of Ralstonia solanacearum destabilizes microtubule networks in Nicotiana benthamiana cells Hyelim Jeon, Wanhui Kim, Cécile Segonzac p. 1-14
Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis Suji Kim, Ae-Rang Hwang, Sun-Hee Kim, Jae Hyang Lim, Chang-Hoon Woo p. 1-8
Brief guide to immunostaining Gyutae Park, Sieun S. Kim, Jiwon Shim, Seung-Jae V. Lee p. 1-5
Dysregulated RNA-binding proteins and alternative splicing : emerging roles in autism spectrum disorder Jiwon Jeong, Hee-Jeong Yoo, Joon-Yong An, Sunjoo Jeong p. 1-17
Advancing precision diagnosis in autism : insights from large-scale genomic studies Soo-Whee Kim, Joon-Yong An p. 1-17
Optogenetics to biomolecular phase separation in neurodegenerative diseases Kyung Hwan Park, Kyung Won Kim p. 1-12
Building blocks for lung regeneration : stem cells and niches Hyeyoung Lee, Chae Won Lim, Woo Ram Lee, Ji Eun Park, Da Yeon Yu, Jinwook Choi p. 1-10
RNA-associated nuclear condensates : where the nucleus keeps its RNAs in check Doyeong Ku, Yewon Yang, Yoosik Kim p. 1-13
Pattern recognition receptors and inflammasome : now and beyond SuHyeon Oh, Young Ki Choi, SangJoon Lee p. 1-12
Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner Linni Jin, Chul Hoon Kim, Jeong Taeg Seo, Seok Jun Moon p. 1-12
Brief guide to gene cloning Woojin Hong, Seokjun G. Ha, Hyunwoo C. Kwon, Seung-Jae V. Lee p. 1-7
Brief guide to assays for measuring health parameters using Caenorhabditis elegans Seungjae Hwang, Jongsun Lee, Seung-Jae V. Lee p. 1-5
Brief guide to Caenorhabditis elegans survival assays Hyunwoo C. Kwon, Seung-Jae V. Lee p. 1-6
READRetro web : a user-friendly platform for predicting plant natural product biosynthesis Yejin Kwak, Taein Kim, Sang-Gyu Kim, Jeongbin Park p. 1-5
(A) brief guide to analyzing TurboID-based proximity labeling-mass spectrometry in plants Tae-Ki Park, Tae-Wuk Kim p. 1-5
Analysis of mitochondrial membrane potential, ROS, and calcium Hye-Kyung Park, Byoung Heon Kang p. 1-4
Crucial roles of calcium ATPases and phosphoinositides : insights into pathophysiology and therapeutic strategies Hyun-Oh Gu, Seung Wan Noh, Ok-Hee Kim, Byung-Chul Oh p. 1-13
Role of expression quantitative trait loci (eQTL) in understanding genetic mechanisms underlying common complex diseases Sung Eun Hong, Murim Choi, Jeongha Lee p. 1-10
Multifaceted role of serine hydroxymethyltransferase in health and disease Jing Zhang, Seong Eun Lee, Jiyeon Yoon, Bon Jeong Ku, Junyoung O. Park, Da Hyun Kang, Jun Young Heo, Yea Eun Kang p. 1-21
Cyclotides as novel plant-derived scaffolds for orally active cyclic peptide therapeutics Youbong Hyun p. 1-8
Phosphatase regulation in cell division : with emphasis on PP2A-B56 Junsoo Oh, Yeseul Park, Shinae Park, Og-Geum Woo, Jae-Hoon Lee, Jung-Shin Lee, Taekyung Kim p. 1-9
N-terminal deleted isoforms of E3 ligase RNF220 are ubiquitously expressed and required for mouse muscle differentiation SeokGyeong Choi, Sojung Ha, Donald J. Wolfgeher, Jee Won Kim, Young-Hyun Go, Hyuk-Jin Cha, Gyu-Un Bae, Stephen J. Kron, Woo-Young Kim p. 1-7
Tumor-derived CD84 promotes growth of acute myeloid leukemia cells via regulating nonhomologous DNA end-joining pathway Xiang Li, Bo Chen, Jiajing Zhou, Chunling Li, Yue Yu, Erdi Zhao, Xingli Wu, Changzhu Jin, Minjing Li, Jiankai Feng, Leilei Lin, Yancun Yin p. 1-15
Brief guide to Caenorhabditis elegans imaging and quantification Hyemin Min, Gyutae Park, Seung-Jae V. Lee p. 1-5
