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22대 대한민국 국회 국회정보길라잡이 국회의원검색
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Abbreviations

국문요약

Abstract

Conrents

Introduction 17

Materials and Methods 21

1. Animals 21

2. Preparation of Liver Proteins from HBx mice 21

3. Determination of nitrite/nitrate concentration 22

4. RNA preparation and Reverse-transcription PCR (RT-PCR) 23

5. Western blot analysis 24

6. Analysis of ranitidine metabolites by HPLC 25

7. Thiobenzamide S-oxidation Assay 27

8. Immunohistochemical Staining 28

9. Data analysis 30

Results 31

1. Plasma NOx concentration 31

2. Expression of iNOS protein 31

3. Expression of FMO mRNAs 32

4. Expression of FMO proteins 32

5. Hepatic microsomal FMO activity by ranitidine (RA) N-oxidation assay 32

6. Hepatic microsomal FMO activity by thiobenzamide (TB) S-oxidation assay 33

7. In vitro effect of S-nitrosylation by DTT on hepatic FMO activiry 34

8. Nitration of microsomal proteins 35

9. Histology findings of iNOS protein in the HBx mice liver tissues 35

10. Differential expression of FMOs and iNOS in cancerous and non-cancerous liver tissues 36

Discussion 37

References 43

List of Figures

Fig. 1. Plasma NOx (nitrite plus nitrate) concentrations determined in male HBx mouse 53

Fig. 2. Protein expression and the levels of iNOS in liver tissues of male HBx mice 54

Fig. 3. mRNAs expression and the levels of three FMO isoforms in liver tissues of male HBx mouse 55

Fig. 4. Protein expression and the levels of FMOs in liver tissues of male HBx mice 56

Fig. 5. Microsomal FMO activities determined in liver tissues of male HBx mice 57

Fig. 6. Microsomal FMO activities determined in liver tissues of male HBx mice 58

Fig. 8. Nitration levels of total microsomal proteins in male HBx mouse livers 60

Fig. 9. Immunohistochemical distribution of iNOS in male HBx mouse liver tissues 61

Fig. 10. Differential expression of FMOs and iNOS in cancerous and non-cancerous liver tissues 62

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