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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Objectives. The prognostic value of the pretreatment albumin-to-alkaline phosphatase ratio (AAPR) in head and neck cancer (HNC) remains uncertain. This meta-analysis aimed to evaluate the predictive role of AAPR for survival outcomesin patients with HNC.

Methods. A comprehensive search of the Cochrane Library, PubMed, and Embase databases was conducted to identify relevant studies published up to July 30, 2024. We included studies on AAPR and survival outcomes in HNC patients.

Results. Eight studies comprising 1,737 HNC patients were analyzed using random-effects models. Lower AAPR valueswere significantly correlated with worse overall survival (hazard ratio [HR], 2.08), progression-free survival (HR, 2.00),and disease-free survival (HR, 2.18). Sensitivity analyses confirmed the robustness of these results, with no significantpublication bias detected.

Conclusion. Our findings suggest that pretreatment AAPR could serve as a valuable and cost-effective prognostic indicatorin HNC, potentially aiding clinicians in risk stratification and treatment decision-making. However, additional validation studies are warranted to confirm its clinical applicability.

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Prognostic utility of the albumin-to-alkaline phosphatase ratio in head and neck cancer : a systematic review and meta-analysis Yun-Ting Wang, Adarsh Kudva, Yen-Ting Lu, Liang-Tseng Kuo, Chia-Hsuan Lai, Yuan-Hsiung Tsai, Chun-Ta Liao, Ku-Hao Fang, Chung-Jan Kang, Ethan I. Huang, Cheng-Ming Hsu, Geng-He Chang, Ming-Shao Tsai, Yao-Te Tsai p. 45-54
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Synergistic exacerbation of allergic inflammation by combined exposure to air-pollutants in a murine model of allergic rhinitis Joo-Hoo Park, Jee Won Moon, Yeong-In Jo, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun-Woo Yang, Dae Jin Song, Il-Ho Park p. 86-96
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