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Paneth Cell α-Defensin Synthesis and Function 1

A.J.Ouellette

Immunomodulatory Properties of Defensins and Cathelicidins 27

D.M.E.Bowdish,D.J.Davidson, and R.E.W.Hancock

Host Antimicrobial Defence Peptides in Human Disease 67

B.Agerberth and G.H.Gu∂mundsson

Antimicrobial Peptides:

AnEssential Component of the Skin Defensive Barrier 91

M.H.Braff and R.L.Gallo

Antimicrobial Peptides Versus Invasive Infections 111

M.R.Yeaman and A.S.Bayer

Antimicrobial Peptides in the Airway 153

D.M.Laube,S.Yim, L.K.Ryan, K.O.Kisich, and G. Diamond

Hepcidin-A Peptide Hormone at the Interface of Innate Immunity and Iron Metabolism 183

T.Ganz

Innate Host Defense of Human Vaginal and Cervical Mucosae 199

A.M.Cole

Molecular mechanisms of Bacterial Resistance to Antimicrobial Peptides 231

D.Kraus and A. Peschel

Bacterial Evasion of Antimicrobial Peptides by biofilm Formation 251

M. Otto

Subject Index 259

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Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.



Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far out number those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.



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