Figure1-1. Analysis of Signal molecules on SNU16 stomach cancer cells after ionizing radiation=75,96,1

Figure1-2. MMC and TRAIL-induced apoptosis in adenocarcinoma cells=76,97,1

Figure1-3. MMC and TRAIL-induced DNA fragmentation in adenocarcinoma cell=77,98,1

Figure1-4. Caspase activation by MMC in adenocarcinoma cells=78,99,1

Figure1-5. TRAIL induced apoptosis=79,100,1

Figure1-6. Inhibition of caspase-induced apoptosis by caspase inhibitor=80,101,1

Figure1-7. RT-PCR analysis of Fas & FasL=81,102,1

Figure1-8. Effect of AEBSF on apoptosis-induced by TRAIL=82,103,1

Figure1-9. NO production by ionizing radiation and arsenic trioxide and apoptosis induced by ionizing radiation in HeLa cells=83,104,1

Figure1-10. Sensitizing effects og SNP and arsenic trioxide in IR-induced apoptosis in HeLa cells=84,105,1

Figure1-11. RT-PCR of Fas in arsenic trioxide or SNP=85,106,1

Figure1-12. Fas expression in ionizing radiation-treated HeLa cells=85,106,1

Figure1-13. Fas ewpression in SNP or arsenic trioxide-treated HeLa cells=86,107,1

Figure1-14. Caspase-8 activation in SNP or arsenic trioxide in HeLa cells=87,108,1

Figure1-15. IR and NO donor SNAP sensitize cervical carcinoma cells to Fas-Mediated apoptosis cell death=88,109,1

Figure1-16. iNOS expression in IR or SNP-treated HeLa cells=89,110,1

Figure1-17. Effects of As₂O₃on the growth of HeLa cells=90,111,1

Figure1-18. Dual-parameter flow-cytometric analysis and DNA fragmentation assay of apoptosis HeLa cells after As₂O₃treatment=90,111,1

Figure1-19. Change of mitochondria membrane potential in HeLa cells treated with As₂O₃=91,112,1

Figure1-20. Caspase-3 activation in As₂O₃-induced apoptosis=92,113,1

Figure1-21. Effect og overexpression of Bcl-2 in HeLa cells on cell survival,mitochondrial membrane potential and apoptosis=93,114,1

Figure1-22. H₂O₂production and involvement in As₂O₃-induced apoptosis=94,115,1

Figure1-23. Colony forming assay of glioblastoma cells after radiation=95,116,1

Figure1-24. Analysis of Signal molecules in D54 brain tumor cells after ionizing radiation=96,117,1

Figure1-25. Analysis of Signal molecules in U87MG glioblastima cancer cells after ionizing radiation=96,117,1

Figure1-26. Analysis of Signal molecules after ionizing radiation in D54MG human glioclastoma cells=97,118,1

Figure1-27. Northern blot analysis of ASK1 in tissue of gastric cancer=98,119,1

Figure1-28. Comparison of sensitivity to the various cell death signal in stomach cancer cells=99,120,1

Figure1-29. Comparison of Fas expression and MAPK activity in stomach cancer cells=100,121,1

Figure1-30. Function os SAPK on apoptosis in mutant MKK4 transfected cells=101,122,1

Figure1-31. Effect of SAPK on the apoptosis in mutant MKK4 transfected cells=102,123,1

Figure1-32. Comparision of SAPK between SNU-16 and SNU-620 stomach cancer cells=103,124,1

Figure1-33. Comparision of Bcl family between SNU-16 and SNU-620 cells=104,125,1

Figure1-34. Effect of Bcl-w on SAPK in stomach cancer cells=105,126,1

Figure1-35. Effect of Bcl-w on apoptosis in stomach cancer cells=106,127,1

Figure1-36. Expression of Bcl-w on stomach cancer tissuse=107,128,1

Figure1-37. Induction of spondle checkpoint regulator p55cdc by irradiation=108,129,1

Figure1-38. Cell cycle analysis in p55CDC mutant transfected HeLa cells=109,130,1

Figure1-39. Comparison of p16 ecpression and tumor-free survival in transgenic mice=110,131,1

Figure1-40. Southern syrategy for the generation og INK4 knock-out mice=111,132,1

Figure1-41. PCR-SSCP of CMT gene in human hepatoma cell lines and tissue=112,133,1

Figure1-42. Gene-typing of p53 gene by PCR=113,134,1

Figure1-43. Immunophenotypic characteristics in Hank-1 cells by immunohistochemistry=114,135,1

Figure1-44. Survivality of Hank-1 cells and Jurkat cells according to dose of irradiation=115,136,1

Figure1-45. Cell death curve of Hank-1 cells accorsing tp time sequence and radiation dosage=116,137,1

Figure1-46. Apoptosis induced by irradiation in Hank-1 cells using TUNEL method=117,138,1

Figure1-47. Apoptosis induced by irradiation in Hank-1 cells using Hoechst staining=118,139,1

Figure1-48. RNA expression of bcl-2 family members by RNase prltection assay in various cell lines without irradiation=119,140,1

Figure1-49. Protein expression of bcl-2 family members after irradiation by western blotting=120,141,1

Figure1-50. The changes of RNA level of caspase-8 and FAS after irradiation in Hank-1 cell line by RNase protection assay=121,142,1

Figure1-51. The changes of RNA level of caspase after irradiation in Hank-1 cell line by RNase protefction assay=122,143,1

Figure1-52. Activation of caspase after irradiation in Hank-1 cells and Jurkat cells=123,144,1

Figure1-53. Activation of JNK after irradiation in Hank-1 cells=124,145,1

Figure1-54. Activation of p38 after irradiation in Hank-1 cells=125,146,1

Figure1-55. Activation of Erk after irradiation in Hank-1 cell=126,147,1

Figure2-1. Effect of TGFb1 on the morphology of SiHa cells in submered culture=127,148,1

