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Chemosensory functions are essential for animals to distinguish between nutritious and harmful compounds. Fatty acids are vital dietary components, but their taste perception mechanisms remain poorly understood. In Drosophila melanogaster, we identified a cluster of ionotropic receptors (IR7g, IR25a, IR51b, IR67a, and IR76b) that mediate the detection of the long-chain saturated fatty acid, arachidic acid (ARCH), through bitter-sensing gustatory receptor neurons. Our findings demonstrate that high doses of ARCH elicit strong aversive responses and exhibit toxic effects, decreasing survival rates in a dose-dependent manner. ARCH detection was found to require the activation of bitter-sensing gustatory receptor neurons, and the inhibition of sugar-sensing neurons contributed to diminished feeding responses. This study provides critical insights into the molecular and neural mechanisms underlying fatty acid perception in Drosophila, opening new avenues for understanding how animals manage dietary lipid intake and its implications for health.

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Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity Mohaddeseh Ghorbani Shiraz, Janni Nielsen, Jeremias Widmann, Ka Hang Karen Chung, Thomas Paul Davis, Casper Rasmussen, Carsten Scavenius, Jan J. Enghild, Camille Martin-Gallausiaux, Yogesh Singh, Ibrahim Javed, Daniel E. Otzen p. 1-15
Exploring the multifaceted functions of APPL in metabolism and memory using Drosophila melanogaster Dharmendra Kumar Nath, Youngseok Lee p. 1-13
Genome-wide statistical evidence elucidates candidate factors of life expectancy in dogs Won Hee Ko, Sangil Kim, Alix Catry, Je-Yoel Cho, Seunggwan Shin p. 1-7
Crystal structure of γ-carbonic anhydrase from the polyextremophilic bacterium Aeribacillus pallidus Seung Hun Choi, Mi Sun Jin p. 1-9
(The) disordered effector RipAO of Ralstonia solanacearum destabilizes microtubule networks in Nicotiana benthamiana cells Hyelim Jeon, Wanhui Kim, Cécile Segonzac p. 1-14
Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis Suji Kim, Ae-Rang Hwang, Sun-Hee Kim, Jae Hyang Lim, Chang-Hoon Woo p. 1-8
Brief guide to immunostaining Gyutae Park, Sieun S. Kim, Jiwon Shim, Seung-Jae V. Lee p. 1-5
Dysregulated RNA-binding proteins and alternative splicing : emerging roles in autism spectrum disorder Jiwon Jeong, Hee-Jeong Yoo, Joon-Yong An, Sunjoo Jeong p. 1-17
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Optogenetics to biomolecular phase separation in neurodegenerative diseases Kyung Hwan Park, Kyung Won Kim p. 1-12
Building blocks for lung regeneration : stem cells and niches Hyeyoung Lee, Chae Won Lim, Woo Ram Lee, Ji Eun Park, Da Yeon Yu, Jinwook Choi p. 1-10
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Pattern recognition receptors and inflammasome : now and beyond SuHyeon Oh, Young Ki Choi, SangJoon Lee p. 1-12
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Brief guide to gene cloning Woojin Hong, Seokjun G. Ha, Hyunwoo C. Kwon, Seung-Jae V. Lee p. 1-7
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참고문헌 (76건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Molecular basis of fatty acid taste in Drosophila 미소장
2 Coordination and fine motor control depend on Drosophila TRPγ 미소장
3 Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1 미소장
4 Molecular and neuronal mechanisms for amino acid taste perception in the Drosophila labellum 미소장
5 Protocol for binary food choice assays using Drosophila melanogaster 미소장
6 Molecular and cellular basis of sodium sensing in Drosophila labellum 미소장
7 Taste detection of flonicamid in Drosophila melanogaster 미소장
8 Fatty acids in cardiovascular health and disease: a comprehensive update 미소장
9 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila 미소장
10 Human senses and sensors from Aristotle to the present 미소장
11 Ir56d-dependent fatty acid responses in Drosophila uncover taste discrimination between different classes of fatty acids 미소장
12 A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans 미소장
13 The molecular basis for water taste in Drosophila 미소장
14 The role of the TRP channel NompC in Drosophila larval and adult locomotion 미소장
