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Contents

Executive Summary 3

Introduction 11

Investing in the Building Blocks of Innovation 21

Making World-Leading Investments in Fundamental Research 22

Boosting Access to High-Quality STEM Education 25

Clearing a Path for Immigrants to Propel the Innovation Economy 30

Building a Leading 21st Century Physical Infrastructure 33

Building a Next-Generation Digital Infrastructure 34

Fueling the Engine of Private-Sector Innovation 40

Strengthening the Research and Experimentation Tax Credit 41

Supporting Innovative Entrepreneurs 43

From Lab to Market: Commercializing Federally-Funded Research 48

Ensuring the Right Framework Conditions for Innovation 52

Empowering Innovators with Open Federal Data 57

Supporting the Development of Regional Innovation Ecosystems 60

Helping American Businesses Compete Abroad 63

Empowering a Nation of Innovators 66

Harnessing the Creativity of the American People through Incentive Prizes 68

Tapping the Talents of Innovators through Making, Crowdsourcing, and Citizen Science 70

Creating Quality Jobs and Lasting Economic Growth 75

Sharpening America's Edge in Advanced Manufacturing 77

Investing in the Industries of the Future 80

Building an Inclusive Innovation Economy 83

Catalyzing Breakthroughs for National Priorities 85

Tackling Grand Challenges 86

Targeting Disease with Precision Medicine 88

Accelerating the Development of New Neurotechnologies through the BRAIN Initiative 90

Driving Breakthrough Innovations in Health Care 92

Dramatically Reducing Fatalities with Advanced Vehicles 93

Building Smart Cities 95

Promoting Clean Energy Technologies and Advancing Energy Efficiency 97

Delivering a Revolution in Educational Technology 100

Developing Breakthrough Space Capabilities 102

Pursuing New Frontiers in Computing 104

Harnessing Innovation to End Extreme Global Poverty by 2030 106

Delivering Innovative Government with and for the People 108

Adopting an Innovation Toolkit for Public-Sector Problem-Solving 110

Fostering a Culture of Innovation through Innovation Labs at Federal Agencies 112

Providing Better Government for the American People through More Effective Digital Service Delivery 114

Building and Using Evidence to Drive Social Innovation 116

New Horizons for 2015 and Beyond 118

A 21st Century Call to Serve 118

Harnessing Financial Innovation for National Priorities 119

Increasing the Role of "Demand Pull" in America's Innovation Strategy 120