본문 바로가기 주메뉴 바로가기
22대 대한민국 국회 국회정보길라잡이 국회의원검색
회원가입 로그인
HOME

정보검색

소장정보 검색

국회도서관 홈으로 정보검색 소장정보 검색

결과 내 검색

동의어 포함

고급검색

인명/단체명

저자정보 상세정보
인명/단체명을 입력하세요.

키워드

  • 대표어

  • 외국어

-

초록보기

Azithromycin-resistant Neisseria gonorrhoeae poses a threat to the efficacy of gonorrhea treatment. We report the whole-genome characterization of two azithromycin-resistant N. gonorrhoeae ST1600 isolates collected in Busan, South Korea, in 2018 and 2019. Both isolates showed moderate azithromycin resistance (minimum inhibitory concentration 32 µg/mL) mediated by the 23S rRNA C2611T mutation in all four alleles and the -35A deletion in the mtrR promoter, while harboring distinct non-mosaic penA alleles without reduced susceptibility to extended-spectrum cephalosporins. Multilocus sequence typing classified both isolates as ST1600, which is related to ST7363. N. gonorrhoeae multi-antigen sequence typing assigned the 2018 isolate to ST16190, whereas the 2019 isolate represented a novel NG-MAST type closely related to ST16190 (differing by a single SNP in porB). Taken together, these data suggest a limited local transmission cluster with short-term persistence and microevolution, rather than widespread sustained clonal dissemination. Continued phenotypic and genomic surveillance is needed to monitor azithromycin resistance in N. gonorrhoeae and inform national treatment strategies.

Azithromycin-resistant Neisseria gonorrhoeae poses a threat to the efficacy of gonorrhea treatment. We report the whole-genome characterization of two azithromycin-resistant N. gonorrhoeae ST1600 isolates collected in Busan, South Korea, in 2018 and 2019. Both isolates showed moderate azithromycin resistance (minimum inhibitory concentration 32 µg/mL) mediated by the 23S rRNA C2611T mutation in all four alleles and the -35A deletion in the mtrR promoter, while harboring distinct non-mosaic penA alleles without reduced susceptibility to extended-spectrum cephalosporins. Multilocus sequence typing classified both isolates as ST1600, which is related to ST7363. N. gonorrhoeae multi-antigen sequence typing assigned the 2018 isolate to ST16190, whereas the 2019 isolate represented a novel NG-MAST type closely related to ST16190 (differing by a single SNP in porB). Taken together, these data suggest a limited local transmission cluster with short-term persistence and microevolution, rather than widespread sustained clonal dissemination. Continued phenotypic and genomic surveillance is needed to monitor azithromycin resistance in N. gonorrhoeae and inform national treatment strategies.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
Performance of an AI-based automated feces analyzer compared with the formalin-ether concentration technique for intestinal parasite detection : a diagnostic accuracy study Hui-Jin Yu, Tae Yeul Kim, Eun Jeong Won, Hee Jae Huh p. 1-9
Evaluating the adequacy of intervals for repeat antimicrobial susceptibility testing Yu Jin Park, Xinyi Lu, Sunghyuk Kim, Shinyoung Yoon, Daewon Kim, Ki Ho Hong, Hyukmin Lee, Dongeun Yong p. 1-11
Whole-genome characterization of two azithromycin-resistant Neisseria gonorrhoeae ST1600 isolates from Busan, South Korea Changseung Liu, Young Hee Seo, Kyoung Ho Roh, Hyukmin Lee, Kyungwon Lee p. 1-5
Laser scattering signal amplification and deep learning for detection of Candida culture positivity in women with vaginal symptoms : a preliminary analytical and pilot clinical evaluation Jeong Su Park, Jehada-Inn Alihuddin, Kidong Kim, Kyoungman Cho, Jung-A Shin, Mulbora Jee p. 1-14

추천서가 (다양한 추천 자료를 만나보세요)

권호기사보기

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 기사목차

권호

기사명 원문보기 기사목차
닫기