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Title page 1

Contents 4

Acknowledgements 8

Abbreviations 9

Glossary 10

Executive summary 14

Scope and purpose, objectives, and target audience 14

Guideline development methodology 15

Recommendations, justifications and remarks 16

Dietary interventions 16

Physical activity, sedentary behaviour, and sleep 18

Behaviour changing interventions 19

Digital health interventions 20

Pharmacotherapy 21

Bariatric surgery and weight-loss and weight-management devices 23

Weight-loss and weight-management devices 23

Multimodal interventions 24

Research gaps 25

Plans for updating 26

References 26

Background 28

Scope and purpose, objectives, and target audience 32

Scope and purpose 32

Objectives 32

Target audience 33

Guideline development 34

Interventions included in this guideline for evidence search and recommendations 34

Principles and existing documents related to this new guideline 35

Technical and Guideline Development Group meetings convened for developing this guideline 37

List of guideline questions and outcomes 38

Questions 38

Background questions 38

Key population, intervention, comparison, outcome (PICO) questions 38

Additional questions 40

Outcomes 40

Critical (primary) outcomes 40

Important (secondary) outcomes 41

Recommendations 42

Dietary interventions 42

Summary of evidence 42

Recommendation 46

Justification 46

Remarks 46

Research gaps 47

Summary of judgements 48

Physical activity, sedentary behaviour, and sleep 48

Summary of evidence 48

Recommendation 49

Justification 49

Remarks 50

Research gaps 50

Summary of judgements 51

Behaviour changing interventions 51

Summary of evidence 51

Recommendation 53

Justification 53

Remarks 54

Research gaps 54

Summary of judgements 55

Digital health interventions 55

Summary of evidence 55

Recommendation 56

Justification 56

Remarks 57

Research gaps 57

Summary of judgements 57

Pharmacotherapy 58

Summary of evidence 58

Recommendation 60

Justification 60

Remarks 60

Research gaps 61

Summary of judgements 61

Bariatric surgery and weight-loss and weight-management devices 62

Summary of evidence 62

Recommendation 1 63

Recommendation 2 64

Justification for recommendations on bariatric surgery 64

Remarks 64

Research gaps 65

Summary of judgements 65

Multimodal interventions 65

Summary of evidence 65

Recommendation 67

Justification 67

Remarks 67

Research gaps 68

Summary of judgements 68

Guideline development methodology 70

Participants in the guideline development process 70

Declarations of interest and management of conflicts of interest 71

Formulation of questions and selection of outcomes 72

Evidence retrieval, synthesis and assessment 72

Developing recommendations 73

External review 73

Final guideline manuscript and WHO Guidelines Review Committee approval 73

Dissemination, implementation, monitoring, evaluation, and ethical considerations 74

Dissemination 74

Implementation 74

Monitoring and evaluating guideline implementation 75

Ethical considerations 75

Updating recommendations 76

References 77

Annex 1. Background questions 90

Annex 2. GRADE summary of findings tables 95

Summary of findings: Dietary interventions 95

Summary of findings: Physical activity, sedentary behaviour, and sleep 118

Summary of findings: Behaviour changing interventions 123

Summary of findings: Digital health interventions 130

Summary of findings: Pharmacotherapy 131

Summary of findings: Bariatric surgery and weight-loss and weight-management devices 134

Summary of findings: Multimodal interventions 136

Annex 3. Summary of Guideline Development Group considerations to determine the strength of the recommendations 141

Evidence-to-decision considerations for dietary interventions 141

Evidence-to-decision considerations for physical activity, sedentary behaviour, and sleep 142

Evidence-to-decision considerations for behaviour changing interventions 144

Evidence-to-decision considerations for digital health interventions 145

Evidence-to-decision considerations for pharmacotherapy 146

Evidence-to-decision considerations for bariatric surgery and weight-loss and weight-management devices 147

Evidence-to-decision considerations for multimodal interventions 148

Annex 4. WHO Obesity Steering Committee 149

Annex 5. WHO Guideline Development Group 151

Annex 6. Systematic review teams 153

Annex 7. Observers 157

Annex 8. WHO Secretariat 158

Annex 9. External reviewers 160

Tables 38

Table 1. Key questions for guideline development included in this guideline 38

Table 2. Conflicts of interest declarations, and how potential conflicts were addressed during the guideline development process 71

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