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Title page 1

Contents 4

Acknowledgements 8

Abbreviations 9

Glossary 10

Executive summary 14

Scope and purpose, objectives, and target audience 14

Guideline development methodology 15

Recommendations, justifications and remarks 16

Dietary interventions 16

Physical activity, sedentary behaviour, and sleep 18

Behaviour changing interventions 19

Digital health interventions 20

Pharmacotherapy 21

Bariatric surgery and weight-loss and weight-management devices 22

Multimodal interventions 23

Research gaps 24

Plans for updating 24

References 25

Background 26

Scope and purpose, objectives, and target audience 31

Scope and purpose 31

Objectives 31

Target audience 32

Guideline development 33

Interventions included in this guideline for evidence search and recommendations 33

Principles and existing documents related to this new guideline 34

Technical and Guideline Development Group meetings convened for developing this guideline 36

List of guideline questions and outcomes 37

Questions 37

Background questions 37

Key population, intervention, comparison, outcome (PICO) questions 37

Additional questions 39

Outcomes 39

Critical (primary) outcomes 39

Important (secondary) outcomes 40

Recommendations 41

Dietary interventions 41

Summary of evidence 41

Recommendation 43

Justification 44

Remarks 44

Research gaps 45

Summary of judgements 45

Physical activity, sedentary behaviour, and sleep 46

Summary of evidence 46

Recommendation 47

Justification 47

Remarks 48

Research gaps 48

Summary of judgements 48

Behaviour changing interventions 49

Summary of evidence 49

Recommendation 51

Justification 51

Remarks 51

Research gaps 52

Summary of judgements 52

Digital health interventions 53

Summary of evidence 53

Recommendation 54

Justification 54

Remarks 54

Research gaps 54

Summary of judgements 55

Pharmacotherapy 55

Summary of evidence 55

Recommendation 56

Justification 57

Remarks 57

Research gaps 57

Summary of judgements 57

Bariatric surgery and weight-loss and weight-management devices 58

Summary of evidence 58

Recommendation 58

Justification 58

Remarks 58

Research gaps 59

Summary of judgements 59

Multimodal interventions 59

Summary of evidence 59

Recommendation 61

Justification 61

Remarks 61

Research gaps 62

Summary of judgements 62

Guideline development methodology 63

Participants in the guideline development process 63

Declarations of interest and management of conflicts of interest 64

Formulation of questions and outcome selection 66

Evidence retrieval, synthesis and assessment 67

Developing recommendations 67

External review 68

Final guideline manuscript and WHO Guidelines Review Committee approval 68

Dissemination, implementation, monitoring, evaluation, and ethical considerations 69

Dissemination 69

Implementation 69

Monitoring and evaluating guideline implementation 70

Ethical considerations 70

Updating recommendations 71

References 72

Annex 1. Background questions 85

Annex 2. GRADE summary of findings tables 91

Summary of findings: Physical activity, sedentary behaviour, and sleep 98

Summary of findings: Behaviour changing interventions 106

Summary of findings: Digital health interventions 113

Summary of findings: Pharmacotherapy 115

Summary of findings: Multimodal interventions 117

Annex 3. Summary of Guideline Development Group considerations to determine the strength of the recommendations 123

Evidence-to-decision considerations for dietary interventions 123

Evidence-to-decision considerations for physical activity, sedentary behaviour, and sleep 124

Evidence-to-decision considerations for behaviour changing interventions 125

Evidence-to-decision considerations for digital health interventions 126

Evidence-to-decision considerations for pharmacotherapy 127

Evidence-to-decision considerations for bariatric surgery and weight-loss and weight-management devices 129

Evidence-to-decision considerations for multimodal interventions 129

Annex 4. WHO Obesity Steering Committee 131

Annex 5. WHO Guideline Development Group 133

Annex 6. Systematic review teams 136

Annex 7. Observers 140

Annex 8. WHO Secretariat 141

Annex 9. External reviewers 143

Tables 37

Table 1. Key questions for guideline development included in this guideline 37

Table 2. Conflicts of interest declarations, and how potential conflicts were addressed during the guideline development process 64

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