본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Objective We estimated the prevalence of statin intolerance (SI) in a Portuguese primary care population, applying the CLEAR Outcomes trial inclusion criteria.

Methods This retrospective study analyzed electronic health records (EHRs) from the Local Health Unit of Matosinhos, Portugal (from system launch through December 2023). The study included both men and women (postmenopausal, surgically sterile, or using birth control) aged 18–85 years, with a history of atherosclerotic cardiovascular disease (ASCVD) or at high/very-high ASCVD risk, and a low-density lipoprotein cholesterol (LDL-C) level ≥100 mg/dL while receiving lipid-lowering therapies. The index date was defined as the date when each patient met all eligibility criteria. SI (the prescription of ≥2 statins at any dose, or 1 statin at any dose in patients unwilling to try a second statin) was identified through free-text search. Univariate logistic regression analyses were performed.

Results In total, 12,393 patients were eligible for inclusion. SI was observed in 9.6% (n=1,195) of patients, who in December 2023 had a median (1st to 3rd quartiles) age of 73 years (68–78 years) and a median LDL-C of 100 mg/dL (76–129 mg/dL). Most patients were male (55.2%), had ≥3 comorbidities (78.2%), and 42.1% were prescribed a moderate-intensity statin. Individuals aged ≥70 years had a higher likelihood of SI (odds ratio [OR], 1.3; 95% confidence interval [CI], 1.1–1.4). Women showed a non-significantly higher likelihood of SI (OR, 1.1; 95% CI, 0.9–1.2).

Conclusion The prevalence of SI observed in this study is consistent with existing literature and is particularly elevated in older individuals. These findings highlight the need to prioritize alternative therapies for dyslipidemia in this population.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
(A) position paper on lipoprotein(a) from the lipoprotein(a) task force of the Korean Society of Lipid and Atherosclerosis : current evidence, clinical applications, and future directions Youngwoo Jang, Jang Hoon Lee, Sang-Guk Lee, Hun Jee Choe, Sang Min Park, In-Kyung Jeong, Byung Jin Kim p. 2-25
Selected genes associated with CVD-related diseases, pathways, and nutrigenetics Seyma Sehadet Tasdemir, Gamze Akbulut p. 26-47
(The) role of galectin-3 in atherosclerosis and its cardiovascular complications : an update Pedro Bortoleto Colombo, João Victor Silveira Camargo, Vanessa Leiria Campo, Marcelo Fiori Marchiori, Aline Barbosa Ribeiro p. 48-56
Atherosclerosis progression in native coronaries after coronary artery bypass grafting : a state-of-the-art review Hesham Salah El-Din Taha, Omar Younis, Mirna Mamdouh p. 57-71
Olezarsen and beyond : emerging targeted treatments for familial chylomicronemia syndrome and related triglyceride disorders Meghashree N, Kushal CB, Shivaraj DR p. 72-87
(The) relationship between low-density lipoprotein cholesterol levels and cardiovascular risk in Koreans with and without diabetes Ji Hye Heo, Taehwa Go, Dae Ryong Kang p. 88-97
Associations of changes in metabolic syndrome status and risk factor count with incident cardiovascular events among cancer survivors Jaeyong Lee, Hyeok-Hee Lee, Eun-Jin Kim, Hyeon Chang Kim, Hokyou Lee p. 98-110
Associations of dietary intake with cardiovascular diseases, blood pressure, and lipid profile in the Korean population : an updated systematic review and meta-analysis Jeongseon Kim, Madhawa Gunathilake, Tung Hoang, Oh Yoen Kim p. 111-137
Prevalence of statin intolerance in a primary care Portuguese population : a retrospective cohort study Cristina Gavina, Francisco Araújo, Ana Rita Luz, Cristina Jácome Jorge A. Ruivo, Carla Teixeira p. 138-150
Association between lipid-lowering drug use and sarcopenia : analysis of the Korea National Health and Nutrition Examination Survey Ah-Reum Shin, Keun-Gyu Park, Sung-Woo Kim p. 151-160
Hypertriglyceridemia in type 2 diabetes is associated with T regulatory cell dysfunction Karthik Raj, Seema Garg, Mohit Mehndiratta, SV Madhu, Rajarshi Kar, Edelbert Anthonio Almeida p. 161-172
Tigloylgomisin P inhibits endothelial inflammation by regulating the NF-κB and Smad1/5/9 pathways Minjeong Shin, Junhyeon Ku, Jenita Immanuel, Nayeong Kwon, Sanguk Yun p. 173-182
Hypercholesterolemia successfully treated with two different PCSK9 inhibitors in a patient with glycogen storage disease IXd : phosphorylase kinase deficiency Tiffany Huynh, Hien Nguyen, Michelle Nguyen p. 183-192

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기