15 Presynaptic gain control drives sweet and bitter taste integration in Drosophila 미소장
16 A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila 미소장
17 Two Gr genes underlie sugar reception in Drosophila 미소장
18 The various roles of fatty acids 미소장
19 Taste receptors of the gut: emerging roles in health and disease 미소장
20 Evolution of fatty acid taste in drosophilids 미소장
21 Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster 미소장
22 Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila 미소장
23 Drosophila TRP channels and animal behavior 미소장
24 Dual mechanism for bitter avoidance in Drosophila 미소장
25 A molecular and cellular context-dependent role for Ir76b in detection of amino acid taste 미소장
26 Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila 미소장
27 NOMPC is likely a key component of Drosophila mechanotransduction channels 미소장
28 Taste and the history of science: introduction 미소장
29 Differentiated response to sugars among labellar chemosensilla in Drosophila 미소장
30 A complex peripheral code for salt taste in Drosophila 미소장
31 Mechanosensory neurons control sweet sensing in Drosophila 미소장
32 An odorant-binding protein required for suppression of sweet taste by bitter chemicals 미소장
33 Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila 미소장
34 Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception 미소장
35 Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway 미소장
36 Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons 미소장
37 Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal 미소장
38 Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade 미소장
39 Avoiding DEET through insect gustatory receptors 미소장
40 Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster 미소장
41 Multiple gustatory receptors required for the caffeine response in Drosophila 미소장
42 A Drosophila gustatory receptor required for strychnine sensation 미소장
43 Calcium taste avoidance in Drosophila 미소장
44 Drosophila hygrosensation requires the TRP channels water witch and nanchung 미소장
45 ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster 미소장
46 Gender-specific effects of pro-longevity interventions in Drosophila 미소장
47 Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons 미소장
48 A molecular mechanism for high salt taste in Drosophila 미소장
49 Suppression of male courtship by a Drosophila pheromone receptor 미소장
50 Drosophila sensory receptors—a set of molecular Swiss Army Knives 미소장
51 A taste receptor required for the caffeine response in vivo 미소장
52 A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship 미소장
53 The Drosophila light-activated conductance is composed of the two channels TRP and TRPL 미소장
54 Acid and alkali taste sensation 미소장
55 Avoiding alkaline taste through ionotropic receptors 미소장
56 Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization 미소장
57 Cholesterol taste avoidance in Drosophila melanogaster 미소장
58 Molecular basis of hexanoic acid taste in Drosophila melanogaster 미소장
59 Molecular basis of hexanoic acid taste in Drosophila melanogaster 미소장
60 Avoiding cantharidin through ionotropic receptors 미소장
61 Mechanism of acetic acid gustatory repulsion in Drosophila 미소장
62 A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster 미소장
63 Gustatory processing in Drosophila melanogaster 미소장
64 The taste of vitamin C in Drosophila 미소장
65 Mechanisms of carboxylic acid attraction in Drosophila melanogaster 미소장
66 Mechanisms of DEET gustation in Drosophila 미소장
67 Molecular sensors in the taste system of Drosophila 미소장
68 Cellular and molecular basis of IR3535 perception in Drosophila 미소장
69 Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster 미소장
70 Contact chemoreceptors mediate male-male repulsion and male-female attraction during Drosophila courtship 미소장
71 Painless, a Drosophila gene essential for nociception 미소장
72 Fatty acids and cardiovascular risk. Evidence, lack of evidence, and diligence 미소장
73 A flagellar polycystin-2homolog required for male fertility in Drosophila 미소장
74 Role of taste receptors in innate immunity and oral health 미소장
75 The molecular basis for attractive salt-taste coding in Drosophila 미소장
76 Food experience–induced taste desensitization modulated by the Drosophila TRPL channel 미소장

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