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The pathophysiology of patent ductus arteriosus (PDA) is conventionally attributed to increased pulmonary blood flow and reduced systemic organ perfusion caused by left-to-right ductal shunting. Although PDA has been associated with major complications of prematurity and neurodevelopmental impairment, establishing direct causality remains challenging due to multiple confounders, including interactions among risk factors inherent to prematurity, variability in PDA severity and exposure duration, and the effects of interventions themselves. Accumulating evidence supports interpreting PDA in preterm infants as a biomarker of physiological vulnerability and comorbidity severity rather than as a primary causative condition. Prophylactic or early routine pharmacological closure has not demonstrated consistent benefits over conservative management with expectant closure in terms of mortality, short-term morbidity, or long-term neurodevelopmental outcomes. Prospective studies have confirmed that conservative management is a viable treatment strategy even in extremely preterm infants born before 28 weeks of gestation. Major international guidelines recommend that closure be considered only when echocardiographic evidence of hemodynamic compromise is accompanied by clinical symptoms, with pharmacological therapy as the first-line treatment. When pharmacological treatment fails or is contraindicated, the choice and timing of transcatheter ductal occlusion or surgical ligation should be determined based on the patient’s cardiorespiratory status, comorbidities, institutional availability, and anticipated risks. PDA management should be guided by the clinical judgment of experienced neonatologists with comprehensive knowledge of each patient rather than by adherence to uniform protocols. In the domestic neonatal care setting, individualized management strategies developed through multidisciplinary collaboration should be given appropriate consideration.

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기사명 저자명 페이지 원문 목차
Clinical significance and treatment strategies of patent ductus arteriosus in preterm infants : an evidence-based approach to decision-making Soon Min Lee, Byong Sop Lee, Mi Young Han, Hyun Ho Kim, Teahyen Cha, Seung Hyun Kim, Ju Sun Heo, Eui Kyung Choi, Yeong Myong Yoo, Kee Hyun Cho, Byoungkook Lee, Eun Song Song, Se In Sung, Yun Sil Chang p. 4-17
미숙아 동맥관개존증의 임상적 의미와 치료 전략 : 대한신생아학회 권고문 이순민, 이병섭, 한미영, 김현호, 차태현, 김승현, 허주선, 최의경, 유영명, 조기현, 이병국, 송은송, 성세인, 장윤실 p. 18-29
Perinatal factors and postnatal growth trajectories as determinants of school-age pulmonary function in preterm infants Jihye Yoon, Seung Han Shin, Baek Sup Shin, Ji Soo Park, Dong In Suh, Dabin Kim, Gyeong Eun Yeom, Seh Hyun Kim, Ju Sun Heo, Ee-Kyung Kim, Han Suk Kim p. 30-38, [1-3]
Current infrastructure for surgical management including patent ductus arteriosus ligation in Korean neonatal intensive care units : a nationwide survey Sung-Hoon Chung, Jong-Hee Hwang, Survey and Statistics Committee of the Korean Society of Neonatology p. 39-48
Establishing cohort-specific reference values for terme-quivalent age brain magnetic resonance imaging abnormality scores in a Korean cohort Dabin Kim, Hae Min Kang, Ji Hye Yoon, Jieun Jeong, Gyeong Eun Yeom, Baek Sup Shin, Seh Hyun Kim, Ju Sun Heo, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim p. 49-55
Real-world outcomes of treprostinil treatment in very-low-birth-weight infants with pulmonary hypertension : a nationwide cohort study Jieun Jeong, Haemin Kang, Ho Jung Choi, Sohee Oh, Jin A Lee p. 56-65, [1]
Language outcomes in moderate-to-late preterm infants at 2 years of corrected age Sung Hee Lee, Ju Hyun Jin, Shin Won Yoon p. 66-73
Neurodevelopmental outcomes at 1 year of age after extubation failure in very preterm infants : a single-center cohort study Ju Hee An, Kyung Hee Park, Mun Hui Jeong, Seong Hee Jeong, NaRae Lee, Shin Yun Byun, Su Jeong Park p. 74-81
Short- and long-term morbidities in preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation Jung In Kang, Sangjun Park, So-Yeon Shim, Joo Yun Yang, Young Min Youn, Ye Jin Han, Do Kyung Lee, Hyun Kyung Bae, Soeun Park, Jin A Sohn p. 82-92, [1]
Posthemorrhagic ventricular dilatation after grade Ⅱ–Ⅳ intraventricular hemorrhage in neonates : a single-center cohort study Hye Jin Park, Sang-Yoon Lee, Hyeong-Taek Woo, Ji Sook Kim p. 93-104, [1-3]
Infants with sacral dimples : clinical outcomes and usefulness of ultrasonography Sung Hee Lee, Ju Hyun Jin, Shin Won Yoon p. 105-111
Molybdenum cofactor deficiency type B mimicking hypoxic-ischemic encephalopathy in a neonate : the first genetically confirmed case in Korea Soowan Shin, Baek Sup Shin, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim, Jung Min Ko, Jong-Hee Chae, Soo Yeon Kim, Seung Bok Lee p. 112-116

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