Figure2-2. Biochemical TGFb1 responses on expressions of actin,ECM components,and integrins,activation of FAK,and expession of E-cadherin=128,149,1

Figure2-3. Role of integrin av in TGFb1-induced actin reorganization=129,150,1

Figure2-4. Actin reorganization and FN matrix assembly in TGFb1-treated SiHa cells were two separate events=130,151,1

Figure2-5. Irreveersinle effect of TGFb1 on actin reorganization and FN matrix assembly in SiHa cells=131,152,1

Figure2-6. Exploration of possible signaling molecules invollved in TGFb1- induced actin reorganization=132,153,1

Figure2-7. Effect of TGFb1 on invasive transition and MMPs activity in SiHa cells=133,154,1

Figure2-8. Effect of calcipotriol on cell growth,proliferation,apoptosis,and differention of SCC13 cells=134,155,1

Figure2-9. Effect fo calcipotriol on EGFR dephosphopeylation in SCC13 cell line=135,156,1

Figure2-10. Effect of extrcellular calcium concentration on the dephosphorylation of EGFR induced by calcipotriol=136,157,1

Figure2-11. Calcium dependency of calcipotriol-mediayed ingibition of cell proliferation=137,158,1

Figure2-12. TGFb1-induced phosphorylation of EGFR and Erk1／2=138,159,1

Figure2-13. TGFb1-induced Erk phosphorylation vir EGFR signaling pathway=139,160,1

Figure2-14. TGFb1-induced phosphorylation of EGFR and Erk involves reactive oxygen species=140,161,1

Figure2-15. TGFb1-induced phosphorylation of EGFR and Erk involves Ca²+ -dependent pathway=141,162,1

Figure2-16. Effect of the crosstalk between TGFb1 and EGFR signaling pathway on TGFb1-induced expression of c-jun and c-Fos=142,163,1

Figure2-17. Effect of the crosstalk between TGFb1 and EGFR signaling pathway on TGFb1-induced expression of fibronectin=143,164,1

Figure2-18. proposed signaling pathway of TGFb1 in SCC13 cells=144,165,1

Figure2-19. PMA icduced secretion fo MMP-9 and activation of MMP-2 were inhibited by p38 MAPK inhibitor SB203580=145,166,1

Figure2-20. Effect of SB203580 ON MT1-MMP and TIMP-2 localization on the cell surface,induced by PMA=146,167,1

Figure2-21. Effect of PMA and SB203580 on the MMP-9 secretion and MMP-2 activation=147,168,1

Figure2-22. Effect of HA on the secretion of MMP-9 in various glioma dell lines with mutant-type PTEN or wild-type PTEN=148,169,1

Figure2-23. Effect of PTEN on MMPs and TIMPs secretion,and in vitro induced by HA in U87MG cells=149,170,1

Figure2-24.／Figure2-23 Effect of various kinase inhibitors antisense FAK oligonucleotides on the secretion of MMP-9 by HA in U87MG cells=150,171,1

Figure2-25.／Figure2-24 Role of protein phosphatase activity of PTEN on the secretion of MMP-9 and in vitro invasion by HA=151,172,1

Figure2-26.／Figure2-25 Effect of PTEN on the HA-induced MMP-9 expression=152,173,1

Figure3-1. Differential Display-PCR of mRNA in anticancer drug-sensitive and resistant tumor tissue=153,174,1

Figure3-2. Reamplification of a LET4 gene fragment by PCR=154,175,1

Figure3-3. Sequensing analysis of the LET4 gene fragment=155,176,1

Figure3-4. Flow diagram showing cDNA library construction and LET4 screening=156,177,1

Figure3-5. Screening of LET4=157,178,1

Figure3-6. Don hybridization of LET4=158,179,1

Figure3-7. Northern blot analysis of LET4 in various cancer cell lines=159,180,1

Figure3-8. Constrystion of pcDNA3-LET4 Sense／Antisense=160,181,1

Figure3-9. CDDP sensitivity assay of pcDNA3-LET4 Sense／Antisense=161,182,1

Figure3-10. ADR sensitivity assay of pcDNA3-LET4 Sense／Antisense=162,183,1

Figure3-11. Stable transfection of COX-2 gene=163,184,1

Figure3-12. Colony forming assay of lung cancer cell lines,H460 and A549 after ionizing radiation=164,185,1

Figure3-13. MTT assay of lung cancer cell lines after treatment of COX-2 inhibitor Nimensulide=165,186,1

Figure3-14. MTT assay of lung cancer cell lines after treatment of COX-2 inhibitor Celecoxib=166,187,1

Figure3-15. Survival fraction of lung cancer cell lines,H460 and A549 after ionizing radiation and Nimensulide treatment=167,188,1

Figure3-16. Survival fraction of lung cancer cell lines,H460 and A549 after ionizing radiation and Celecoxib treatment=168,189,1

Figure3-17. Cox-2 activity assay on H460 lung cancer cells after ionizing radiation and anti-tumor agents treatment=169,190,1

Figure3-18. Cox-2 activity assay on A549 lung cancer cells after ionizing radiation and anti-tumor agents treatment=170,191,1

Figure3-19. Cox-2 activity assay in radioresistant H460 lung cancer cells after ionizing radiation and anti-tumor agents=171,192,1

Figure3-20. Catalase Activity of RRC and U251 after 5Gy radiation=171,192,1

Figure3-21. Glutathione reductase Activity of RRC AND u251 AFTER 5Gy radiation=172,193,1

Figure3-22. Glutathione peroxidase Activity of RRC and U251 after 5Gy radiation=172,193,1