(A) practical guide to ordering C. elegans strains for biological research Yeon-Ji Park, Kyeong Min Moon, Kyuhyung Kim p. 1-4
Iron metabolism dysregulation and ferroptosis : emerging drivers in pulmonary fibrosis pathogenesis and therapy Yawen Jiang, Ligang Zhang, Yuandong Lin, Xiangxing Zhu, Tao Wang, Zhu Zhu, Yingshan Chen, Dongsheng Tang p. 1-18
Rationale and emerging evidence for microglial replacement in Alzheimer’s disease Jee Yoon Bang, Yongjin Yoo p. 1-13
Identification and application of bioparts for plant synthetic biology Hyunjin Koo, Minah Jung, Sangwoo Lee, Sangjin Go, Yong-Min Kim p. 1-10
Identification of a unique subpopulation of mucosal fibroblasts in colorectal cancer with tumor-restraining characteristics Jamin Ku, Eunjin Jeong, Jeong-Ryeol Gong, Kwang-Hyun Cho, Chang Ohk Sung, Seok-Hyung Kim p. 1-18
Current therapeutic strategies in Parkinson’s disease : future perspectives Tae Young Kim, Byoung Dae Lee p. 1-11
Dual SMAD inhibition as a versatile platform in human pluripotent stem cell–based regenerative medicine and disease modeling Lesly Puspita, Magdalena Deline, Jae-won Shim p. 1-16
Decoding genomic rearrangements for cancer driver discovery Enyoung Seo, Sooyeon Park, Inho Park, Jinhyuk Bhin p. 1-11
Post ingestive systemic nutrient sensing for whole-body homeostasis Gahbien Lee, Jiyeon Lee, Greg S.B. Suh, Yangkyun Oh p. 1-13
Charge-dependent localization of Toll-like receptor 5 at the plasma membrane Ji-Won Huh, Kwangcheon Park, Hyun-Sup Song, Seongryong Kim, You-Me Kim p. 1-7
Brief guide to detecting ferroptosis Thu-Hang Thi Nghiem, Fedho Kusuma, Jeongmin Park, Yeonsoo Joe, Hun Taeg Chung, Jaeseok Han p. 1-10
Immune cell isolation from lymphoid and nonlymphoid organs Jong Seok Park, Yoontae Lee p. 1-5
GOREA : unbiased interpretation of functional enrichment Hojin Lee, Young-In Park, Ina Jeon, Dawon Kang, Harim Chun, Jungmin Choi p. 1-6
Recent preclinical and clinical advances in gene therapy for hereditary hearing loss Seung Hyun Jang, Hyeong Gi Song, Jinsei Jung, Heon Yung Gee p. 1-12
Multifaceted role of Iroquois signaling in development and diseases Ravi Shankar Goutam, Neha Kaushik, Basant Kumar, Woochan Jung, Santosh Kumar, Seung-Hwan Lee, Unjoo Lee, Jaebong Kim p. 1-16
Egr2-dependent Mo-DCs regulate immunosuppressive NK cells, promoting neutrophil-mediated protective immunity against acute Listeria infection Muhammad Umer Ashraf, Myeong-Ho Kang, Yong Taik Lim, Siyoung Yang, Yong-Soo Bae p. 1-19
Ionotropic receptors mediate arachidic acid perception and food avoidance behavior in Drosophila melanogaster Roshani Nhuchhen Pradhan, Muhammad Atif, Youngseok Lee p. 1-13
Deficient chaperone-mediated autophagy in macrophages aggravates colitis and colitis-associated tumorigenesis in mice Weichun Zhu, Zehao Chen, Yunqian Gao, Chungang Zhai, Xia Li, Ning Wang, Kang Fu, Wentao Chen, Jieqiong Peng, Dan Xu, Lei Qiao, Wenqiang Chen p. 1-17
Approaches to murine T cell isolation and activation Sangjun Lim, Sohyun Kum, Jin Ouk Choi, Joonbeom Bae, Soo Seok Hwang p. 1-5
Brief guide to western blot assays Seokjun G. Ha, Ji-Hoon Park, Mi-Young Kim, Seung-Jae V. Lee p. 1-5
THRAISE : an automated and reproducible web platform for RNA-seq analysis Hyeon Ho Heo, Soo-Jong Um p. 1-7

참고문헌 (112건) : 자료제공( 네이버학술정보 )

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